Endocrine disrupting chemical Bisphenol A and its potential effects on female health

Kawa, Iram Ashaq; Akbar, Muhammad; Fatima, Qudsia; Mir, Shabir Ahmad; Jeelani, Humira; Manzoor, Saika; Rashid, Fouzia

doi:10.1016/j.dsx.2021.03.031

Cited by 71 publications

(30 citation statements)

References 98 publications

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“…Figure 3: Schematic representation of emerging pollutant exposures, mode of action, and their health effects (based on [25,68,69]). Abbreviations: ERs, estrogen receptors; CYP, cytochrome P450 genes; and DNA, deoxyribonucleic acid.…”

Section: Treatment Processes For Ep Removalmentioning

confidence: 99%

Emerging Pollutants in Moroccan Wastewater: Occurrence, Impact, and Removal Technologies

Jari

Roche

Necibi

et al. 2022

Journal of Chemistry

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The rapid growth of anthropogenic activities in recent decades has resulted in the appearance of numerous new chemical compounds in the environment, known as “emerging pollutants” (EPs) or “contaminants of emerging concern” (CECs). Although partially or not yet regulated or monitored, there is growing research interest in these EPs among the scientific community because of their bioaccumulation, persistence, and adverse effects. Among these, endocrine disruptors, pesticides, and pharmaceuticals can have harmful impacts on human health and the ecosystem. Conventional wastewater treatment technologies are not effective in removing these contaminants, allowing them to be released into the receiving environment. In order to improve the understanding of emerging pollutants, this review discusses the source, occurrence, and impacts of bisphenol A, atrazine, amoxicillin, and paracetamol as model molecules of emerging environmental pollutants, an issue that remains underrepresented in Morocco. Then, treatment methods for EPs are reviewed, including adsorption, advanced oxidation processes, biodegradation, and hybrid treatment. It is proposed that adsorption and photocatalysis can be used as simple, effective, and environmentally friendly technologies for their removal. Thus, we summarize some of the adsorbent and photocatalyst materials applied in recent work to control these pollutants. Towards the end of this paper, the development of inexpensive and locally available (Morocco) materials to remove these compounds from wastewater is considered.

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Section: Treatment Processes For Ep Removalmentioning

confidence: 99%

Emerging Pollutants in Moroccan Wastewater: Occurrence, Impact, and Removal Technologies

Jari

Roche

Necibi

et al. 2022

Journal of Chemistry

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“…Bisphenol A (BPA), a plasticizer, was reported as an endocrine disruptor that impairs both male and female reproductive function ( 1 – 3 ), and has been banned in the food industry in several countries (Canada, Belgium and France). BPA was then replaced by structural analogues, including bisphenol S (BPS).…”

Section: Introductionmentioning

confidence: 99%

Bisphenol S Alters the Steroidome in the Preovulatory Follicle, Oviduct Fluid and Plasma in Ewes With Contrasted Metabolic Status

et al. 2022

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Bisphenol A (BPA), a plasticizer and endocrine disruptor, has been substituted by bisphenol S (BPS), a structural analogue that had already shown adverse effects on granulosa cell steroidogenesis. The objective of this study was to assess the effect of chronic exposure to BPS, a possible endocrine disruptor, on steroid hormones in the ovary, oviduct and plasma using the ewe as a model. Given the interaction between steroidogenesis and the metabolic status, the BPS effect was tested according to two diet groups. Eighty adult ewes were allotted to restricted (R) and well-fed (WF) groups, that were further subdivided into two subgroups. Ewes were exposed to 50 µg BPS/kg/day in their diet (R50 and WF50 groups) or were unexposed controls (R0 and WF0 groups). After at least 3 months of BPS exposure, preovulatory follicular fluid, oviduct fluid and plasma were collected and steroid hormones were analyzed by gas chromatography coupled with tandem mass spectrometry (GC-MS/MS). A deleterious effect of restricted diet on the volume of oviduct fluid and numbers of pre-ovulatory follicles was observed. Exposure to BPS impaired estradiol concentrations in both follicular and oviduct fluids of well-fed ewes and progesterone, estradiol and estrone concentrations in plasma of restricted ewes. In addition, a significant interaction between metabolic status and BPS exposure was observed for seven steroids, including estradiol. In conclusion, BPS acts in ewes as an endocrine disruptor with differential actions according to metabolic status.

