Endobronchial metastasis from a primary uterine osteosarcoma in a patient with multiple myeloma: Report of a case

Abstract

We present herein the case of a 75-year-old woman with multiple myeloma who underwent a left lower lobectomy for endobronchial metastasis from an uterine osteosarcoma. She had initially been admitted to our hospital for chemotherapy more than 1 year earlier, soon after which a primary uterine osteosarcoma was discovered and a total abdominal hysterectomy and bilateral salpingo-oophorectomy performed. One year after the operation, the patient developed hemoptysis. A flexible bronchofiberscopy demonstrated a polypoid mass obstructing the left basal bronchus, and computed tomographic scans showed three pulmonary nodules. Surgery was performed to control the hemoptysis. At thoracotomy, two metastatic nodules were identified in the left lower lobe, and the endobronchial extension of the tumor was resected en bloc with the left lower lobe. The tumor was diagnosed as lung metastasis from the uterine osteosarcoma. Although further lung tumors have recently appeared, the patient has remained well for the 3 years since her last operation without any hemoptysis.

Endobronchial metastasis: An epidemiologic and clinicopathologic study of 174 consecutive cases

“…Another interesting aspect concerns the capacity of virtually all solid tumors of various cell differentiation to produce endobronchial metastases. So far, this fact was only documented by sporadic single case descriptions [25][26][27][28][29][30]. Regarding the clinical/radiological presentation, collected data strongly confirm the literature findings [3][4][5][6]10,11,32,33], and reassert evidence of a presentation that is difficult to differentiate from that of a primary pulmonary tumor.…”

Concurrent Multiple Myeloma and Metastatic Osteosarcoma: A Case Report and Literature Review

“…While both OS and MM are not uncommon, the concurrent presence of both malignancies is extremely rare. Only two other case reports of concurrent OS and MM are present in the literature [ 9 - 10 ]. One case report described a patient with MM developing a primary uterine OS with metastasis to the lungs and left bronchus [ 9 ].…”

“…Only two other case reports of concurrent OS and MM are present in the literature [ 9 - 10 ]. One case report described a patient with MM developing a primary uterine OS with metastasis to the lungs and left bronchus [ 9 ]. The second case, reported in Europe, discussed a patient with MM who was treated with radiation and chemotherapy and subsequently developed primary bone OS within the radiation field 19 years after the initial MM diagnosis [ 10 ].…”

Low grade fibromyxoid sarcomas and multiple myeloma in the same patient: One case report and literature review

“…The primary bone tumor was histologically established as myeloma, and was treated by radiation and multiple-drug chemotherapy. The secondary tumor, histologically confi rmed 19 years later, was osteogenic sarcoma occurring in the radiation field when clinical and laboratory examinations showed remission of the primary lesion [26] .…”

“…Solid tumors secondary to MM were sporadically reported, including lung cancer, hepatoma, bladder carcinoma and adenocarcinoma of the colon, glioblastoma, prostate adenocarcinoma, breast carcinoma, endometrial carcinoma, and soft tissue sarcoma [24][25][26][27][28][29] . In a retrospective analysis of a series of 210 patients with myeloma, solid malignancies were observed in 6.2% of patients with myeloma and occured at an advanced stage, IgG myelomas predominated in early stages.…”