Endocrine activity in a large hibernoma

Allegra, Salvatore R.; Gmuer, Cecilia; O’Leary, Gerard

doi:10.1016/s0046-8177(83)80260-3

Cited by 29 publications

(20 citation statements)

References 9 publications

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“…Evidence shows that white adipocytes in patients with pheochromocytoma undergo direct transformation into brown adipocytes, which is associated with elevated thermogenesis and lower BMI in patients (Frontini et al, 2013). Body weight reduction has also been reported in patients with hibernoma due to ectopic de novo development of brown adipocytes (Allegra et al, 1983). However, the extent to which WAT browning contributes to weight loss is not clear until recently.…”

Section: Introductionmentioning

confidence: 90%

Inter-organ regulation of adipose tissue browning

Wang

Yang

2016

Cell. Mol. Life Sci.

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Adaptive thermogenesis is an important component of energy expenditure. Brown adipocytes are best known for their ability to convert chemical energy into heat. Beige cells are brown-like adipocytes that arise in white adipose tissue in response to certain environmental cues to dissipate heat and improve metabolic homeostasis. A large body of intrinsic factors and external signals are critical for the function of beige adipocytes. In this review, we discuss recent advances in our understanding of neuronal, hormonal, and metabolic regulation of the development and activation of beige adipocytes, with a focus on the regulation of beige adipocytes by other organs, tissues, and cells. Understanding the cellular and molecular mechanisms of inter-organ regulation of adipose tissue browning may provide an avenue for combating obesity and associated diseases.

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Section: Introductionmentioning

confidence: 90%

Inter-organ regulation of adipose tissue browning

Wang

Yang

2016

Cell. Mol. Life Sci.

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“…Physiologically, the requirement for nonshivering thermogenesis is limited by our other adaptations to environment (clothing and heating), although a study nearly 30 years ago showed at least one group of outdoor workers in Scandinavia to have increased BAT deposits. 18 Interestingly, b3-adrenoreceptor polymorphisms leading to a reduction in receptor function (notably the substitution of a tryptophan to an arginine residue at position 64) have been linked to weight gain, 19 as well as being positively associated with earlyonset type 2 diabetes. Brown fat tumours (or hibernomas, from their resemblance to adipose tissue in hibernating animals 17 ) are rare, benign and seemingly asymptomatic; though, significant weight loss has been associated with the tumour in at least one case report.…”

Section: Is There Functional Bat In Humans?mentioning

confidence: 99%

“…18 Interestingly, b3-adrenoreceptor polymorphisms leading to a reduction in receptor function (notably the substitution of a tryptophan to an arginine residue at position 64) have been linked to weight gain, 19 as well as being positively associated with earlyonset type 2 diabetes. 18 F-FDG-PET simply monitors glucose uptake, with highly metabolically active tissues being labelled; what this actually means can, of course, only be inferred. 2).…”

Section: Is There Functional Bat In Humans?mentioning

confidence: 99%

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Brown fat and obesity: the next big thing?

Stephens

Ludgate

Rees

2011

Clinical Endocrinology

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Brown adipose tissue (BAT) is well recognised to have an important role in the maintenance of body temperature in animals and human neonates, its thermogenic action affected by a tissue-specific uncoupling protein; fatty acid oxidation within the numerous brown adipocyte mitochondria is rendered inefficient leading to heat, rather than adenosine triphosphate (ATP), production. BAT was believed to show rapid involution in early childhood, leaving only vestigial amounts in adults. However, recent evidence suggests that its expression in adults is far more common than previously appreciated, with a higher likelihood of detection in women and leaner individuals. It is conceivable that BAT activity might reduce the risk of developing obesity since fat stores are used for thermogenesis, and a directed enhancement of adipocyte metabolism might have value in weight reduction. However, it is as yet unclear how such manipulation of BAT might be achieved; even in animal models, the control of thermogenic activity is incompletely understood. Even so, there is still much to interest the endocrinologist in BAT, with a range of hormones affecting adipocyte activity. This may either contribute to normal physiological function, or the phenotypical presentation of states of pathological hormone excess or deficiency. Thus, the gender differences in BAT distribution may be attributable to the differential effects of male and female sex hormones, whilst BAT expansion may drive the weight loss associated with catecholamine-producing phaeochromocytomas. These observations support an important influence of the endocrine system on BAT activity and offer new potential targets in the treatment of obesity.

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“…Approximately 100 patients with such growths, predominately in the neck, axilla, groin, mediastinum, retroperitoneal space, and in the vicinity of the pancreas and kidneys, have been reported. Other authors have noted that most hibernomas occur in young patients between their second and third decades, with a slight predominance in females [2][3][4][5].…”

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confidence: 99%