Endocrine Abnormalities and Fatigue After Traumatic Brain Injury

Predicting Fatigue 12 Months after Child Traumatic Brain Injury: Child Factors and Postinjury Symptoms

“…These include neuroanatomical, functional, psychological, bio-chemical, endocrine, and sleep-related causes, occurring independently or in combination after TBI (Mollayeva et al, 2014). While biological, psychological, and social factors have all been considered to exert bidirectional influences on fatigue (Chaudhuri & Behan, 2000;Elovic, 2003Elovic, , 2004Elovic, Dobrovic, & Fellus, 2007;Elovic et al, 2006), the specific relationships are yet to be examined in child TBI. The brain basis to fatigue is poorly understood, although in adults, the basil ganglia [and hypothalamic-pituitary-adrenal (HPA) axis] are likely candidates (Chaudhuri & Behan, 2000; for a review see Elovic et al, 2007).…”