Endocan is useful biomarker of survival and severity in sepsis

Mihajlović, D; Lendak, Dajana; Brkić, Snežana; Drašković, Biljana; Mitić, Gorana; Mikic, Aleksandra S. Novakov; Ćebović, Tatjana

doi:10.1016/j.mvr.2014.04.004

Cited by 78 publications

(64 citation statements)

References 30 publications

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“…In accordance with the presented results, Guzman et al previously demonstrated that lactate had an AUC of 0.72 and PCT 0.64 for mortality prediction based on values on admission (38). Similar result was also observed by Mihajlovic et al (39). Due to the crucial role of endothelial cells in the pathogenesis of MODS and sepsis (22)(23)(24), the value of TJassociated proteins for predicting in-hospital mortality in sepsis was also analyzed.…”

Section: Discussionsupporting

confidence: 88%

Prognostic Value of Plasma Tight-Junction Proteins for Sepsis in Emergency Department

Zhao

Dong

Zhao

et al. 2016

Shock

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Section: Discussionsupporting

confidence: 88%

Prognostic Value of Plasma Tight-Junction Proteins for Sepsis in Emergency Department

Zhao

Dong

Zhao

et al. 2016

Shock

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“…Changes that occur in the microvasculature, mainly affecting endothelial cells, are probably involved in the pathophysiology of multiorgan dysfunction (MODS) in sepsis. Mihajlovic et al [43]. reported that in 60 patients with sepsis-induced organ failure endocan levels were higher in nonsurvivors.…”

Section: Other Inflammatory Diseases and Endocanmentioning

confidence: 99%

Endocan: A novel inflammatory indicator in cardiovascular disease?

et al. 2015

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“…Furthermore, significantly higher Endocan values can be detected in non-survivors at admission to ICU [137] . In addition, a recent study by Mihajlovic et al [138] determined a correlation between initially elevated Endocan levels and the development of sepsis induced organ failure over time [139] . Accordingly, in patients with ARDS, Endocan levels seem useful to predict mortality and multiple-organ dysfunction.…”

Section: Endocanmentioning

confidence: 99%

Are there new approaches for diagnosis, therapy guidance and outcome prediction of sepsis?

Kojic

Siegler

Uhle

et al. 2015

WJEM

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Beside many efforts to improve outcome, sepsis is still one of the most frequent causes of death in critically ill patients. It is the most common condition with high mortality in intensive care units. The complexity of the septic syndrome comprises immunological aspects -i.e. , sepsis induced immunosuppression -but is not restricted to this fact in modern concepts. So far, exact mechanisms and variables determining outcome and mortality stay unclear. Since there is no typical risk profile, early diagnosis and risk stratification remain difficult, which hinders rapid and effective treatment initiation. Due to the heterogeneous nature of sepsis, potential therapy options should be adapted to the individual. Biomarkers like C-reactive protein and procalcitonin are routinely used as complementary tools in clinical decision-making. Beyond the acute phase proteins, a wide bunch of promising substances and non-laboratory tools with potential diagnostic and prognostic value is under intensive investigation. So far, clinical decision just based on biomarker assessment is not yet feasible. However, biomarkers should be considered as a complementary approach. Core tip: Sepsis is a complex continuum of disturbed systems. Despite the presence of clinical consensus criteria, the early diagnosis especially in the perioperative setting is challenging. A magnitude of potential new biomarkers is tested for this purpose, but evidence is mounting that due to the complex nature of the syndrome, biomarkers are rather complementary tools for clinical decision making than "magic bullets". Moreover, biomarkers are also evaluated for therapy guidance, linking diagnostic results to an individual therapeutic regime. This review summarizes the developments in the biomarker field, aiming to provide an overview about current targets and their limitations.

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Endocan is useful biomarker of survival and severity in sepsis

Cited by 78 publications

References 30 publications

Prognostic Value of Plasma Tight-Junction Proteins for Sepsis in Emergency Department

Prognostic Value of Plasma Tight-Junction Proteins for Sepsis in Emergency Department

Endocan: A novel inflammatory indicator in cardiovascular disease?

Are there new approaches for diagnosis, therapy guidance and outcome prediction of sepsis?

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