Endocrine Basis for Recurrent Pregnancy Loss

Ke, Raymond W.

doi:10.1016/j.ogc.2013.10.003

Cited by 47 publications

(39 citation statements)

References 46 publications

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“…This has led to discordant incidences in women with RPL, varying from 12% to 28% 73–76. However, diagnostic tests for LPD are neither reproducible nor reliable and have not been validated in large studies, and are thus not recommended in clinical practice 2,7,75,76. There is also no consensus on the proposed management of LPD.…”

Section: Etiologiesmentioning

confidence: 99%

“…There is also no consensus on the proposed management of LPD. Besides treating the underlying cause, several therapeutic regimens have been used: ovulation induction, supplemental progesterone, supplemental progesterone and estrogen, and human chorionic gonadotropin 75–78. Progesterone supplementation is the most widely used treatment because of its availability, ease of administration, and tolerability.…”

Section: Etiologiesmentioning

confidence: 99%

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Recurrent pregnancy loss: current perspectives

Hachem

Crepaux

May‐Panloup

et al. 2017

IJWH

337

209

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Recurrent pregnancy loss is an important reproductive health issue, affecting 2%–5% of couples. Common established causes include uterine anomalies, antiphospholipid syndrome, hormonal and metabolic disorders, and cytogenetic abnormalities. Other etiologies have been proposed but are still considered controversial, such as chronic endometritis, inherited thrombophilias, luteal phase deficiency, and high sperm DNA fragmentation levels. Over the years, evidence-based treatments such as surgical correction of uterine anomalies or aspirin and heparin for antiphospholipid syndrome have improved the outcomes for couples with recurrent pregnancy loss. However, almost half of the cases remain unexplained and are empirically treated using progesterone supplementation, anticoagulation, and/or immunomodulatory treatments. Regardless of the cause, the long-term prognosis of couples with recurrent pregnancy loss is good, and most eventually achieve a healthy live birth. However, multiple pregnancy losses can have a significant psychological toll on affected couples, and many efforts are being made to improve treatments and decrease the time needed to achieve a successful pregnancy. This article reviews the established and controversial etiologies, and the recommended therapeutic strategies, with a special focus on unexplained recurrent pregnancy losses and the empiric treatments used nowadays. It also discusses the current role of preimplantation genetic testing in the management of recurrent pregnancy loss.

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Section: Etiologiesmentioning

confidence: 99%

Section: Etiologiesmentioning

confidence: 99%

Recurrent pregnancy loss: current perspectives

Hachem

Crepaux

May‐Panloup

et al. 2017

IJWH

337

209

View full text Add to dashboard Cite

show abstract

“…La corré lation entre la pré sence d'anticorps antithyroïdiens et les FCS à ré pé tition est dé sormais bien é tablie [80,81], avec un odds ratio entre 2,3 et 2,7 selon les é tudes [55,59]. La responsabilité directe des anti-TPO n'est pas claire et certaines é quipes suspectent plutô t la responsabilité d'un terrain auto-immun ou d'inadaptation de la glande thyroïde en cas de grossesse, la pré sence d'anti-TPO pré disposant à l'hypothyroïdie [82].…”

Section: Fcs à Re´pe´titionunclassified

Impact du fonctionnement thyroïdien sur la fertilité du couple

Gronier¹,

Sonigo²,

Jacquesson³

2015

Gynécologie Obstétrique & Fertilité

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“…This not only causes significant physical and mental problems in families, but also a heavy economic burden on families and health systems (Gao et al, 2015;Vaiman et al, 2015). Although many causes (uterine abnormalities, endocrine disorders, genetic disorders, coagulation disorders and environmental factors, such as chemicals, and psychological factors) have been proposed as an etiology of RSA, the exact cause for much of RSA, named unexplained recurrent spontaneous abortion (URSA), remains unknown (Galamb et al, 2015;Ke, 2014;Ali et al, 2014;Cao et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Effect of Vitamin D Supplementation on Unexplained Recurrent Spontaneous Abortion: A Double-Blind Randomized Controlled Trial

Samimi¹,

Foroozanfard²,

Amini³

et al. 2016

GJHS

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Background: Recurrent spontaneous abortion is a serious problem in pregnancy, which affects between 2 and 5% of women of reproductive age. This study was designed to examine the effect of vitamin D supplementation on the occurrence of unexplained recurrent spontaneous abortion (URSA). Methods:A double-blind randomized and controlled clinical trial was performed on 80 patients with URSA. They were treated with vaginal progesterone (400 IU/day) after confirmation of pregnancy and received vitamin D and placebo in two intervention (n=40) and control groups (n=40), respectively. The incidence of abortion and the serum levels of IL-23 were examined within 20 weeks of gestation. Results:The levels of vitamin D3 prior to the start of the study were equal to 11.65±3.76 ng/ml and 11.53±2.39 ng/ml (p=0.86) in the intervention and control groups, respectively, which were decreased to 13.21±3.47 ng/ml and 11.08±2.76 ng/ml (p=0.004) at the end of the study, when the mean serum levels of IL-23 were equal to 18.4±3.78 pg/ml and 23.16±4.74 pg/ml in the two groups (p <0.004). The frequency of abortion in the control and intervention groups was equal to 5 (12.8%) and 13 (34.2%), respectively (p=0.03, OR=3.53, 95% CI= 1.12-11.2). Conclusions:Vitamin D3 leads to decreased serum levels of IL-23 and incidence of abortion among women with URSA.

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Endocrine Basis for Recurrent Pregnancy Loss

Cited by 47 publications

References 46 publications

Recurrent pregnancy loss: current perspectives

Recurrent pregnancy loss: current perspectives

Impact du fonctionnement thyroïdien sur la fertilité du couple

Effect of Vitamin D Supplementation on Unexplained Recurrent Spontaneous Abortion: A Double-Blind Randomized Controlled Trial

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