Endocervical and Cervical Neoplasms Adjacent to Carcinoma<i>In Situ</i>

Melnick, P. J.; Lee, Lyndon E.; Walsh, Harry M.

doi:10.1093/ajcp/28.4.354

Cited by 13 publications

(3 citation statements)

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“…Friedell and McKay5 were the first to identify and describe AIS as a distinct entity within a histologic specimen that also contained HGSIL. Since that report, numerous retrospective studies and case reports dealing with combined cervical squamous and glandular cell lesions, mixed adenosquamous carcinoma in situ,6–19 and mixed adenosquamous carcinoma have been published 20–30…”

Section: Introductionmentioning

confidence: 99%

Severe cervical glandular cell lesions with coexisting squamous cell lesions

Erp

Smedts²,

Vooijs³

2004

Cancer

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BACKGROUND. In the current report, the authors present the results of a reevaluation of cytologic smears and histologic specimens obtained from patients with severe cervical glandular cell lesions (adenocarcinoma in situ [AIS] or adenocarcinoma [ADCA] of the cervix) and coexisting Grade 1, Grade 2, or Grade 3 cervical intraepithelial neoplasia or squamous cell carcinoma. The goal of the current study was to assess whether knowledge of the specific cytologic characteristics of the cervical glandular cell lesions could have made the cytologic diagnosis of these combined neoplasms more accurate. METHODS. Cytologic smears and histologic specimens obtained from 36 patientswith combined severe cervical lesions were evaluated for the presence of a range of microscopic cytologic and histologic features that were considered indicative of glandular cell changes. RESULTS.The findings of the current study suggest that the proper identification of characteristic cytomorphologic features of cervical glandular lesions would have resulted in more accurate diagnoses of combined severe cervical lesions. In the set of samples reevaluated by the authors, consideration of these features would have increased the accuracy of cytologic diagnosis from 55.6% to 75.0%. The presence of AIS was predicted in the majority of cytologic specimens, and in most cases, the identity of the predominant subtype of AIS could also be predicted. CONCLUSIONS.The current analysis revealed that consideration of specific cytomorphologic features of glandular lesions of the cervix increased the authors' accuracy in diagnosing combined severe lesions of the cervix. More accurate identification of intraepithelial glandular cell lesions may eventually lead to decreases in cervical adenocarcinoma incidence, just as increases in diagnostic accuracy have led to decreases in the incidence of squamous intraepithelial lesions and invasive squamous carcinoma of the cervix.

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Section: Introductionmentioning

confidence: 99%

Severe cervical glandular cell lesions with coexisting squamous cell lesions

Erp

Smedts²,

Vooijs³

2004

Cancer

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“…Adenocarcinoma in situ of the columnar epithelium of the endocervix (AH) is an easily overlooked lesion (Melnick, Lee & Walsh 1957, Werner & Waidecker 1972, Sachs, Tkeda & Brachetti 1975, Christopherson, Nealon & Gray 1979. One way to detect it is to review cases of epidermoid carcinoma irz situ (CIS) and scrutinize the columnar epithelium (Qizilbash 1975).…”

Section: Introductionmentioning

confidence: 99%

“…One way to detect it is to review cases of epidermoid carcinoma irz situ (CIS) and scrutinize the columnar epithelium (Qizilbash 1975). Cases have been published reporting the co-existence of cancerous glandular and squamous lesions of the cervix (Glucksmann 1957, Dougherty & Cotten 1964, Christopherson et al 1979, Maier & Norris 1980 and the co-existence of precancerous glandular and squamous lesions of the cervix Friedell & McKay 1953, Glucksmann 1975, Melnick et al 1957, Abell & Gosling 1962, Steiner & Freidell 1965, Lauchlan & Penner 1967, Weisbrot, Stablinsky & Davis, 1972, Alva & Lauchlan 1975, Wolk, Kime & Albites 1981. The importance of the possible role of the reserve cell as the precursor of both columnar and squamous cervical lesions of the cervix and has been suggested (Johnson et al 1964, Lauchlan & Penner 1967, Aha & Lauchlan 1975, Beyer-Boon & Verdonk 1978, Ruiter & Boon 1982.…”

Section: Introductionmentioning

confidence: 99%

The association between precancerous‐columnar and squamous lesions of the cervix: a morphometric study

Roon¹,

Boon²,

Kurver³

et al. 1983

Histopathology

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A histological study of 208 cases found a strong association between the occurrence of precancerous cervical columnar and squamous lesions. This was not, however, directly related to cellular abnormalities. The criteria for adenocarcinoma in situ (AIS) and its precursor lesions were defined morphometrically. With increasing abnormalities of the columnar cells, changes of the glandular and epithelial architecture were more frequently observed. Of the 20 cases morphometrically classified as AIS, only four were initially diagnosed as such, of which three were cases of 'pure' AIS lacking squamous cell abnormalities. Quantifying abnormalities of columnar epithelium is an important aid in the identification and classification of AIS.

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Noninvasive precursor lesions of adenocarcinoma and mixed adenosquamous carcinoma of the cervix uteri

Christopherson

Nealon

Gray

1979

Cancer

133

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It is postulated that squamous cell carcinoma, adenocarcinoma, and mixed adenosquamous cell carcinoma of the uterine cervix all have a common cell or origin, the subcolumnar reserve cell. The relative frequency with which the various types of carcinoma in situ are seen is in part explained by the ubiquitous nature of squamous metaplasia in the region of the transformation zone in women of reproductive age. It is suggested that squamous metaplasia is the soil on which most squamous carcinomas of the cervix evolve. The relatively low frequency with which adenocarcinoma and adenosquamous carcinoma in situ are encountered may also be dependent on their less accessible location in the endocervix.

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Endocervical and Cervical Neoplasms Adjacent to CarcinomaIn Situ

Cited by 13 publications

References 0 publications

Severe cervical glandular cell lesions with coexisting squamous cell lesions

Severe cervical glandular cell lesions with coexisting squamous cell lesions

The association between precancerous‐columnar and squamous lesions of the cervix: a morphometric study

Noninvasive precursor lesions of adenocarcinoma and mixed adenosquamous carcinoma of the cervix uteri

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