Endocapillary proliferative glomerulonephritis with crescent formation and concurrent tubulo-interstitial nephritis complicating retroperitoneal fibrosis with a high serum level of IgG4

Autoimmune Pancreatitis Associated with Various Extrapancreatic Lesions during a Long-term Clinical Course Successfully Treated with Azathioprine and Corticosteroid Maintenance Therapy

“…Renal biopsy reveals diffuse lymphoplasmacytic infiltration of the renal interstitium, and the lesions vary from diffuse tubulointerstitial nephritis to tumor-like masses according to the distribution patterns of the infiltrating cells (21). On the other hand, glomerulonephritis associated with AIP is rare (22,23). Katano et al (23) …”

Membranoproliferative Glomerulonephritis-Like Glomerular Disease and Concurrent Tubulointerstitial Nephritis Complicating IgG4-Related Autoimmune Pancreatitis

“…plicating IgG4-related disease is rare. Some cases with membranous nephropathy, with endocapillary proliferation, capillary wall thickening and crescent formation, or with tubulointerstitial nephritis have been reported (21,28,32 i g u r e 5 . I mmu n o f l u o r e s c e n c e s t a i n o f r e n a l t i s s u e s h o ws s t r o n g p o s i t i v e s t a i n i n g f o r C3 a n d I g G i n c o a r s e a n d g r a n u l a r me s a n g i a l a n d p e r i p h e r a l d e p o s i t s , a n d we a k s t a i n i n g f o r C1 q .…”

Possible IgG4-Related Kidney Disease Requiring a Differential Diagnosis of Membranous Lupus Nephritis

“…Glomerular changes were evident in a quarter of the reported cases of IgG4-related tubulointerstitial nephritis (2). Among them, membranous nephropathy was dominant (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). Membranous nephropathy, concomitant with IgG4-related tubulointerstitial nephritis, is considered linked to IgG4-related disease, but not a primary glomerular disease, because circulating anti-phospholipase A2 receptor antibodies, the most common autoantibodies in idiopathic membranous nephropathy (30), were undetected (11,12).…”

“…Hypocomplementemia and elevated antinuclear antibody (ANA) are frequently observed, whereas anti-SS-A, anti-SS-B, anti-Sm, anti-RNP and anti-double-stranded DNA (dsDNA) antibodies are generally negative (1). Occasionally, IgG 4-related tubulointerstitial nephritis accompanies glomerular diseases such as membranous nephropathy, mesangial proliferative glomerulonephritis and membranoproliferative glomerulonephritis; however, membranous nephropathy is dominant (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). We report a case, initially considered to be IgG4-related tubulointerstitial nephritis with membranous nephropathy requiring a differential diagnosis of membranous lupus nephritis (Class V) with severe tubulointerstitial changes.…”