Endocrine diseases as causes of secondary hyperlipidemia

Bułdak, Łukasz; Marek, Bogdan; Kajdaniuk, Dariusz; Urbanek, Agata; Janyga, Szymon; Bołdys, Aleksandra; Basiak, Marcin; Maligłówka, Mateusz

doi:10.5603/ep.a2019.0041

Cited by 22 publications

(18 citation statements)

References 68 publications

(73 reference statements)

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“…Based on the results obtained in the current study, endocrine resistance (hsa01522), AGE-RAGE signaling pathway in diabetic complications (hsa04933) and p53 signaling pathway (hsa04115) might be the main signaling pathways of AM in the treatment of acquired hyperlipidemia. Endocrine diseases have been highlighted as a fundamental cause of acquired hyperlipidemia [ 26 ]. It was found that active compounds in AM might mediate pancreatic β-cell metabolism, thereby improving insulin secretion [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Mechanism of Astragalus membranaceus Alleviating Acquired Hyperlipidemia Induced by High-Fat Diet through Regulating Lipid Metabolism

et al. 2022

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Astragalus membranaceus (AM) is a food and medicinal homologous plant. The current research is aimed to investigate the beneficial effects and mechanisms of AM in treating acquired hyperlipidemia. The network pharmacology and bioinformatics analysis results showed 481 AM-related targets and 474 acquired hyperlipidemia-associated targets, and 101 candidate targets were obtained through the intersection, mainly enriched in endocrine resistance, AGE-RAGE in diabetic complications and p53 signaling pathways. Quercetin, kaempferol, calycosin, formononetin and isorhamnetin were determined as the candidate active components of AM in the treatment of acquired hyperlipidemia. Moreover, key targets of AM, namely, AKT serine/threonine kinase 1 (AKT1), vascular endothelial growth factor A (VEGFA), cyclin D1 (CCND1) and estrogen receptor 1 (ESR1), were screened out, which were closely related to adipogenesis, fatty acid metabolism and bile acid metabolism. The subsequent animal experiments showed that AM extract treatment improved the lipid profiles of the high-fat diet (HFD)-fed mice by reducing lipogenesis and increasing lipolysis and lipid β-oxidation, which were associated with the downregulating of AKT1 and CCND1, and the upregulating of VEGFA and ESR1 in liver and adipose tissue. Overall, AM alleviated acquired hyperlipidemia through regulating lipid metabolism, and AKT1, VEGFA, CCND1 and ESR1 might be the key targets.

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Section: Discussionmentioning

confidence: 99%

Mechanism of Astragalus membranaceus Alleviating Acquired Hyperlipidemia Induced by High-Fat Diet through Regulating Lipid Metabolism

et al. 2022

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“…Thyroid function has an important impact on lipid profile. Hypothyroidism is one of the common causes of secondary hyperlipidemias [ 135 ]. Elevated TSH level leads to increased expression of PCSK9 [ 136 ].…”

Section: Pcsk9 and The Endocrine Systemmentioning

confidence: 99%

Insight into the Evolving Role of PCSK9

et al. 2022

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Proprotein convertase subtilisin/kexin type 9 (PCSK9) is the last discovered member of the family of proprotein convertases (PCs), mainly synthetized in hepatic cells. This serine protease plays a pivotal role in the reduction of the number of low-density lipoprotein receptors (LDLRs) on the surface of hepatocytes, which leads to an increase in the level of cholesterol in the blood. This mechanism and the fact that gain of function (GOF) mutations in PCSK9 are responsible for causing familial hypercholesterolemia whereas loss-of-function (LOF) mutations are associated with hypocholesterolemia, prompted the invention of drugs that block PCSK9 action. The high efficiency of PCSK9 inhibitors (e.g., alirocumab, evolocumab) in decreasing cardiovascular risk, pleiotropic effects of other lipid-lowering drugs (e.g., statins) and the multifunctional character of other proprotein convertases, were the cause for proceeding studies on functions of PCSK9 beyond cholesterol metabolism. In this article, we summarize the current knowledge on the roles that PCSK9 plays in different tissues and perspectives for its clinical use.

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“…Diabetes, a severe disease, also increases the risk of other conditions such as cardiovascular or chronic kidney diseases, causes disabilities such as blindness or lower limb amputation, reduces life expectancy, and poses a burden on health systems and social services [9][10][11][12]. Therefore, it is crucial to identify all risk factors for diabetes, because their modification could reduce morbidity or alleviate the course of this disease.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and socioeconomic predictors of diagnosed and undiagnosed diabetes in oldest-old and younger Caucasian seniors: results from the PolSenior study

Puzianowska-Kuźnicka

Januszkiewicz-Caulier

Kuryłowicz

et al. 2021

Endokrynologia Polska

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Introduction: Type 2 diabetes is one of the most common diseases in the aging population; however, data concerning correlates of diabetes in age-advanced individuals are limited. The study aimed to identify the socioeconomic correlates of diabetes in representative groups of oldest-old (≥ 85 years) and younger (65 to 84 years) Polish Caucasian seniors. Material and methods:PolSenior is a multicentre, population-based study conducted in Poland. Fasting plasma glucose levels and data from detailed medical questionnaires were obtained from 2128 male and 1961 female study participants aged ≥ 65 years. Multivariate logistic regression was used to identify significant socioeconomic risk factors for diabetes and undiagnosed diabetes. Results:The overall prevalence of diabetes in the study group was 21.9% (24.0% in women vs. 19.9% in men, p = 0.002), with an estimated weighted prevalence for all older Poles of 23.1%. Nearly one-fifth of cases were previously undiagnosed. Diabetes was more common in the younger elderly (65-84 years) than in the oldest-old (≥ 85 years) (23.4% vs. 18.6%, p < 0.001). The frequency of diabetes was higher in women than in men (24.0% vs. 19.9%, p < 0.002); however, men remained undiagnosed more commonly than women (4.7% vs. 3.3%, p = 0.029). The frequency of diabetes was higher among urban than rural dwellers (23% vs. 20.4%, p = 0.048). It was also related to marital status in women (p = 0.036) and occupation in men (p = 0.015). Multivariate logistic regression analysis revealed that the independent risk factors for diabetes were body mass index (BMI) and marital status in women, while in men it was solely BMI. Undiagnosed diabetes was more frequent among rural than city dwellers (4.8% vs. 3.5%, p = 0.03). In multivariate logistic regression analysis, only BMI and place of residence remained significant risk factors for being undiagnosed. Conclusions:The prevalence of diabetes in the ≥ 65-year-old population exceeds 20% but is lower in the oldest-old than in the younger elderly and is modified by socioeconomic factors.Many elderly individuals remain undiagnosed and do not benefit from the currently available therapy.

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Endocrine diseases as causes of secondary hyperlipidemia

Cited by 22 publications

References 68 publications

Mechanism of Astragalus membranaceus Alleviating Acquired Hyperlipidemia Induced by High-Fat Diet through Regulating Lipid Metabolism

Mechanism of Astragalus membranaceus Alleviating Acquired Hyperlipidemia Induced by High-Fat Diet through Regulating Lipid Metabolism

Insight into the Evolving Role of PCSK9

Prevalence and socioeconomic predictors of diagnosed and undiagnosed diabetes in oldest-old and younger Caucasian seniors: results from the PolSenior study

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