Reduced production of thyroid hormone is the central feature of the clinical state termed hypothyroidism (also called as underactive thyroid, low thyroid or hypothyreosis). Primary hypothyroidism which is due to disease of thyroid itself, accounts for approximately 99% of cases while < 1% is due to TSH deficiency known as central or secondary hypothyroidism. Since the main purpose of thyroid hormone is to run our body's metabolism, it is not surprising that people with hypothyroidism often have symptoms associated with a slow metabolism. Worldwide, too little iodine in the diet is the most common cause of hypothyroidism. Hypothyroidism affects approximately 11% of the population of India. This article deals with a case of hypothyroidism homoeopathically managed with a constitutional remedy Natrium Muriaticum. Kent's method of evaluation of symptoms was adopted in this case as the patient showed mostly mental and physical general symptoms.