Endobronchial ultrasound in hilar and conventional TBNA-negative/inconclusive mediastinal lymphadenopathy

Chhajed, Prashant N.; Odermatt, Rahel; Garnier, Christophe von; Chaudhari, Parag; Leuppi, Joerg D.; Stolz, Daiana; Tamm, Michael

doi:10.4103/0973-1482.82930

Cited by 12 publications

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“…Initially, the EBUS‐TBNA was introduced mainly for lung cancer staging but is now used as a standard of care for diagnosis of mediastinal and hilar lymphadenopathy from various causes . The role of EBUS‐TBNA is also described in conventional TBNA‐negative patients . The vast literature in the last decade supports it as a minimally invasive and a safe procedure.…”

Section: Discussionmentioning

confidence: 99%

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Endobronchial ultrasound‐guided transbronchial needle aspiration: Safe as it sounds

et al. 2017

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Real-time endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has earned its place as a standard of care in the evaluation of mediastinal and hilar lymphadenopathy. It is a minimally invasive and a safe procedure with high diagnostic accuracy and efficacy. The increased usage of EBUS-TBNA worldwide has thrown light on its possible complications including death. The complications range from minor to life threatening in few and may occur either early or later in the course after the procedure. The present review summarizes the reported complications from EBUS-TBNA, their outcome and the modalities used for their management.

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Section: Discussionmentioning

confidence: 99%

“…2 The role of EBUS-TBNA is also described in conventional TBNA-negative patients. 42 The vast literature in the last decade supports it as a minimally invasive and a safe procedure. As the procedure gains worldwide popularity, its complications are also being recognized (Tables 3-6).…”

Section: Discussionmentioning

confidence: 99%

Endobronchial ultrasound‐guided transbronchial needle aspiration: Safe as it sounds

et al. 2017

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“…The sensitivity, negative predictive value for malignancy, and overall accuracy for EBUS-TBNA were 87%, 73%, and 88%, respectively (13). In another study, Chhajed et al determined that EBUS-TBNA has a good diagnostic yield on conventional TBNA negative mediastinal-hilar lymphadenopathy (14). At an average of 5%-8%, false negative results have been achieved in bronchoalveolar carcinoma, carcinoids, in some tumors with high mucin levels but low metabolic activity, lesions smaller than 10 mm, and hyperglycemic patients (12).…”

Section: Discussionmentioning

confidence: 99%

The evaluation of hypermetabolic mediastinal–hilar lymph nodes determined byPET/CT in pulmonary and extrapulmonary malignancies: correlation with EBUS-TBNA

KANDEMİR¹,

ŞENTÜRK²,

Özdemir³

et al. 2015

Turk J Med Sci

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Background/aim: We aimed to define the optimal SUVmax cut-off value in determination of mediastinal-hilar lymph node metastasis, by comparing positive PET/CT results with the results of endobronchial ultrasound guided transbronchial needle aspiration biopsy (EBUS-TBNA).Materials and methods: Thirty-one patients with malignancy whose PET/CT imaging revealed a hypermetabolic mediastinal and/ or hilar lymph node and who had undergone EBUS-TBNA were evaluated retrospectively. Histopathology was regarded as the gold standard. The diagnostic role of PET/CT in mediastinal/hilar lymph node metastasis was investigated and compared with the results of contrast-enhanced CT.Results: When a SUVmax value of 2.5 was used, the sensitivity, positive predictive value (PPV), and diagnostic accuracy of the PET/CT were 100%, 65.4%, and 65.4% respectively. In the ROC analysis, the SUVmax cut-off value with the highest diagnostic accuracy (75%) was calculated as 6.3, and when this value was considered, the sensitivity, specificity, PPV, negative predictive value, and diagnostic accuracy of the PET/CT were determined as 70.6%, 83.3%, 88.9%, 60%, and 75% respectively (AUC: 0.779). The sensitivity, PPV, and diagnostic accuracy of the thorax CT were calculated as 91.1%, 72%, and 71.1%, respectively. Conclusion:When determining mediastinal-hilar lymph node metastasis via PET/CT, although a SUVmax cut-off value of 6.3 increases specificity and diagnostic accuracy, we think that a SUVmax cut-off value of 2.5 and above give more optimal results in routine practice.

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“…EBUS TBNA has also been shown to have a good diagnostic yield in hilar lymphadenopathy and in conventional TBNA-negative mediastinal lymphadenopathy. [2] A recent study in the Journal reported that EBUS-TBNA is a sensitive, specific, minimally invasive, and safe procedure for the diagnosis of mediastinal and hilar metastases from extrapulmonary malignancy in a TB-endemic country. [3] In 40 patients with proven or suspected metastasis of unknown origin, the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of EBUS-TBNA, based on the number of patients, were 90.0, 100, 100, 90.9, and 95.0%, respectively.…”

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confidence: 99%

Endobronchial ultrasound-guided transbronchial needle aspiration: The standard of care for evaluation of mediastinal and hilar lymphadenopathy

2013

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Endobronchial ultrasound in hilar and conventional TBNA-negative/inconclusive mediastinal lymphadenopathy

Abstract: EBUS TBNA has a good diagnostic yield in hilar lymphadenopathy and in conventional TBNA-negative mediastinal lymphadenopathy.

Cited by 12 publications

References 0 publications

Endobronchial ultrasound‐guided transbronchial needle aspiration: Safe as it sounds

Endobronchial ultrasound‐guided transbronchial needle aspiration: Safe as it sounds

The evaluation of hypermetabolic mediastinal–hilar lymph nodes determined byPET/CT in pulmonary and extrapulmonary malignancies: correlation with EBUS-TBNA

Endobronchial ultrasound-guided transbronchial needle aspiration: The standard of care for evaluation of mediastinal and hilar lymphadenopathy

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