Endocrine, behavioral and autonomic effects of neuropeptide AF

Jászberényi, Miklós; Bagosi, Zsolt; Thurzó, Balázs; Földesi, Imre; Szabó, Gyula; Telegdy, Gyula

doi:10.1016/j.yhbeh.2009.02.006

Cited by 31 publications

(30 citation statements)

References 48 publications

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“…Telemetry monitoring of conscious laboratory animals has been proven useful in the acquisition of reliable physiological data, and it has many advantages over conventional methods of data collection (Ilback, Siller, & Stalhandske, 2008;Jaszberenyi et al, 2009). This method enables the detection of core temperature together with gross motor activity in freely moving, undisturbed animals.…”

Section: Introductionmentioning

confidence: 99%

Telemetry monitoring for non-invasive assessment of changes in core temperature after spinal drug administration in freely moving rats

Safrany-Fark

Petrovszki

Kekesi

et al. 2015

Journal of Pharmacological and Toxicological Methods

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Section: Introductionmentioning

confidence: 99%

Telemetry monitoring for non-invasive assessment of changes in core temperature after spinal drug administration in freely moving rats

Safrany-Fark

Petrovszki

Kekesi

et al. 2015

Journal of Pharmacological and Toxicological Methods

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“…This may favor the integrity of the individual (HPA response, self-maintenance) at the expense of inhibition of gonadotropins (reproduction) by prolactin [56] in a stressful environment. Perhaps kisspeptin and other RFamides may play a crucial, integrative role in these processes influencing dopamine and then, in turn, CRH and prolactin release [57][58][59][60]. Moreover, dopamine receptor downregulation, and consequent hyperprolactinemia may also aggravate HPA stimulation [23].…”

Section: Discussionmentioning

confidence: 99%

Evidence of the dopamine-2 receptor mediated inhibition of the hypothalamic-pituitary-adrenal system; a rodent model of hypercortisolism in chronic neuropsychiatric disorders

Thurzó¹,

Jászberényi²,

Bagosi³

et al. 2017

Transl Brain Rhythmicity

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The purpose of this study was to examine the role of dopaminergic mediation in the hypothalamic-pituitary-adrenal (HPA) response challenged by ether stress. First the effects of the D1 selective (SCH-23390) and the D2 selective (haloperidol) dopamine antagonists on ether stress evoked corticosterone responses were tested. The activation of the HPA axis was assessed by measuring plasma corticosterone levels. Low doses of haloperidol (25 nmol/kg, intraperitoneally) failed to affect either basal or stimulated corticosterone secretion, while SCH-23390 elicited moderate inhibition of stimulated release. However, to our surprise higher doses of haloperidol (250 nmol/kg) raised basal secretion and even potentiated the HPA response evoked by ether stress. Therefore to elucidate the role of D 2 mediation, the intrinsic activity of the D 2 antagonist was tested in further experiments. Haloperidol (from 25 nmol/kg to 2.5 mmol/kg) alone elicited a dose-dependent activation of the HPA system reflected by both corticosterone and ACTH serum levels. This D 2 -antagonist-evoked HPA activation could be prevented by pre-administration of the CRH antagonist, α-helical CRH 9-41 . These findings provide unequivocal evidence that D 2 receptor can exert inhibitory control over the HPA axis.

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“…Furthermore, a recent study found that kisspeptins can bind to the NPFF2R [121]. Accordingly, in our previous experiments, NPAF, a potent NPFF2R ligand, also stimulated the HPA axis [79]. NPAF was most effective at the dose of 0.5 µg, whereas it was the 2 µg dose of KP-13 that elicited the greatest response.…”

Section: Discussionmentioning

confidence: 59%

“…Neuropepide AF (NPAF), on the other hand, also induces the HPA axis and locomotor activity. It causes a decrease in the heart rate and core temperature [79]. These discrepancies between the biological actions of the individual peptides may be attributed to the difference in their receptor selectivity and/or place of release and action.…”

Section: The Rf-amide Family and The Discovery Of Kisspeptinmentioning

confidence: 99%

“…However, cell type-dependently other signal transduction cascades might also mediate the effect of kisspeptins such as mitogen activated protein kinase (MAPK), calcineurin and NFκB [25]. It must also be mentioned that recent evidence suggests that kisspeptin, beside the KISS1R, also activates the neuropeptide FF2 receptor (NPFF2R) [26], which have been implicated on autonomic, endocrine, behavioural and nociceptive processes [79,165].…”

Section: Structure Of Kisspeptins and Their Receptor Targetsmentioning

confidence: 99%

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Kisspeptin modulates the activity of the stress system and associated behaviours, the body temperature and nociception

Csabafi¹

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Endocrine, behavioral and autonomic effects of neuropeptide AF

Cited by 31 publications

References 48 publications

Telemetry monitoring for non-invasive assessment of changes in core temperature after spinal drug administration in freely moving rats

Telemetry monitoring for non-invasive assessment of changes in core temperature after spinal drug administration in freely moving rats

Evidence of the dopamine-2 receptor mediated inhibition of the hypothalamic-pituitary-adrenal system; a rodent model of hypercortisolism in chronic neuropsychiatric disorders

Kisspeptin modulates the activity of the stress system and associated behaviours, the body temperature and nociception

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