Endobronchial Ultrasound–Guided Transbronchial Needle Injection for Local Control of Recurrent Non–Small Cell Lung Cancer

Khan, Fatima; Anker, Christopher J.; Garrison, Garth; Kinsey, C. Matthew

doi:10.1513/annalsats.201408-358bc

Cited by 38 publications

(32 citation statements)

References 9 publications

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“…The goal of EBUS-TBNI for intratumoral therapy in the prior report is to achieve local control of recurrent lung cancer. [15] In this case, the use of EBUS-TBNI in this patient is committed to relieving the symptom of dyspnea and opening up the opportunity for systemic treatments. The tumor treated with combination of local interventions and systemic chemotherapy had a good response, 50% reduction of tumor.…”

Section: Discussionmentioning

confidence: 99%

A case report of local treatment of inoperable squamous cell lung carcinoma with convex-probe endobronchial ultrasound-guided intratumoral injection of cisplatin in a patient with severe COPD

Liu

Rao

et al. 2017

Medicine

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Rationale:Endobronchial ultrasound as a powerful diagnostic technology can also be used to perform intratumoral chemotherapy for extraluminal tumor.Patient concerns:A 69-year-old man with chronic obstructive pulmonary disease (COPD) presented with worsening dyspnea. A pulmonary function test showed severe airway obstruction and that forced expiratory volume in 1 s was 43% of the predicted value after a bronchodilator.Diagnoses:A bronchoscopy and histopathological analyses revealed a squamous cell carcinoma mostly located outside of the lumen with central airway obstruction.Interventions:Due to the poor pulmonary function, he cannot tolerate conventional active treatments, such as surgery, full dose systemic chemotherapy, or radiotherapy. Local treatments including argon plasma coagulation, cryotherapy, and bronchoscopic endobronchial intratumoral chemotherapy with cisplatin were performed to debulk intraluminal component of the tumor and recanalize occlusive airways in the left upper lobe. Convex-probe endobronchial ultrasound-guided transbronchial needle injection (EBUS-TBNI) delivered cisplatin into the extraluminal component of the tumor to relieve the symptom of dyspnea and opened up the opportunity for systemic chemotherapy without severe systemic complications.Outcomes:The patient had a good response to the comprehensive therapy of 4 cycles of low-dose intravenous chemotherapy and bronchoscopic interventions.Lessons:EBUS-TBNI is proven an effective and safe method to treat inoperable extraluminal central pulmonary carcinoma complicated with severe COPD. In the future, EBUS-TBNI may offer more treatment indications outlined in the existing publications.

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Section: Discussionmentioning

confidence: 99%

A case report of local treatment of inoperable squamous cell lung carcinoma with convex-probe endobronchial ultrasound-guided intratumoral injection of cisplatin in a patient with severe COPD

Liu

Rao

et al. 2017

Medicine

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“…If these parameters are carefully combined then the drug formulation will be distributed homogenously within the tumor and the treatment will be effective. [26,27] Figure 1. …”

Section: Endobronchial Ultrasound (Ebus) As a Tool For Local Treatmentmentioning

confidence: 99%

Endobronchial Ultrasound (EBUS) for Local Drug Application: Future Methodology

Sardeli¹,

Bai²,

Freitag³

et al. 2017

Oncomedicine

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Lung cancer is the leading cause of cancer death among cancer patients with a higher rate for man, but soon also for women. New targeted treatments are already being used with the current addition of immunotherapy. However, for many patients there are several adverse effects or issues that emerge during therapy and there are cases where we would like to have local treatment options such as; in the case of microwave ablation, radiofrequency laser, argon plasma and cryotherapy. Endobronchial ultrasound system (linear) could be used and it has been used for local drug delivery into thoracic lymph nodes and lung cancer tumors.

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“…This procedure is widely used for evaluation and diagnosis of mediastinal abnormalities such as lymphoma, sarcoidosis, vascular abnormalities and other tumors (2)(3)(4). Recently, the therapeutic role of EBUS is cautiously emerging with few reports of its use in placing fiducial markers for central pulmonary nodules to guide stereotactic body radiation (5,6) and for local injection of chemotherapeutic agents to treat lung cancer (7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Endobronchial ultrasound—guidance for interstitial photodynamic therapy of locally advanced lung cancer—a new interventional concept

Harris¹,

Oakley²,

Bellnier³

et al. 2017

J. Thorac. Dis.

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Recent advances in interventional pulmonology led to a significant expansion of the diagnostic and therapeutic role of endobronchial ultrasound. In this paper, we describe a new concept for using endobronchial ultrasound to guide interstitial photodynamic therapy (PDT). For this purpose, we conducted in vitro and in vivo experiments using a phantom and animal models, respectively. A new 0.5 mm optical fiber, with cylindrical diffuser end, was used to deliver the therapeutic light through the 21-gauge endobronchial ultrasound needle. The animal experiments were performed under real-time ultrasonography guidance in mice and rabbits' tumor models. Safe and effective fiber placements and tumor illumination was accomplished. In addition, computer simulation of light propagation suggests that locally advanced lung cancer tumor can be illuminated. This study demonstrates the potential feasibility of this new therapeutic modality approach, justifying further investigation in the treatment of locally advanced lung cancers.

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Endobronchial Ultrasound–Guided Transbronchial Needle Injection for Local Control of Recurrent Non–Small Cell Lung Cancer

Abstract: This is the first description of EBUS-TBNI to treat local recurrence of lung cancer and one of the first reports of the use of EBUS for intratumoral therapy. Additional research is warranted to determine the clinical usefulness and safety of this therapeutic approach.

Cited by 38 publications

References 9 publications

A case report of local treatment of inoperable squamous cell lung carcinoma with convex-probe endobronchial ultrasound-guided intratumoral injection of cisplatin in a patient with severe COPD

A case report of local treatment of inoperable squamous cell lung carcinoma with convex-probe endobronchial ultrasound-guided intratumoral injection of cisplatin in a patient with severe COPD

Endobronchial Ultrasound (EBUS) for Local Drug Application: Future Methodology

Endobronchial ultrasound—guidance for interstitial photodynamic therapy of locally advanced lung cancer—a new interventional concept

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