Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration/Biopsy (EBUS-TBNA/B): 5-Year Experience of a Referral Center in Greece

Gaga, Mina; Chrysikos, Serafeim; Bostantzoglou, Clementine; Kontogianni, Chrysoula; Iliopoulou, Marianthi; Ntontsi, P.; Samitas, K.; Ζervas, Εleftherios

doi:10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2359

Cited by 2 publications

(3 citation statements)

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“…Currently, minimally invasive techniques such as EBUS-TBNA alone, or combined with EUS-b FNA have widely used in biopsy sampling most mediastinal lymph node stations except the paraaortic and pre-vascular ones. On the other hand, surgical interventions, including mediastinoscopy, require general anesthesia and harbor high operative risk (14)(15)(16)(17)(18)(19)(20)(21). EBUS-TBNA has demonstrated superiority compared to CT and PET/CT in several studies with sensitivity, specificity, PPV and NPV of 89%, 100%, 100%, and 91%, respectively (8,(22)(23)(24).…”

Section: Introductionmentioning

confidence: 99%

Clinical utility of thoracic endosonography (EBUS/EUS-b) in mediastinal staging of patients with non-small cell lung cancer: comparison with integrated PET/CT—a real-life prospective study in Greece

Chrysikos¹,

Gkiozos²,

Dimakou³

et al. 2020

J Thorac Dis

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Background: Accurate mediastinal staging in patients with non-small cell lung cancer (NSCLC) is crucial for the determination of optimal treatment management. Methods: This was a real-life prospective study enrolling 140 patients between December 2016 and August 2018. We aimed to determine the clinical utility of EBUS/EUS-b in mediastinal staging of patients with NSCLC in comparison with integrated PET/CT. Furthermore, SUV max cut-off value with the highest specificity/accuracy was evaluated. Subgroup analysis according to histological type was performed.Results: One hundred and thirty patients were eligible for analysis (mean age ± SD: 67.6±7.6, males 97).Three hundred different lymph node stations were sampled (272 through EBUS-TBNA and 28 through EUS-b FNA). Mean SUV max of all malignant lymph nodes was 7.46 (SD =5.54). Sensitivity, specificity, PPV and NPV of EBUS/EUS-b for the identification of mediastinal malignant lymph nodes was 93.

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Section: Introductionmentioning

confidence: 99%

Clinical utility of thoracic endosonography (EBUS/EUS-b) in mediastinal staging of patients with non-small cell lung cancer: comparison with integrated PET/CT—a real-life prospective study in Greece

Chrysikos¹,

Gkiozos²,

Dimakou³

et al. 2020

J Thorac Dis

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“…Endobronchial ultrasound‐guided transbronchial needle aspiration (EBUS‐TBNA) alone or combined with endoscopic ultrasound fine‐needle aspiration (EUS‐b FNA) represents a novel, rapidly growing diagnostic modality for the evaluation of different intrapulmonary and mediastinal lesions 1‐8 . EBUS/EUS‐b has been established as an accurate, 3,5,9 safe, 10,11 and cost‐effective 12,13 minimally invasive procedure mainly for the diagnosis and staging of lung cancer as well for the evaluation of mediastinal or hilar lymphadenopathy of unknown origin, 14‐16 including sarcoidosis, 17,18 tuberculosis, 19,20 extrathoracic malignancies, 21 and lymphoma 22 …”

Section: Introductionmentioning

confidence: 99%

“…as well for the evaluation of mediastinal or hilar lymphadenopathy of unknown origin, [14][15][16] including sarcoidosis, 17,18 tuberculosis, 19,20 extrathoracic malignancies, 21 and lymphoma. 22 Lung cancer represents the main cause of cancer-related deaths worldwide, leading to approximately 1.4 million deaths per year and a 5-year survival rate of 19%.…”

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confidence: 99%

Thoracic endosonography (EBUS/EUS‐b) in the diagnosis of different intrathoracic diseases: A 4‐year experience at a single‐centre in Greece

et al. 2020

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Background In the last decade, the advent of thoracic endosonography has revolutionised the field of diagnostic bronchoscopy. Methods We conducted a single‐centre prospective study in “Sotiria” Chest diseases hospital between January 2016 and December 2019. The study aimed to evaluate the efficacy and diagnostic value of combined EBUS/EUS‐b in comparison with EBUS‐TBNA and EUS‐b FNA in different intrathoracic diseases. Results A total of 266 patients were enrolled (70.7% males, 85.7% smokers, mean age ± SD: 62.8 ± 11.8). Diagnosis and staging of suspected lung cancer (LC) were the main indications for EBUS/EUS‐b in 56.7% of patients, followed by lymphadenopathy of unknown origin in 27%, lymphadenopathy in previous malignancy in 10.9%, and staging of proven LC in 5.3%. EUS‐b FNA alone or combined with EBUS‐TBNA was performed in 14.7% of patients. A total of 512 lymph nodes was sampled (481 through EBUS‐TBNA and 31 through EUS‐b FNA). EBUS/EUS‐b led to a definitive diagnosis in 68.4% of the patients. Most cases (50.4%) were malignancies, while 18% represented benign diseases (83.3% sarcoidosis). Sensitivity of combined EBUS/EUS‐b was higher in comparison with sensitivity of both procedures alone (100% vs 89.4% vs 88.9%). Accordingly, the overall sensitivity of EBUS/EUS‐b for the detection of malignancy and sarcoidosis was 93% and 95.2%, respectively. No severe complications were observed. Conclusion Thoracic endosonography is an efficient, safe, minimally invasive tool yielding high sensitivity and diagnostic accuracy in patients with suspected malignancy and mediastinal lymphadenopathy. Experienced pulmonologists in EBUS‐TBNA should more routinely perform EUS‐b FNA to avoid unnecessary surgical interventions.

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Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration/Biopsy (EBUS-TBNA/B): 5-Year Experience of a Referral Center in Greece

Cited by 2 publications

References 0 publications

Clinical utility of thoracic endosonography (EBUS/EUS-b) in mediastinal staging of patients with non-small cell lung cancer: comparison with integrated PET/CT—a real-life prospective study in Greece

Clinical utility of thoracic endosonography (EBUS/EUS-b) in mediastinal staging of patients with non-small cell lung cancer: comparison with integrated PET/CT—a real-life prospective study in Greece

Thoracic endosonography (EBUS/EUS‐b) in the diagnosis of different intrathoracic diseases: A 4‐year experience at a single‐centre in Greece

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