EndoClot Polysaccharide Hemostatic System in Nonvariceal Gastrointestinal Bleeding

Abstract

EndoClot expanded the therapeutic options in the management of GI bleeding. It was applicable as a monotherapy or in combination with other techniques from oozing bleeding type or lower. It was most effective in diffuse or extensive bleeding activity or when access to the bleeding vessel was difficult. EndoClot can be applied as a bridge to surgery when classical methods of hemostasis have failed.

Efficacy of hemostatic powder in preventing bleeding after gastric endoscopic submucosal dissection in high‐risk patients

“…AMP® particles absorb water to form a gelled matrix that shields the ulcer surface for 3-48 h and causes a local concentration of coagulating factors. 20,36 In previous animal studies, polysaccharide hemostatic powder derived from modified starch could improve impaired wound healing 37 and was able to stop active ulcer bleeding from iatrogenic mucosal ulcers by snaring in pigs receiving antithrombotic therapy. Compared to the mechanical methods such as overstitch endoscopic suturing device, detachable snare, and clips, Endo-Clot ™ is more easy to use and there is no further tissue injury to the post-resection ulcer surface because the catheter of Endo-Clot ™ does not need to directly contact the ulcer surface.…”

“…Endo‐Clot™ is biocompatible absorbable hemostatic polysaccharides. AMP® particles absorb water to form a gelled matrix that shields the ulcer surface for 3–48 h and causes a local concentration of coagulating factors . In previous animal studies, polysaccharide hemostatic powder derived from modified starch could improve impaired wound healing and was able to stop active ulcer bleeding from iatrogenic mucosal ulcers by snaring in pigs receiving antithrombotic therapy.…”

“…8,19 Polysaccharide hemostatic powder (Endo-Clot ™ ) is a new topical hemostatic method recently used for non-variceal upper gastrointestinal bleeding. 20 To date, there has been no prospective study about the safety and efficacy of hemostatic powder in preventing post-ESD bleeding in the stomach.…”

Role of hemostatic powders in the management of lower gastrointestinal bleeding: A review

“…A few cases have been reported in the literature about the use of this modality with very good success rate. Hemospray was used in four cases of tumors at various sites of the colon as primary or salvage therapy, and EndoClot was successfully used in one patient with sigmoid colon tumor followed by surgery . In addition, ABS as primary treatment was able to achieve hemostasis within seconds in five patients with rectal carcinoma with no adverse events reported (Table ).…”

Endoscopy for upper gastrointestinal bleeding: where are we in 2017?

“…In case studies, it has shown promise as an effective haemostatic modality as a monotherapy, in combination with conventional modalities or as a rescue modality following failure of standard endotherapy. It may also be useful in diffuse areas of bleeding, for example, from a malignant tumour 18 19…”