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“…Some EDCs have the capacity to alter steroid hormone synthesis by inhibiting enzymes of the steroidogenic pathway, binding of hormones receptors, and by altering hormone secretion ( Nam et al, 2003 ; Bloom et al, 2016 ; Hannon and Flaws, 2015). Abnormalities in ovarian steroid hormone production, synthesis, and systemic circulation is implicated in menstrual cycle irregularities and anovulation incidence ( Kawa et al, 2021 ).…”

Section: Resultsmentioning

confidence: 99%

Bovine In Vitro Oocyte Maturation and Embryo Production Used as a Model for Testing Endocrine Disrupting Chemicals Eliciting Female Reproductive Toxicity With Diethylstilbestrol as a Showcase Compound

et al. 2022

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Endocrine disrupting chemicals (EDCs) can interfere with normal hormonal action and regulation. Exposure of women to EDCs has been associated with adverse reproductive health outcomes. The assays currently used to identify EDCs that elicit female reproductive toxicity lack screening tests that address effects on the maturation of oocytes, a process that enables them to be fertilized and develop into embryos. Here, a screening method employing the bovine model of in vitro oocyte maturation and embryo production is described. Endpoints explored address important events in oocyte maturation and developmental competence acquisition. To test the method, the effects of the known human EDC diethylstilbestrol (DES; an estrogen receptor agonist) were evaluated in a range of concentrations (10–9 M, 10–7 M, 10–5 M). Bovine oocytes were exposed to DES during in vitro maturation (IVM) or embryos were exposed during in vitro embryo culture (IVC). The endpoints evaluated included nuclear maturation, mitochondrial redistribution, cumulus cell expansion, apoptosis, and steroidogenesis. DES-exposed oocytes were fertilized to record embryo cleavage and blastocyst rates to uncover effects on developmental competence. Similarly, the development of embryos exposed to DES during IVC was monitored to assess the impact on early embryo development. Exposure to 10–9 M or 10–7 M DES did not affect the endpoints addressing oocyte maturation or embryo development. However, there were considerable detrimental effects observed in oocytes exposed to 10–5 M DES. Specifically, compared to vehicle-treated oocytes, there was a statistically significant reduction in nuclear maturation (3% vs 84%), cumulus expansion (2.8-fold vs 3.6-fold) and blastocyst rate (3% vs 32%). Additionally, progesterone and pregnenolone concentrations measured in IVM culture media were increased. The screening method described here shows that bovine oocytes were sensitive to the action of this particular chemical (i.e., DES), albeit at high concentrations. In principle, this method provides a valuable tool to assess the oocyte maturation process and early embryo development that can be used for reproductive toxicity screening and possibly EDC identification. Further studies should include EDCs with different mechanisms of action and additional endpoints to further demonstrate the applicability of the bovine oocyte model for chemical risk assessment purposes and EDC identification.

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Endocrine disrupting chemical Bisphenol A and its potential effects on female health

Cited by 71 publications

References 98 publications

Emerging Pollutants in Moroccan Wastewater: Occurrence, Impact, and Removal Technologies

Emerging Pollutants in Moroccan Wastewater: Occurrence, Impact, and Removal Technologies

Bisphenol S Alters the Steroidome in the Preovulatory Follicle, Oviduct Fluid and Plasma in Ewes With Contrasted Metabolic Status

Bovine In Vitro Oocyte Maturation and Embryo Production Used as a Model for Testing Endocrine Disrupting Chemicals Eliciting Female Reproductive Toxicity With Diethylstilbestrol as a Showcase Compound

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