Endocrine active chemicals, pharmaceuticals, and other chemicals of concern in surface water, wastewater-treatment plant effluent, and bed sediment, and biological characteristics in selected streams, Minnesota: Design, methods, and data, 2009

Lee, Kathy E.; Langer, Susan K.; Barber, Larry B.; Writer, Jeff H.; Ferrey, Mark L.; Schoenfuss, Heiko L.; Furlong, Edward T.; Foreman, William T.; Gray, James L.; ReVello, Rhiannon C.; Martinović, Dalma; Woodruff, Olivia R.; Keefe, Steffanie H.; Brown, Greg K.; Taylor, Howard E.; Ferrer, Imma; Thurman, E. Michael

doi:10.3133/ds575

Cited by 26 publications

(90 citation statements)

References 11 publications

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“…The dominant land use in the 100-km 2 Redwood River watershed is agriculture (67% cropland and 19% grassland). 29 The surface geology consists of Quaternary glacial drift, primarily clayey till interdispersed with sand and gravel. 36 Other potential sources of EDCs upstream of the study reach include four small WWTPs that seasonally discharge effluent, an industrial facility processing agricultural products, and over 170 animal feeding operations.…”

Section: ■ Introductionmentioning

confidence: 99%

“…36 Other potential sources of EDCs upstream of the study reach include four small WWTPs that seasonally discharge effluent, an industrial facility processing agricultural products, and over 170 animal feeding operations. 29 Tracer Experiments. To establish basic hydrological flow conditions in the Redwood River and estimate hydrologic transit times, a preliminary pulsed tracer test was conducted on July 29, 2008.…”

Section: ■ Introductionmentioning

confidence: 99%

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Fate of 4-Nonylphenol and 17β-Estradiol in the Redwood River of Minnesota

Writer

Ryan

Keefe

et al. 2011

Environ. Sci. Technol.

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104

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The majority of previous research investigating the fate of endocrine-disrupting compounds has focused on single processes generally in controlled laboratory experiments, and limited studies have directly evaluated their fate and transport in rivers. This study evaluated the fate and transport of 4-nonylphenol, 17β-estradiol, and estrone in a 10-km reach of the Redwood River in southwestern Minnesota. The same parcel of water was sampled as it moved downstream, integrating chemical transformation and hydrologic processes. The conservative tracer bromide was used to track the parcel of water being sampled, and the change in mass of the target compounds relative to bromide was determined at two locations downstream from a wastewater treatment plant effluent outfall. In-stream attenuation coefficients (k(stream)) were calculated by assuming first-order kinetics (negative values correspond to attenuation, whereas positive values indicate production). Attenuation of 17β-estradiol (k(stream) = -3.2 ± 1.0 day(-1)) was attributed primarily due to sorption and biodegradation by the stream biofilm and bed sediments. Estrone (k(stream) = 0.6 ± 0.8 day(-1)) and 4-nonylphenol (k(stream) = 1.4 ± 1.9 day(-1)) were produced in the evaluated 10-km reach, likely due to biochemical transformation from parent compounds (17β-estradiol, 4-nonylphenolpolyethoxylates, and 4-nonyphenolpolyethoxycarboxylates). Despite attenuation, these compounds were transported kilometers downstream, and thus additive concentrations from multiple sources and transformation of parent compounds into degradates having estrogenic activity can explain their environmental persistence and widespread observations of biological disruption in surface waters.

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Section: ■ Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Fate of 4-Nonylphenol and 17β-Estradiol in the Redwood River of Minnesota

Writer

Ryan

Keefe

et al. 2011

Environ. Sci. Technol.

Self Cite

104

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“…The number of anthropogenic chemicals detected at the upstream locations was generally indicative of land-use and number of upstream WWTPs at the R and H sites. 12,14 The number of chemical pollutants in the effluent is likely related to the efficiency and treatment technology differences between larger and smaller WWTPs. Analysis of downstream locations showed more chemicals than those measured at upstream but lower than in the effluent, likely due to dilution, degradation, or adsorption.…”

