Endocrine activity of mycotoxins and mycotoxin mixtures

Demaegdt, Heidi; Daminet, Britt; Evrard, Annick; Scippo, Marie‐Louise; Müller, Marc; Pussemier, Luc; Callebaut, Alfons; Vandermeiren, K.

doi:10.1016/j.fct.2016.07.033

Cited by 37 publications

(33 citation statements)

References 44 publications

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“…In this study, E 2 strongly induced oestrogenic response with an EC 50 value of 0.053 ± 0.012 nM which is similar to most previously reported EC 50 values of E 2 using different assay methods (Jobling et al, 1995;Balaguer et al, 1996;Sonneveld et al, 2005;Brennan et al, 2016). However, this EC 50 value of E 2 (0.053 ± 0.012 nM) was slightly higher than the ones reported by Frizzell et al (2011) and Demaegdt et al (2016) (Frizzell et al, 2011;Molina-Molina et al, 2014;Ehrlich et al, 2015;Drzymala et al, 2015;Demaegdt et al, 2016). Although the ranking of oestrogenicity of ZEN and α-ZOL was similar to report of previous studies, the EC 50 values (ZEN: 1.32 ± 0.0956 nM and α-ZOL: 0.27 ± 0.121 nM) varied from those reported by Frizzell et al (2011) and Demaegdt et al (2016) using the same reporter cell line.…”

Section: Accepted Manuscriptsupporting

confidence: 88%

“…Research into the effects of mycotoxins, including ZEN, α-ZOL and β-ZOL on ER transcriptional activity has traditionally focused on the effects of single toxins (Kuiper et al, 1998;Shier et al, 2001;Frizzell et al, 2011;Cozzini et al, 2012;Molina-Molina et al, 2014;Ehrlich et al, 2015;Drzymala et al, 2015) while only a few studies have assessed the effects mixtures of these toxins may have on ER transcriptional activity (Demaegdt et al, 2016;Vejdovszky et al, 2017aVejdovszky et al, , 2017b. However, multiple mycotoxin exposure is the rule and not the exception.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

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The effect of individual and mixtures of mycotoxins and persistent organochloride pesticides on oestrogen receptor transcriptional activation using in vitro reporter gene assays

Eze

Huntriss

Routledge

et al. 2019

Food and Chemical Toxicology

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Section: Accepted Manuscriptsupporting

confidence: 88%

Section: Accepted Manuscriptmentioning

confidence: 99%

The effect of individual and mixtures of mycotoxins and persistent organochloride pesticides on oestrogen receptor transcriptional activation using in vitro reporter gene assays

Eze

Huntriss

Routledge

et al. 2019

Food and Chemical Toxicology

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“…The presence of small amounts of mycotoxins with endocrine activity [ 32 ], including mycoestrogens such as ZEN, in food and feed can provoke different KEs than high doses in initial stages of exposure [ 15 ]. Earlier KEs can induce a cascade of other events, which are resolved without any intervention, are not accompanied by clinical symptoms [ 33 ] or can be the first symptom of an undesirable effect.…”

Section: Introductionmentioning

confidence: 99%

Activity of Zearalenone in the Porcine Intestinal Tract

Gajęcka

Zielonka

2016

Molecules

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This study demonstrates that low doses (somewhat above the No Observed Adverse Effect Level, NOAEL) of the mycoestrogen zearalenone (ZEN) and its metabolites display multispecificity towards various biological targets in gilts. The observed responses in gilts were surprising. The presence of ZEN and zearalenols (ZELs) did not evoke a response in the porcine gastrointestinal tract, which was attributed to dietary tolerance. Lymphocyte proliferation was intensified in jejunal mesenteric lymph nodes, and lymphocyte counts increased in the jejunal epithelium with time of exposure. In the distal digestive tract, fecal bacterial counts decreased, the activity of fecal bacterial enzymes and lactic acid bacteria increased, and cecal water was characterized by higher genotoxicity. The accompanying hyperestrogenism led to changes in mRNA activity of selected enzymes (cytochrome P450, hydroxysteroid dehydrogenases, nitric oxide synthases) and receptors (estrogen and progesterone receptors), and it stimulated post-translational modifications which play an important role in non-genomic mechanisms of signal transmission. Hyperestrogenism influences the regulation of the host’s steroid hormones (estron, estradiol and progesteron), it affects the virulence of bacterial genes encoding bacterial hydroxysteroid dehydrogenases (HSDs), and it participates in detoxification processes by slowing down intestinal activity, provoking energy deficits and promoting antiporter activity at the level of enterocytes. In most cases, hyperestrogenism fulfils all of the above roles. The results of this study indicate that low doses of ZEN alleviate inflammatory processes in the digestive system, in particular in the proximal and distal intestinal tract, and increase body weight gains in gilts.

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“…Diet quality may affect NCD independent of body weight or obesity (8) . Factors including exposure to environmental pollutants and microbial toxins may play a role, but the mechanisms linking these to NCD are yet to be fully understood to enable targeted action (14)(15)(16)(17)(18) . Countries are responding at varying paces to the NCD menace by putting in place policy frameworks that address some of its key driving factors including, school-based nutrition education, taxation on cigarettes, alcohol and sugar-sweetened beverages, laws to enable mandatory reformulation of food products, and regulations on marketing and advertising of food products to children (8,9,19,20) .…”

mentioning

confidence: 99%

Challenges and opportunities to tackle the rising prevalence of diet-related non-communicable diseases in Africa

Owino

2019

Proc. Nutr. Soc.

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Africa is experiencing a sharp rise in non-communicable diseases (NCD) related to rapid globalisation and urbanisation leading to shifts in dietary and lifestyle patterns characterised by increased energy intake and physical inactivity. However, unlike more resource-endowed regions, Africa has a double burden of disease: NCD co-exist with infectious diseases including lower respiratory tract infections, HIV/AIDS and diarrhoeal diseases. The African economy is also relatively weaker, making it difficult to cope with this burden. It is postulated that NCD will soon overtake infectious diseases as the number one cause of death in the African region. The recognition of NCD as diseases and obesity as a related risk factor is weak in Africa, compounded by stigma associated with wasting in HIV/AIDS and obesity being perceived as a sign of wealth, achievement and care. There is also a dearth of data on overweight and obesity in the region and little knowledge that infant feeding practices, such as breast-feeding, are linked to reduced risk of NCD in both children and mothers. While complex multi-sectoral approaches to address this NCD menace are needed, Africa may benefit from taking simple initial steps to address NCD risk factors including: (1) behaviour change communication to challenge perceptions on NCD; (2) promoting and protecting breast-feeding; (3) formulating policies and regulations limiting wide availability of unhealthy foods; (4) mainstream nutrition education in school curricula and (5) collection of accurate data based on indicators that can reflect the double burden of disease and malnutrition; and fostering multi-sectoral actions against NCD.

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Endocrine activity of mycotoxins and mycotoxin mixtures

Cited by 37 publications

References 44 publications

The effect of individual and mixtures of mycotoxins and persistent organochloride pesticides on oestrogen receptor transcriptional activation using in vitro reporter gene assays

The effect of individual and mixtures of mycotoxins and persistent organochloride pesticides on oestrogen receptor transcriptional activation using in vitro reporter gene assays

Activity of Zearalenone in the Porcine Intestinal Tract

Challenges and opportunities to tackle the rising prevalence of diet-related non-communicable diseases in Africa

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