Endocrine Aspects of Argentaffinoma

Macfarlane, Peter S.; Dalgliesh, C. E.; Dutton, Richard; Lennox, Bernard; Nyhus, Lloyd M.; Smith, A. N.

doi:10.1177/003693305600100402

Cited by 121 publications

(19 citation statements)

References 22 publications

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“…The 24-hour histamine output in the urine was on one occasion 7.0 pg./24 hours. This amount is in the lower range of normal histamine excretion (Roberts and Adam, 1950), and is in contrast to the value of 1,100, 1,800. and 3,600 pg./24 hours reported by Macfarlane et al (1956) in 3 of their 19 cases.…”

Section: Progressmentioning

confidence: 76%

“…determinations were regularly done on 24-hour urine samples for a period of two weeks. The urine excretion varied from 75 to 150 mg./24 hours, a figure greatly in excess of 7 mg./24 hours found to be the mean excretion in a group of normal controls (Macfarlane et al, 1956). The 24-hour histamine output in the urine was on one occasion 7.0 pg./24 hours.…”

Section: Progressmentioning

confidence: 92%

“…In the Blood The excretion of 5-H.I.A.A. in the urine was detcrmined by the method described by Macfarlane et al (1956) and the concentration of 5-R.T. in the blood by that described by Hardisty and Stacey (1955). Urinary histamine was determined by the method of Roberts and Adam (1950).…”

Section: Progressmentioning

confidence: 99%

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Metastatic Argentaffinoma Secreting 5-Hydroxytryptamine in a Patient with a Patent Foramen Ovale

Wolfe¹,

Davies²,

Mathias³

et al. 1960

BMJ

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Section: Progressmentioning

confidence: 76%

Section: Progressmentioning

confidence: 92%

See 1 more Smart Citation

Metastatic Argentaffinoma Secreting 5-Hydroxytryptamine in a Patient with a Patent Foramen Ovale

Wolfe¹,

Davies²,

Mathias³

et al. 1960

BMJ

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“…The liver was 9 cm enlarged below the costal margin, hard and irregular. There was slight pitting oedema of the feet.Investigations included the estimation of the 24-hour urinary excretion of 5-hydroxyindoleacetic acid (5 HIAA) [2]. The result was 40 mg/24 h and after chlorpromazine 43 mg/24 h. (Normal values 3.2 -13.7 mg.) Paper chromatography revealed increased quantities of 5-hydroxytryptamine (5 HT) and 5 HIAA.…”

mentioning

confidence: 99%

The Carcinoid Syndrome in an Elderly Woman

Fisher¹,

Hussain²

1971

Geront clin

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“…Urinary excretion of 5-hydroxyindoleacetic acid was estimated on pooled rat urine by the method of Marfarlane, Dalgliesh, Dutton, Lennox, Nyhus & Smith (1956), after collection of urine from rats in metabolism cages for 16 to 18 hr overnight. Urinary creatinine was estimated by the method of Folin (1914).…”

mentioning

confidence: 99%

Effect of Antibiotics on the 5‐hydroxytryptamine Content of the Small Intestine and Other Organs in Rats and Mice

Sullivan¹

1961

British Journal of Pharmacology and Chemotherapy

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Rats and mice were given antibiotics orally and by subcutaneous injection and the effects on tissue levels of 5-hydroxytryptamine and intestinal bacteria were studied. In mice it was found that antibiotics which caused a large reduction in the bacterial flora of the intestine when given orally also caused a significant increase in intestinal 5-hydroxytryptamine. In rats, neomycin caused a reduction in the urinary excretion of 5-hydroxyindoleacetic acid. In both rats and mice, many antibiotics caused a significant reduction in the weight of the spleen.Stacey & Sullivan (1957) reported that the intestinal content of 5-hydroxytryptamine in mice was raised after oral administration of a combination of streptomycin and chlortetracycline. They found that rectal swabs from treated mice taken on the day of death were sterile, and suggested that sterilization of the gut might have increased the amount of tryptophan available for 5-hydroxytryptamine synthesis by preventing the bacterial metabolism of dietary tryptophan. The present paper reports further experiments undertaken to amplify these results. METHODSGroups of adult male mice weighing 20 to 30 g and of rats weighing 130 to 180 g were matched according to weight and age, and were litter-mates where possible. Control and treated groups received a mixed, balanced diet in cubes, and water ad lib.Antibiotics were given twice daily either orally by stomach tube or by subcutaneous injection. The doses used, roughly five times the adult human therapeutic dose in mg/kg, were as follows:(1) Neomycin, 215 mg/kg, for rats and mice. Solution for rats 50 mg/ml. and for mice 25 mg/ml. (2) Streptomycin, 70 mg/kg in a solution of 10 mg/ml. for all animals. (3) Chlortetracycline and oxytetracycline, 70 mg/kg, in a solution of 10 mg/ml. for all animals. (4) Chloramphenicol, 105 mg/kg, in a solution of 15 mg/ml. for all animals.When combinations of antibiotics were used, the same doses of the individual drugs were given. Solutions of drugs were made up, when necessary, in normal saline. Controls were given the same volume of normal saline.Animals were killed by stunning and bleeding. The whole of the spleen and brain was homogenized and aliquots taken for assay of 5-hydroxytryptamine in both rats and mice. The small intestine of mice, from the pyloric sphincter to the ileo-caecal junction, was similarly treated. The mucous membrane of the small intestine of rats was scraped off with a scalpel

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Endocrine Aspects of Argentaffinoma

Cited by 121 publications

References 22 publications

Metastatic Argentaffinoma Secreting 5-Hydroxytryptamine in a Patient with a Patent Foramen Ovale

Metastatic Argentaffinoma Secreting 5-Hydroxytryptamine in a Patient with a Patent Foramen Ovale

The Carcinoid Syndrome in an Elderly Woman

Effect of Antibiotics on the 5‐hydroxytryptamine Content of the Small Intestine and Other Organs in Rats and Mice

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