Endocrine changes in histiocytosis of the hypothalamic–pituitary axis

Galván, Silvia Toro; Vilaseca, Alejandra Planas; Alevras, Theodora Michalopoulou; Díaz, Alberto Torres; Balaguer, Javier Suárez; Artero, Carles Villabona

doi:10.1016/j.endoen.2015.02.003

Cited by 7 publications

(4 citation statements)

References 26 publications

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“…Some previous studies have shown that the prevalence of DI in patients with LCH has been found to be greater than 40%, approaching 94% in the presence of another hormonal deficiency. Although DI usually develops within 1 year from the diagnosis of LCH, it may occasionally precede the diagnosis 38 . In some large series, DI was the first symptom of LCH, manifesting up to 6 years earlier than LCH diagnosis 26,38,48 .…”

Section: Discussionmentioning

confidence: 99%

“…Although DI usually develops within 1 year from the diagnosis of LCH, it may occasionally precede the diagnosis 38 . In some large series, DI was the first symptom of LCH, manifesting up to 6 years earlier than LCH diagnosis 26,38,48 . Diabetes insipidus is also often the first endocrine manifestation in ECD, a disorder that resembles LCH, with a clinically sudden onset and symptomatic manifestation; when present, it is permanent, irrespective of the evolution of ECD.…”

Section: Discussionmentioning

confidence: 99%

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Diabetes insipidus secondary to sellar/parasellar lesions

Angelousi

Mytareli

Xekouki

et al. 2021

J Neuroendocrinology

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Diabetes insipidus (DI) is a well‐recognised transient or permanent complication following transsphenoidal surgery for pituitary adenomas or other sellar/parasellar lesions. However, data regarding the prevalence of pre‐operative DI in sellar/parasellar lesions other than pituitary adenomas are scarce. We systematically reviewed the existing data for defining the prevalence of DI before any treatment in adult patients with sellar/parasellar lesions, excluding pituitary adenomas and metastatic lesions. In total, 646 patients with sellar/parasellar lesions presenting with DI at diagnosis were identified. The most common pathologies of sellar/parasellar lesions presenting with DI at diagnosis were lymphocytic hypophysitis (26.5%), craniopharyngiomas (23.4%), Langerhans's cell histiocytosis (18.9%) and Rathke's cleft cyst (12.7%), accounting for the vast majority (more than 80%) of these lesions. Overall, DI at diagnosis was found in 23.4% of all patients with sellar/parasellar lesions, albeit with a wide range from 10.6% to 76.7%, depending on the nature of the pathology. The highest prevalence of DI was found in less commonly encountered lesions namely germ‐cell tumours (76.7%), abscesses (55.4%) and neurosarcoidosis (54.5%), each accounting for less than 3% of all sellar/parasellar lesions. Most DI cases (68.8%) were associated with anterior pituitary hormonal deficiencies, in contrast to pituitary adenomas that rarely present with DI. The enlargement and enhancement of the pituitary stalk were the most common findings on magnetic resonance imaging besides the loss of the high signal of the posterior pituitary on T1‐weighted images. Resolution of DI spontaneously or following systemic and surgical management occurred in 22.4% of cases. Post‐operative DI, not evident before surgery, was found in 27.8% of non‐adenomatous sellar/parasellar lesions, and was transient in 11.6% of them. Besides distinctive imaging features and symptoms, early recognition of DI in such lesions is important because it directs the diagnosis towards a non‐adenomatous sellar/parasellar tumour and the early initiation of appropriate treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Diabetes insipidus secondary to sellar/parasellar lesions

Angelousi

Mytareli

Xekouki

et al. 2021

J Neuroendocrinology

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“…Diabetes Insipidus (DI) is the most common CHL-related endocrine dysfunction and has been reported to occur in up to 30 % of affected patients, even so in almost half of patients with multisystem disorder (14,15).…”

Section: Discussionmentioning

confidence: 99%

Langerhans Cell Histiocytosis: an unusual cause of Diabetes Insipidus

Hadjkacem

Boujelben

Trimeche

et al. 2023

Preprint

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“…cindy.carvajal@live.com L as histiocitosis de células de Langerhans (HCL) son un grupo de enfermedades heterogéneas que presentan un comportamiento biológico variable y de etiología aún desconocida, su incidencia era alrededor 1 a 2 casos por 1 millón de habitantes, pero que ha ido en aumento en el último tiempo, presentándose con más frecuencia en adultos [1][2][3] . Sus manifestaciones clínicas son secundarias a la infiltración celular del sistema mononuclear fagocítico a diferentes órganos, que van desde lesiones indolentes hasta compromiso sistémico; el compromiso óseo es el más frecuente, sin embargo, en 25% presenta alteraciones endocrinas, estas alteraciones pueden aparecen tanto en el comienzo de la enfermedad como en el trascurso de ésta 4,5 . A continuación, presentamos un caso de un hombre joven que debutó con caída de múltiples piezas dentales como manifestación de HCL, pero que en el transcurso de su enfermedad cursó con panhipopituitarismo.…”

Section: La Histiocitosis De Células De Langerhans (Hcl) Es Una Enfer...unclassified

Histiocitosis de Langerhans y panhipopituitarismo en adulto. Reporte de caso

Carvajal Moya,

Díaz Aracena,

Zapata Pizarro

et al. 2023

Rev. méd. Chile

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Langerhans histiocytosis and panhypopituitarism in adults. Case reportLangerhans-cells Histiocytosis (LCH) is a rare disease characterized by the clonal proliferation of immature dendritic cells that locally or diffusely infiltrate different systems, mainly affecting children. We present the case of a 38-year-old man with a long-standing history of multiple tooth loss without association with trauma, smoking, or poor dental hygiene. Skull computed tomography (CT) showed multiple lytic jaw lesions. Jaw biopsy and immunohistochemical results were compatible with the finding of LCH. The patient evolved with polyuria, polydipsia, and nocturia, confirming the presence of diabetes insipidus and panhypopituitarism through hormonal studies. Magnetic resonance imaging (MRI) of the brain shows a hypothalamic neoplasm with infundibular involvement and an image suggestive of a pituitary granuloma. The treatment consisted of maxillobuccofacial defocusing, hormonal supplementation, chemotherapy, and radiotherapy with favorable evolution.

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Endocrine changes in histiocytosis of the hypothalamic–pituitary axis

Cited by 7 publications

References 26 publications

Diabetes insipidus secondary to sellar/parasellar lesions

Diabetes insipidus secondary to sellar/parasellar lesions

Langerhans Cell Histiocytosis: an unusual cause of Diabetes Insipidus

Histiocitosis de Langerhans y panhipopituitarismo en adulto. Reporte de caso

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