Section: Environmental Science and Technologymentioning

confidence: 99%

“…For example, GarciaReyero et al 9 and Ing et al 10 both utilized a site upstream of an effluent discharge as the reference site, to provide a comparison that more closely represented ambient conditions. The current study (and its two associated studies 12,13 ) sought to expand on previous efforts by coupling many of the strongest elements of previous work, with extensive information about the site's chemical and physical nature, 14 and grounding the approach in established, sound ecotoxicological practice. We utilized laboratory reared fathead minnows (Pimephales promelas) to examine changes in the ovarian transcriptome following exposures to complex effluents.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Site demographics, land use, treatment systems, water quality, select chemicals, and targeted biological activity (i.e., primarily estrogenic activity) were evaluated one year prior to the present study (Table S1, Supporting Information). 14 Fish Exposures. At the specific locations (upstream, effluent, downstream), sexually mature female fathead minnows (SM2) were exposed to location specific water in mini-mobile environmental monitoring units (MMU) 15 for a period of 4 d, at each of three sites (R, H, E) during the summer and fall of 2010 (SM3).…”

Section: ■ Introductionmentioning

confidence: 99%

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Using Transcriptomic Tools to Evaluate Biological Effects Across Effluent Gradients at a Diverse Set of Study Sites in Minnesota, USA

Berninger¹,

Martinović-Weigelt²,

García-Reyero³

et al. 2014

Environ. Sci. Technol.

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The aim of this study was to explore the utility of "omics" approaches in monitoring aquatic environments where complex, often unknown stressors make chemical-specific risk assessment untenable. We examined changes in the fathead minnow (Pimephales promelas) ovarian transcriptome following 4-day exposures conducted at three sites in Minnesota (MN, USA). Within each site, fish were exposed to water from three locations along a spatial gradient relative to a wastewater treatment plant (WWTP) discharge. After exposure, site-specific impacts on gene expression in ovaries were assessed. Using an intragradient point of comparison, biological responses specifically associated with the WWTP effluent were identified using functional enrichment analyses. Fish exposed to water from locations downstream of the effluent discharges exhibited many transcriptomic responses in common with those exposed to the effluent, indicating that effects of the discharge do not fully dissipate downstream. Functional analyses showed a range of biological pathways impacted through effluent exposure at all three sites. Several of those impacted pathways at each site could be linked to potential adverse reproductive outcomes associated with the hypothalamic−pituitary−gonadal (HPG) axis in female fathead minnows, specifically signaling pathways associated with oocyte meiosis, TGF-beta signaling, gonadotropin-releasing hormone (GnRH) and epidermal growth factor receptor family (ErbB), and gene sets associated with cyclin B-1 and metalloproteinase. The utility of this approach comes from the ability to identify biological responses to pollutant exposure, particularly those that can be tied to adverse outcomes at the population level and those that identify molecular targets for future studies.

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Pharmaceuticals and other anthropogenic tracers in surface water: A randomized survey of 50 Minnesota lakes

Ferrey

Heiskary

Grace

et al. 2015

Enviro Toxic and Chemistry

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Water from 50 randomly selected lakes across Minnesota, USA, was analyzed for pharmaceuticals, personal care products, hormones, and other commercial or industrial chemicals in conjunction with the US Environmental Protection Agency's 2012 National Lakes Assessment. Thirty-eight of the 125 chemicals analyzed were detected at least once, all at parts per trillion concentrations. The most widely detected was N,N-diethyl-m-toluamide, present in 48% of the lakes sampled. Amitriptyline, a widely used antidepressant, was found in 28% of the lakes. The endocrine active chemicals bisphenol A, androstenedione, and nonylphenol were found in 42%, 30%, and 10% of the lakes, respectively. Cocaine was found in 32% of the lakes, and its degradation product, benzoylecgonine, was detected at 28% of the locations. Carbadox, an antibiotic used solely in the production of swine, was also present in 28% of the lakes sampled. The means by which these and other chemicals were transported to several of the remote lakes is unclear but may involve atmospheric transport.

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Endocrine active chemicals, pharmaceuticals, and other chemicals of concern in surface water, wastewater-treatment plant effluent, and bed sediment, and biological characteristics in selected streams, Minnesota: Design, methods, and data, 2009

Abstract: This report presents the study design, environmental data, and quality-assurance data for an integrated chemical and biological study of selected streams or lakes that receive wastewater-treatment plant effluent in Minnesota. This study

Cited by 26 publications

References 11 publications

Fate of 4-Nonylphenol and 17β-Estradiol in the Redwood River of Minnesota

Fate of 4-Nonylphenol and 17β-Estradiol in the Redwood River of Minnesota

Using Transcriptomic Tools to Evaluate Biological Effects Across Effluent Gradients at a Diverse Set of Study Sites in Minnesota, USA

Pharmaceuticals and other anthropogenic tracers in surface water: A randomized survey of 50 Minnesota lakes

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