Endocannabinoids and sleep

Prospéro-Garcı́a, Oscar; Pérez-Morales, Marcel; Méndez-Dı́az, Mónica; Contreras, Arceo

doi:10.1016/j.sleep.2013.11.091

Cited by 8 publications

(16 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several pathways act upon N‐acylphosphatidylethanolamine to produce ethanolamides (Figure , Figure S1, Table S2) . Ethanolamide with a longer unsaturated side chain (20:4), arachidonoyl ethanolamide (anandamide, AEA), is one of the most studied ethanolamides as it binds to the cannabinoid receptor . Palmitoyl‐ethanolamide (PEA) and stearoyl ethanolamide (SEA), structurally related to AEA, are devoid of affinity for cannabinoid receptors.…”

Section: Plasma Phospholipid Derivatives Blood Coagulation and Vtementioning

confidence: 99%

“…[60][61][62] Ethanolamide with a longer unsaturated side chain (20:4), arachidonoyl ethanolamide (anandamide, AEA), is one of the most studied ethanolamides as it binds to the cannabinoid receptor. 63 Palmitoyl-ethanolamide (PEA) and stearoyl ethanolamide (SEA), structurally related to AEA, are devoid of affinity for cannabinoid receptors. The role of PEA in inflammation and nociception via a variety of molecular mechanisms has been documented.…”

Section: Ethanolamides As Procoagulantsmentioning

confidence: 99%

See 1 more Smart Citation

Minor plasma lipids modulate clotting factor activities and may affect thrombosis risk

Deguchi

Elias

Griffin

2017

Research and Practice in Thrombosis and Haemostasis

View full text Add to dashboard Cite

Summary Different minor abundance plasma lipids significantly influence thrombin generation in vitro and significant differences in such lipids are linked to risk for venous thrombosis. Some plasma sphingolipids including glucosylceramide, lyso-sulfatide and sphingosine have anticoagulant properties whereas, conversely, some plasma phospholipid derivatives, including certain lyso-phospholipids and ethanolamides, have procoagulant properties. Plasma metabolite profiling of venous thrombosis patients showed association of venous thrombosis with decreased plasma long-chain acylcarntines, leading to discovery of their anticoagulant activity as inhibitors of factor Xa. Inhibition of factor Xa by acylcarnitines does not require the protein’s Gla-domain, emphasizing an expanded framework for the paradigm for lipid-clotting factor interactions. Overall, whether by genetics or environment, alterations in the dynamics of lipid metabolism linked to an altered lipidome may contribute to regulation of blood coagulation because imbalances between physiologic procoagulant and anticoagulant lipids may contribute to excessive thrombin generation that augments risk for thrombosis.

show abstract

Section: Plasma Phospholipid Derivatives Blood Coagulation and Vtementioning

confidence: 99%

Section: Ethanolamides As Procoagulantsmentioning

confidence: 99%

Minor plasma lipids modulate clotting factor activities and may affect thrombosis risk

Deguchi

Elias

Griffin

2017

Research and Practice in Thrombosis and Haemostasis

View full text Add to dashboard Cite

show abstract

“…The endocannabinoid signaling system is known to be involved in the modulation of diverse physiological processes and rhythms such as neural signaling, circannual rhythms, thermoregulation, appetite, and bone and energy metabolism and diseases such as cancer (Carey et al, 2003; Bellocchio et al, 2008a; Pagano et al, 2008; Maccarrone et al, 2015; Bogren et al, 2016; Prospero-Garcia et al, 2016; Korf, 2017). The endocannabinoid system influences regulation of bone remodeling through various avenues.…”

mentioning

confidence: 99%

“…Endocannabinoids are involved in the sleep cycle as well. 2-AG and AEA promote non-rapid-eye movement sleep and, through interaction with melanin-concentrating hormone neurons, also promote rapid-eye movement sleep (Prospero-Garcia et al, 2016). Alternatively, OEA and PEA promote wakefulness (Prospero-Garcia et al, 2016).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Seasonal Changes in Endocannabinoid Concentrations between Active and Hibernating Marmots (Marmota flaviventris)

et al. 2018

View full text Add to dashboard Cite

Hibernation is a naturally occurring model for studying diseases such as obesity and osteoporosis. Hibernators, marmots (Marmota flaviventris) among them, are able to nearly double their body mass by increasing fat stores prior to hibernation without the negative consequences of obesity. They are also physically inactive for extended periods of time without experiencing negative effects on the skeleton. The endocannabinoid system is involved in modulating neural signaling, circannual rhythms, behavior, appetite, thermogenesis, and bone and energy metabolism. These systems are also altered to maintain homeostasis during hibernation. This study aims to better understand the involvement of the endocannabinoid system in the regulation of physiological processes during hibernation by quantifying the seasonal variation of endocannabinoids and endocannabinoid-like ligands in both active and hibernating marmots. We hypothesized that there would be significant changes in endocannabinoid concentrations at the tissue level in marmots between active and hibernating states. Concentrations were measured in brain, serum, brown adipose tissue, white adipose tissue, bone marrow, cortical bone, and trabecular bone using microflow chromatography coupled with tandem quadrupole mass spectrometry. Significant changes were found, such as a 30-fold decrease in 2-arachidonoyl glycerol (2-AG) in cortical bone during hibernation. Many endocannabinoid and endocannabinoid-like ligands decreased in brown adipose tissue, white adipose tissue, and cortical bone, while several ligands increased in bone marrow. This result supports our hypothesis and suggests the possibility of a peripherally controlled shift in energy metabolism, reduction in bone metabolism, and suppression of the immune system during hibernation.

show abstract

Are Sweet Dreams Made of These? Understanding the Relationship Between Sleep and Cannabis Use

Edwards

Filbey

2021

Cannabis and Cannabinoid Research

View full text Add to dashboard Cite

Introduction: There is widespread literature on the interaction between cannabis use and sleep, yet the mechanisms that underlie this relationship are not well understood. Several factors lead to inconsistencies in this relationship suggesting a nuanced interaction between cannabis and sleep. An important question that remains to be addressed is the temporal relationship between disrupted sleep and cannabis use. This literature review summarizes the existing literature on the association between disrupted sleep and cannabis toward the goal of addressing the question of the chronology of these reported effects. Materials and Methods: We conducted a review of the literature using PubMed to summarize current knowledge on the association between cannabis use and sleep in humans. Results: We identified 31 studies on the association of cannabis use and sleep. The findings from these studies were mixed. Cannabis was associated with a variety of impacts on sleep ranging from beneficial effects, such as reduced sleep-onset latency, to negative outcomes, such as reduced sleep duration and suppressed rapid eye movement oscillations. The chronology of the interaction of cannabis and sleep was unclear, although much of the current literature focus on factors that modulate how cannabis impairs sleep after initial use. Conclusion:There was sufficient evidence to suggest that cannabis use alters circadian rhythms, and hence, negatively impacts sleep. The current literature is largely from studies utilizing self-report measures of sleep; thus, objective measures of sleep are needed. In addition, although there were no empirical studies on the temporal relationship between cannabis use and sleep, the majority of the literature focused on characterizing sleep impairment after cannabis use.

show abstract

Endocannabinoids and sleep

Cited by 8 publications

References 0 publications

Minor plasma lipids modulate clotting factor activities and may affect thrombosis risk

Minor plasma lipids modulate clotting factor activities and may affect thrombosis risk

Seasonal Changes in Endocannabinoid Concentrations between Active and Hibernating Marmots (Marmota flaviventris)

Are Sweet Dreams Made of These? Understanding the Relationship Between Sleep and Cannabis Use

Contact Info

Product

Resources

About