Endocannabinoid 2-arachidonoylglycerol protects inflammatory insults from sulfur dioxide inhalation via cannabinoid receptors in the brain

Li, Ben; Chen, Minjun; Guo, Lin; Yang, Yun; Li, Guangke; Sang, Nan

doi:10.1016/j.jes.2016.05.031

Cited by 13 publications

(5 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies have highlighted the regulatory effects of the ECS on neuroinflammatory conditions by modulating the production of cytokines. For instance, 2-AG was shown to prevent the overexpression of TNF-α, IL-1β, and iNOS in a murine model of SO 2 -induced brain inflammation [ 172 ]. MAGL-deficiency leading to increased 2-AG levels also reduced brain PGE 2 and pro-inflammatory cytokine levels following peripheral LPS administration in mice [ 173 ].…”

Section: Neuroinflammation-induced Synaptopathy and Neurodegenerative Diseasesmentioning

confidence: 99%

Neuroprotective and Immunomodulatory Action of the Endocannabinoid System under Neuroinflammation

Kasatkina

Rittchen

Sturm

2021

IJMS

View full text Add to dashboard Cite

Endocannabinoids (eCBs) are lipid-based retrograde messengers with a relatively short half-life that are produced endogenously and, upon binding to the primary cannabinoid receptors CB1/2, mediate multiple mechanisms of intercellular communication within the body. Endocannabinoid signaling is implicated in brain development, memory formation, learning, mood, anxiety, depression, feeding behavior, analgesia, and drug addiction. It is now recognized that the endocannabinoid system mediates not only neuronal communications but also governs the crosstalk between neurons, glia, and immune cells, and thus represents an important player within the neuroimmune interface. Generation of primary endocannabinoids is accompanied by the production of their congeners, the N-acylethanolamines (NAEs), which together with N-acylneurotransmitters, lipoamino acids and primary fatty acid amides comprise expanded endocannabinoid/endovanilloid signaling systems. Most of these compounds do not bind CB1/2, but signal via several other pathways involving the transient receptor potential cation channel subfamily V member 1 (TRPV1), peroxisome proliferator-activated receptor (PPAR)-α and non-cannabinoid G-protein coupled receptors (GPRs) to mediate anti-inflammatory, immunomodulatory and neuroprotective activities. In vivo generation of the cannabinoid compounds is triggered by physiological and pathological stimuli and, specifically in the brain, mediates fine regulation of synaptic strength, neuroprotection, and resolution of neuroinflammation. Here, we review the role of the endocannabinoid system in intrinsic neuroprotective mechanisms and its therapeutic potential for the treatment of neuroinflammation and associated synaptopathy.

show abstract

Section: Neuroinflammation-induced Synaptopathy and Neurodegenerative Diseasesmentioning

confidence: 99%

Neuroprotective and Immunomodulatory Action of the Endocannabinoid System under Neuroinflammation

Kasatkina

Rittchen

Sturm

2021

IJMS

View full text Add to dashboard Cite

show abstract

“…However, 2-AG play an important role in inflammation. 2-AG attenuates the stimulation of the organism by proinflammatory factors, such as TNF-α ( Chanda et al, 2017 ) and IL-1β ( Li, et al, 2017 ). Our study found that APEC infection decreased the secretion of 2-AG in the lung tissues.…”

Section: Discussionmentioning

confidence: 99%

Paeoniflorin protects chicken against APEC-induced acute lung injury by affecting the endocannabinoid system and inhibiting the PI3K/AKT and NF-κB signaling pathways

Shen,

Fu,

Deng

et al. 2024

Poultry Science

View full text Add to dashboard Cite

“…eCB is present and is active in the human body, even if one has not ingested cannabis. Endogenous 2-arachidonylglycerol (2-AG), one of the main eCBs, contributes to the restoration of inflammation-related microvasculature dysfunction caused by overoxidation [ 33 ]. Endogenous 2-AG abolished VCAM-1 and ICAM-1 elevation induced by CB1/2 receptor activation [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

“…Endogenous 2-arachidonylglycerol (2-AG), one of the main eCBs, contributes to the restoration of inflammation-related microvasculature dysfunction caused by overoxidation [ 33 ]. Endogenous 2-AG abolished VCAM-1 and ICAM-1 elevation induced by CB1/2 receptor activation [ 33 ]. The pleiotropic effects of endogenous 2-AG may prevent and treat depression by abolishing inflammation and vasculature dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Omega-3 Eicosapentaenoic Acid Is Related to Happiness and a Sense of Fulfillment—A Study among Female Nursing Workers

et al. 2020

View full text Add to dashboard Cite

Background: Omega (ω) 3 fatty acid (FA) is a polyunsaturated FA (PUFA) that can modulate some mental statuses. However, most studies have not considered the functional differences between eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). We investigated associations among happiness, a sense of fulfillment and serum ω3 PUFA levels. Methods: Participants were 133 female staff from a hospital and nursing homes. Happiness was measured using the Japanese version of the subjective happiness scale (SHS); a sense of fulfillment was assessed using a visual analogue scale. Serum FA concentrations were measured. A partial correlation test and a regression model were applied. Results: The SHS scores showed significantly positive correlations with a sense of fulfillment, DHA% and EPA% (p < 0.05, < 0.05 and < 0.005, respectively), after controlling for age, BMI, menopause, snacking habits and leisure-time physical activities. A sense of fulfillment was significantly negatively correlated with α-linoleic acid%, and positively correlated with DHA% and EPA% (p < 0.05, < 0.05 and < 0.005, respectively), after controlling for the confounders. A regression model showed that a sense of fulfillment, EPA, and not stopping menstruation explained happiness (standardised beta, B = 0.18, p < 0.05; B = 0.24, p < 0.01; and B = 0.32, and p < 0.05, respectively), whereas age, BMI and snacking habits could not. Simultaneously, a regression model could not explain the association between DHA and happiness. Conclusion: Happiness was related with serum EPA%, a sense of fulfillment, and premenopause.

show abstract

Endocannabinoid 2-arachidonoylglycerol protects inflammatory insults from sulfur dioxide inhalation via cannabinoid receptors in the brain

Cited by 13 publications

References 50 publications

Neuroprotective and Immunomodulatory Action of the Endocannabinoid System under Neuroinflammation

Neuroprotective and Immunomodulatory Action of the Endocannabinoid System under Neuroinflammation

Paeoniflorin protects chicken against APEC-induced acute lung injury by affecting the endocannabinoid system and inhibiting the PI3K/AKT and NF-κB signaling pathways

Omega-3 Eicosapentaenoic Acid Is Related to Happiness and a Sense of Fulfillment—A Study among Female Nursing Workers

Contact Info

Product

Resources

About