Endocannabinoid System and Cannabinoid 1 Receptors in Patients With Pharmacoresistant Temporal Lobe Epilepsy and Comorbid Mood Disorders

Rocha, Luisa; Çınar, Reşat; Guevara‐Guzmán, Rosalinda; Alonso-Vanegas, Mario; San-Juan, Daniel; Martínez‐Juárez, Iris E.; Castañeda‐Cabral, José Luis; Carmona-Cruz, Francia

doi:10.3389/fnbeh.2020.00052

Cited by 26 publications

(23 citation statements)

References 65 publications

(72 reference statements)

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“…Our results of increased CB1R expression in limbic brain regions are in agreement with other animal models and humans with TLE (Wallace et al, 2003;Falenski et al, 2007;Maglóczky et al, 2010;Karlócai et al, 2011;Rocha et al, 2020). We observed increased endogenous CB1R expression in WARs in comparison to Wistar rats in the iMO of the hippocampus.…”

Section: Discussionsupporting

confidence: 92%

“…Generally, CB1R regulate glutamatergic and GABAergic neurotransmission in presynaptic terminals (Katona et al, 2001;Hill et al, 2007;Turu and Hunyady, 2010), although postsynaptic CB1R modulation was also detected in the brain (Busquets-Garcia et al, 2018). CB1R are associated with epilepsies and several epilepsy-related comorbidities, such as anxiety, depression, and autism (Bhattacharyya et al, 2017;Hosie et al, 2018;Rocha et al, 2020). Additionally, changes in CB1R expression were observed in limbic brain sites after limbic seizures in animal models and humans with epilepsies (Wallace et al, 2003;Falenski et al, 2009;Maglóczky et al, 2010;Rocha et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

“…CB1R are associated with epilepsies and several epilepsy-related comorbidities, such as anxiety, depression, and autism (Bhattacharyya et al, 2017;Hosie et al, 2018;Rocha et al, 2020). Additionally, changes in CB1R expression were observed in limbic brain sites after limbic seizures in animal models and humans with epilepsies (Wallace et al, 2003;Falenski et al, 2009;Maglóczky et al, 2010;Rocha et al, 2020). However, the effects of acute (brainstem) and chronic (limbic) audiogenic seizures on CB1R expression are unknown.…”

Section: Introductionmentioning

confidence: 99%

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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“…Generally, CB1R regulate glutamatergic and GABAergic neurotransmission in presynaptic terminals (Katona et al, 2001 ; Hill et al, 2007 ; Turu and Hunyady, 2010 ), although postsynaptic CB1R modulation was also detected in the brain (Busquets-Garcia et al, 2018 ). CB1R are associated with epilepsies and several epilepsy-related comorbidities, such as anxiety, depression, and autism (Bhattacharyya et al, 2017 ; Hosie et al, 2018 ; Rocha et al, 2020 ). Additionally, changes in CB1R expression were observed in limbic brain sites after limbic seizures in animal models and humans with epilepsies (Wallace et al, 2003 ; Falenski et al, 2009 ; Maglóczky et al, 2010 ; Rocha et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

“…CB1R are associated with epilepsies and several epilepsy-related comorbidities, such as anxiety, depression, and autism (Bhattacharyya et al, 2017 ; Hosie et al, 2018 ; Rocha et al, 2020 ). Additionally, changes in CB1R expression were observed in limbic brain sites after limbic seizures in animal models and humans with epilepsies (Wallace et al, 2003 ; Falenski et al, 2009 ; Maglóczky et al, 2010 ; Rocha et al, 2020 ). However, the effects of acute (brainstem) and chronic (limbic) audiogenic seizures on CB1R expression are unknown.…”

Section: Introductionmentioning

confidence: 99%

Cannabinoid Receptor Type 1 (CB1R) Expression in Limbic Brain Structures After Acute and Chronic Seizures in a Genetic Model of Epilepsy

Lazarini-Lopes

Silva-Júnior

Servilha-Menezes

et al. 2020

Front. Behav. Neurosci.

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The endocannabinoid system (ECS) is related to several physiological processes, associated to the modulation of brain excitability, with impact in the expression of susceptibility and control of epileptic seizures. The cannabinoid receptor type 1 (CB1R) is widely expressed in the brain, especially in forebrain limbic structures. Changes in CB1R expression are associated with epileptic seizures in animal models and humans. The Wistar Audiogenic Rat (WAR) strain is a genetic model of epilepsy capable of mimicking tonic-clonic and limbic seizures in response to intense sound stimulation. The WAR strain presents several behavioral and physiological alterations associated with seizure susceptibility, but the ECS has never been explored in this strain. Therefore, the aim of the present study was to characterize CB1R expression in forebrain limbic structures important to limbic seizure expression in WARs. We used a detailed anatomical analysis to assess the effects of acute and chronic audiogenic seizures on CB1R expression in several layers and regions of hippocampus and amygdala. WARs showed increased CB1R immunostaining in the inner molecular layer of the hippocampus, when compared to control Wistar rats. Acute and chronic audiogenic seizures increased CB1R immunostaining in several regions of the dorsal hippocampus and amygdala of WARs. Also, changes in CB1R expression in the amygdala, but not in the hippocampus, were associated with limbic recruitment and limbic seizure severity in WARs. Our results suggest that endogenous alterations in CB1R immunostaining in WARs could be associated with genetic susceptibility to audiogenic seizures. We also demonstrated CB1R neuroplastic changes associated with acute and chronic seizures in the amygdala and hippocampus. Moreover, the present study brings important information regarding CB1R and seizure susceptibility in a genetic model of seizures and supports the relationship between ECS and epilepsy.

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