Endocrine disrupters and possible contribution to pubertal changes

Fudvoye, Julie; López-Rodríguez, David; Franssen, Delphine

doi:10.1016/j.beem.2019.101300

Cited by 52 publications

(33 citation statements)

References 64 publications

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“…Childhood obesity may explain some but not all of the trend toward earlier breast development in girls, 10 while the distribution of menarcheal age has shifted toward lateness in some populations. 9 Similar divergent effects on initial and final pubertal stages have been observed in boys. 1 This suggests a contribution of environmental factors, perhaps including BPA exposure from food and beverage containers, toys, and office products.…”

mentioning

confidence: 53%

“…Improvements in nutrition likely explain some of the observed decrease in the average age at menarche between 1890 and 1960 in Europe and the United States. 9 However, secular changes in puberty onset are complex. Childhood obesity may explain some but not all of the trend toward earlier breast development in girls, 10 while the distribution of menarcheal age has shifted toward lateness in some populations.…”

mentioning

confidence: 99%

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Bisphenol A and Puberty Onset in Female Mice: Developmental Effects of Low-Dose Exposure

Schmidt¹

2020

Environ Health Perspect

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mentioning

confidence: 53%

mentioning

confidence: 99%

Bisphenol A and Puberty Onset in Female Mice: Developmental Effects of Low-Dose Exposure

Schmidt¹

2020

Environ Health Perspect

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“…The pathologies observed with sufficient numbers of animals include the lean phenotype, kidney disease, testis disease, late puberty, and multiple disease where individuals exhibited two or more different pathologies. The pathologies examined in this study are relevant for humans, particularly prostate disease, which is one of the most prominent diseases in human males [46], and delayed puberty associated with exposure to EDCs is a known pathology in humans [47]. Among aging populations, kidney disease prevalence increases in human populations [48].…”

Section: Plos Onementioning

confidence: 99%

Epigenome-wide association study for atrazine induced transgenerational DNA methylation and histone retention sperm epigenetic biomarkers for disease

et al. 2020

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Atrazine is a common agricultural herbicide previously shown to promote epigenetic transgenerational inheritance of disease to subsequent generations. The current study was designed as an epigenome-wide association study (EWAS) to identify transgenerational sperm disease associated differential DNA methylation regions (DMRs) and differential histone retention regions (DHRs). Gestating female F0 generation rats were transiently exposed to atrazine during the period of embryonic gonadal sex determination, and then subsequent F1, F2, and F3 generations obtained in the absence of any continued exposure. The transgenerational F3 generation males were assessed for disease and sperm collected for epigenetic analysis. Pathology was observed in pubertal onset and for testis disease, prostate disease, kidney disease, lean pathology, and multiple disease. For these pathologies, sufficient numbers of individual males with only a single specific disease were identified. The sperm DNA and chromatin were isolated from adult one-year animals with the specific diseases and analyzed for DMRs with methylated DNA immunoprecipitation (MeDIP) sequencing and DHRs with histone chromatin immunoprecipitation (ChIP) sequencing. Transgenerational F3 generation males with or without disease were compared to identify the disease specific epimutation biomarkers. All pathologies were found to have disease specific DMRs and DHRs which were found to predominantly be distinct for each disease. No common DMRs or DHRs were found among all the pathologies. Epimutation gene associations were identified and found to correlate to previously known disease linked genes. This is one of the first observations of potential sperm disease biomarkers for histone retention sites. Although further studies with expanded animal numbers are required, the current study provides evidence the EWAS analysis is effective for the identification of potential pathology epimutation biomarkers for disease susceptibility.

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“…These trends in the timing of puberty, a period of physical and psychological development, have raised concerns regarding the potential impact of environmental factors, including endocrine disrupting chemicals (EDCs) (Blakemore et al 2010;Buck Louis et al 2008;Lee and Styne 2013;Sisk and Foster 2004). Exposure to EDCs prenatally and at the prepubertal stage are thought to play a role in altered pubertal timing, possibly via their estrogenic or anti-androgenic effects and disruption of normal homeostatic control of the hypothalamic-pituitary-gonadal (HPG) or hypothalamic-pituitary-adrenal (HPA) axis (Bellingham et al 2009;Buck Louis et al 2008;Den Hond and Schoeters 2006;Diamanti-Kandarakis et al 2009;Fudvoye et al 2019; Jacobson-Dickman and Lee 2009;Jansen et al 2018;Massart et al 2006;Parent et al 2016;Pescovitz and Walvoord 2007;Rodriguez et al 2019;Roy et al 2009;Watkins et al 2016;Watkins et al 2017).…”

Section: Introductionmentioning

confidence: 99%

In Utero and Peripubertal Metals Exposure in Relation to Reproductive Hormones and Sexual Maturation and Progression among Boys in Mexico City

Ashrap

Meeker

Sánchez

et al. 2020

Preprint

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Background: Endocrine disrupting chemicals (EDCs) such as metals have been reported to alter circulating reproductive hormone concentrations and pubertal development in animals. However, the relationship has rarely been investigated among humans, with the exception of heavy metals, such as Pb and Cd. Our aim was to investigate measures of in utero and peripubertal metal exposure in relation to reproductive hormone levels and sexual maturation and progression among boys from the Early Life Exposure in Mexico to Environmental Toxicants (ELEMENT) cohorts.Methods: Our analysis included 118 pregnant women and their male children from the ELEMENT study. Essential and non-essential metals were measured in urine collected from the mothers during the third trimester of pregnancy and their male children at 8-14 years. Reproductive hormone levels [serum testosterone, estradiol, dehydroepiandrosterone sulfate (DHEA-S), inhibin B, and sex hormone-binding globulin (SHBG)] were measured in blood samples from the children at 8-14 years. We also assessed Tanner stages for sexual maturation (genital, pubic hair development, and testicular volume), at two time points (8–14, 10-18 years). We used linear regression to independently examine urinary metal levels in relation to each peripubertal reproductive hormones adjusting for child age and BMI. Generalized estimation equations (GEEs) were used to evaluate the association of in utero and peripubertal metal exposures with sexual maturation and progression during follow-up based on Tanner staging and testicular volume.Results: In utero and prepubertal concentrations of some urinary metals were associated with increased levels of peripubertal reproductive hormones, especially non-essential metal(loid)s As and Cd (in utero), and Ba (peripubertal) as well as essential metal Mo (in utero) in association with testosterone. More advanced pubic hair developmental stage and higher testicular volume at the early teen visit was observed for boys with higher non-essential metal concentrations, including in utero Al and peripubertal Ba, and essential metal Zn concentration (peripubertal). These metals were also associated with slower pubertal progression between the two visits.Conclusion: These findings suggest that male reproductive development may be associated with both essential and non-essential metal exposure during in utero and peripubertal windows.

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Endocrine disrupters and possible contribution to pubertal changes

Cited by 52 publications

References 64 publications

Bisphenol A and Puberty Onset in Female Mice: Developmental Effects of Low-Dose Exposure

Bisphenol A and Puberty Onset in Female Mice: Developmental Effects of Low-Dose Exposure

Epigenome-wide association study for atrazine induced transgenerational DNA methylation and histone retention sperm epigenetic biomarkers for disease

In Utero and Peripubertal Metals Exposure in Relation to Reproductive Hormones and Sexual Maturation and Progression among Boys in Mexico City

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