Endocannabinoid regulation of inward rectifier potassium (Kir) channels
Sultan Mayar,
Mariia Borbuliak,
Andreas Zoumpoulakis
et al.
Abstract:The inward rectifier potassium channel Kir2.1 (KCNJ2) is an important regulator of resting membrane potential in both excitable and non-excitable cells. The functions of Kir2.1 channels are dependent on their lipid environment, including the availability of PI(4,5)P2, secondary anionic lipids, cholesterol and long-chain fatty acids acyl coenzyme A (LC-CoA). Endocannabinoids are a class of lipids that are naturally expressed in a variety of cells, including cardiac, neuronal, and immune cells. While these lipid… Show more
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