Endocan and Soluble Triggering Receptor Expressed on Myeloid Cells-1 as Novel Markers for Neonatal Sepsis

Saldır, Mehmet; Tunç, Turan; Çekmez, Ferhat; Çetınkaya, Merih; Kalaycı, Tuğçe Özlem; Fidanci, Kursat; Babacan, Oguzhan; Erdem, Galip; Koçak, Necmettin; Sarı, Erkan; Akgül, Emin Özgür; Kul, Mustafa

doi:10.1016/j.pedneo.2015.03.006

Cited by 37 publications

(43 citation statements)

References 24 publications

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“…In our study, we found that sTREM-1 levels showed highly significant statistical decrease 48-72 hrs after administration of antibiotics in relation to initial sTREM-1 levels indicating that sTREM-1 is a useful monitoring marker for follow-up of septic neonates to observe the effect of treatment which is consistent with the results of Sarafidis et al (2010) and Saldir et al (2015). The main limitation in our study was small sized sample number which can be validated by further large scale studies before application to general population.…”

supporting

confidence: 86%

“…Although several studies documented the role of serum level of sTREM-1 in diagnosis of neonatal sepsis (Su et al, 2012;Saldir et al, 2015), there is insufficient data regarding its prognostic value in neonatal sepsis. Hence, our study aimed at investigating the role of serum levels of sTREM-1 in early diagnosis and prognosis of LOS.…”

Section: Int J Adv Res 4(8) 123-131 124mentioning

confidence: 99%

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SOLUBLE TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS -1 (sTREM-1) AS aDIAGNOSTIC AND PROGNOSTIC MARKER FOR LATE-ONSET SEPSIS IN PRETERM NEONATES.

El-khier¹,

Nassar²,

AbdElAal³

et al. 2016

IJAR

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supporting

confidence: 86%

Section: Int J Adv Res 4(8) 123-131 124mentioning

confidence: 99%

SOLUBLE TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS -1 (sTREM-1) AS aDIAGNOSTIC AND PROGNOSTIC MARKER FOR LATE-ONSET SEPSIS IN PRETERM NEONATES.

El-khier¹,

Nassar²,

AbdElAal³

et al. 2016

IJAR

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“…PCT serum levels rise faster than CRP, but the initial reports of sensitivity close to 100% have not been confirmed by subsequent evaluations [15,19,20]. The complex pathophysiological mechanisms of sepsis involve inflammation and endothelial activation as critical determinants of the host response, leading to the hypothesis that biomarkers of endothelium dysfunction might be used as clinical tools in the diagnosis and follow-up of sepsis [21].…”

Section: Discussionmentioning

confidence: 99%

Endocan serum concentration in uninfected newborn infants

Zonda

Zonda²,

Cernomaz

et al. 2019

J Infect Dev Ctries

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Introduction: Endocan is a specific endothelial mediator involved in the inflammatory response. Its role in the diagnosis of sepsis has been studied in adult patients and late onset neonatal sepsis. The clinical signs of early onset sepsis (EOS) are nonspecific and routinely used biomarkers, such as C-reactive protein and procalcitonin, have low sensitivity, specificity and positive predictive value. Endocan could be useful as a biomarker for diagnosis of EOS, but at present normal range values for this molecule have not been reported. The aim of this study is to establish the normal values range for serum endocan in term and preterm newborns without risk factors for EOS and to characterize the variation pattern of its levels at different postnatal moments. Methodology: Mean endocan serum concentration (ESC) was measured in term and preterm newborns without clinical suspicion of EOS at different moments from birth. Results: ESC (ng/mL) in term newborns was 1.74+/-0.13 on day 1 and 2.02+/-0.41 on day 3 respectively, (p=0.09). In preterm newborns ESC (ng/mL) was 2.02+/-0.11 and 1.97+/-0.18, (p=0.8) for day 1 and 3 respectively. ESC was not significantly influenced by sex, mode of delivery, evidence of fetal distress or presence of minor birth trauma. Conclusions: ESC (ng/mL) between the first and third day of life in either term or preterm infants don’t appear to be significantly influenced by factors that are associated with elevation of inflammatory markers, thus using this biomarker for the diagnosis of EOS might reduce the false positive results.

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“…sTREM-1 is under investigation as a biomarker in a variety of infectious and non-infectious inflammatory conditions and is detected in the bronchoalveolar lavage (BAL) fluid in pneumonia 7 and in the serum 8,9 and urine 10 of septic patients. It is a marker of neonatal sepsis 11 and predicts shock and death. 12 sTREM-1 and its gene polymorphisms are also associated with sepsis prognosis 13 and high sTREM-1 is predictive of Systemic Inflammatory Response Syndrome (SIRS) 14 after surgery.…”

Section: Introductionmentioning

confidence: 99%

Reversal of TREM-1 ectodomain shedding and improved bacterial clearance by intranasal metalloproteinase inhibitors

et al. 2017

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Triggering receptor expressed on myeloid cells-1 (TREM-1) is expressed on neutrophils and monocyte/macrophages and amplifies Toll-like receptor-mediated inflammation during infection. TREM-1 also exists in an antagonistic soluble form (sTREM-1) that has been used as a peripheral biomarker in sepsis, though the mechanisms of its release are not entirely clear. The requirement of TREM-1 in single microbial infections is controversial, with some studies showing a protective role and others a contribution to immunopathology. Furthermore, the role of membrane-bound and sTREM-1 in polygenic infections is currently unknown. In a mouse co-infection model where preceding viral infection greatly enhances bacteria co-infection, we now determine a mechanisms for the striking increase in sTREM-1 and the loss of TREM-1 on surface of neutrophils. We identified a matrix metalloproteinase (MMP)-9 cleavage site in TREM-1 and that the increase of MMP-9 in bronchoalveolar lavage fluid mirrors sTREM-1 release. In vitro studies with neutrophils and MMP-9 and the reduction of sTREM-1 in vivo after MMP-9 inhibition verifies that this enzyme cleaves TREM-1. Intriguingly, MMP-9 inhibition significantly reduces bacterial load and ensuing immunopathology in a co-infection model. This highlights MMP-9 inhibition as a potential therapeutic via blocking cleavage of TREM-1.

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Endocan and Soluble Triggering Receptor Expressed on Myeloid Cells-1 as Novel Markers for Neonatal Sepsis

Abstract: Serum sTREM-1, IL-6, endocan levels, and I/T ratio increased in septic neonates. However, the diagnostic accuracy of circulating sTREM-1 seemed to be better than endocan and I/T ratio, but lower than IL-6.

Cited by 37 publications

References 24 publications

SOLUBLE TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS -1 (sTREM-1) AS aDIAGNOSTIC AND PROGNOSTIC MARKER FOR LATE-ONSET SEPSIS IN PRETERM NEONATES.

SOLUBLE TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS -1 (sTREM-1) AS aDIAGNOSTIC AND PROGNOSTIC MARKER FOR LATE-ONSET SEPSIS IN PRETERM NEONATES.

Endocan serum concentration in uninfected newborn infants

Reversal of TREM-1 ectodomain shedding and improved bacterial clearance by intranasal metalloproteinase inhibitors

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