Endobronchial Inflammatory Pseudotumor

Abstract

Inflammatory pseudotumors of the lung are a group of non-neoplastic tumors, which are mainly of parenchymal origin and rarely endobronchial. We report a case of a 9-year-old girl who presented with left-sided tension pneumothorax and subcutaneous emphysema. After emergency management, chest computed tomography revealed an ill-defined left lung mass. Rigid bronchoscopy revealed a mass occluding the left main bronchus at the origin of the left upper lobe bronchus. Initially, the mass was thought to be a foreign body granuloma. Few weeks later, the child presented with recurrence of the same clinical, radiologic, and bronchoscopic outcomes. Histologic examination after the repeat bronchoscopic excision revealed the lesion to be consistent with inflammatory pseudotumor. Left upper lobectomy was performed with a complete resolution of symptoms and no recurrence was observed during the 2 years of follow-up. To the best of our knowledge, this is the first reported case of inflammatory pseudotumor presenting with tension pneumothorax.

Pulmonary Inflammatory Myofibroblastic Tumor in Children: A Case Report and Brief Review of Literature

“…Although recurrence is described as a rare phenomenon (14% of pulmonary IMT) a close follow-up should be made for the early recognition of tumor relapse. In addition, the local invasion at diagnosis was highly correlated with local relapse ( 9 , 11 , 37 ).…”

Inflammatory myofibroblastic tumor of the upper airways harboring a new TRAF3-ALK fusion transcript.

“…All the patients have a histological diagnosis of IMT, but ALK status was reported in only five cases. Treatment strategy are listed in Supplemental Table 1 [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] . Aggressive surgery was the primary approach considering the critical condition in more than 50% of patients.…”

Flexible bronchoscope for the treatment of intratracheal inflammatory myofibroblastic tumor in children: a case report and literature review

“…Bronchoscopy and transbronchoscopic biopsy are necessary for the evaluation, diagnosis and treatment of airway obstructive injury (25)(26). Studies have found that the diagnosis of IMT is mainly determined by histopathology and immunohistochemical examination through biopsy (13)(14)(15)(16)(17)(18)(19)(20)(21). The pathological manifestations of IMT are as follows: [1] A large number of proliferating spindle cells are arranged in bundles; [2] The nuclei may be slightly heteromorphic, with mitotic images occasionally seen; [3] Lack of pathological mitosis and coagulation necrosis; [4] A mixture of spindle cells, lymphocytes, plasma cells and eosinophils existed (2,27).…”