Endobronchial fibroleiomyomatous hamartoma: a diagnostic pitfall

Dutta, Rimlee; Kumar, Arvind; Tanveer, Nadeem; Jindal, Tarun; Khilnani, Gopi C

doi:10.1007/s11748-009-0535-9

Cited by 5 publications

(6 citation statements)

References 9 publications

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“…Indeed, in a review of 215 cases of pulmonary hamartomas reported, only one case similar to our cases was found . To our knowledge, seven tumors, which were characterized by histopathologic appearances of a well‐circumscribed single nodule composing only of smooth‐muscle cells and columnar epithelial cells without cartilage and fat tissue, have been found in the English literature . Different diagnostic terms including adenofibroma, adenomyomatous hamartoma, and fibroleiomyomatous hamartoma have been applied to them.…”

Section: Discussionsupporting

confidence: 63%

“…2 To our knowledge, seven tumors, which were characterized by histopathologic appearances of a well-circumscribed single nodule composing only of smooth-muscle cells and columnar epithelial cells without cartilage and fat tissue, have been found in the English literature. 2,7,8,10,[12][13][14][15][16] Different diagnostic terms including adenofibroma, adenomyomatous hamartoma, and fibroleiomyomatous hamartoma have been applied to them. The clinicopathological features of the reported cases have been summarized ( Table 2).…”

Section: Discussionmentioning

confidence: 99%

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A case of pulmonary hamartoma with distinctive histopathological features: A discussion of its differential diagnosis and histogenesis

Okihara

Umeda

Otara

et al. 2014

Pathology International

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We herein describe a case of a benign pulmonary tumor with distinctive histopathological features. A 55-year-old Japanese male presented with a well-demarcated tumor in the left upper lobe of his lung, which gradually increased in size from 18 to 21 mm over 24 months. The resected tumor consisted of an epithelial component of compact irregular glands and mesenchymal component of fascicles between the glands. The differentiation of pneumocytes and smooth muscle cells was immunohistochemically detected in the epithelial component and the mesenchymal component, respectively. No mitosis, necrosis, bleeding, or invasion was observed. A histopathologic diagnosis of fibroleiomyomatous hamartoma was made. We also review previously reported tumors with similar histopathological features and discuss their differential diagnosis and histogenesis.

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

A case of pulmonary hamartoma with distinctive histopathological features: A discussion of its differential diagnosis and histogenesis

Okihara

Umeda

Otara

et al. 2014

Pathology International

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“…In our case, the bronchial epithelium extended into the alveolar septa in the pulmonary parenchyma without a cartilaginous or adipose element. the lesion may be solitary or multiple in single or double lung, may occur in any part of the lung parenchyma, even occur in the bronchus with polypoid blocking of the bronchial lumen [4]. Three cases reported in this group had single and multiple, all occurred in the lung parenchyma.…”

Section: Discussionmentioning

confidence: 64%

Three unusual Pulmonary fibroleiomyomatous hamartomas: cases report and literature review

Song

Wang

Fu³

2021

Preprint

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BackgroundPulmonary fibroleiomyomatous hamartomas (PFLH) is an extremely rare benign leision, characterized by most patients have no respiratory symptoms and pulmonary nodules is found during rutine chest imaging. It’s completely different from fibrochondrolipoma (ie.chondrogenic pulmonary hamartoma, FCL), Herein, we report three unusual cases of PFLH in a 48-year-old male patient, a 63-year-old male patient and a 63-year-old female patient,respectively and discuss their morphological characteristics and differential diagnoses including fibrochondrolipoma (FCL), pulmonary fibroadenoma (PFA), primary pulmonary leiomyoma (PPL), bronchioloalveolar adenoma (BAA), solitary fibrous tumor (SFT) and pulmonary metastatic leiomyoma (PML) in female patients.Case presentationThree cases showed singler and multiple nodules in the pulmonary parenchyma,the boundary of these nodules was clear. it showed swelling growth and lobulated in larger tumors. it consisted of the mesenchymal rich in spindle cells and the glandular epithelium tissue. the spindle cells form smooth muscle tissue and fibrous tissue, the glandular epithelium with invagination showed glandular ducts or fissures, disorder of composition. Immunohistochemical staining showed Desmin, SMA,H-caldesmon-positive in the all spindle cells; H-caldesmon-positive, SMA-weak positive and desmin-negative in the long spindle cells; TTF-1,CK7 were positive in glandular epithelium and P63,CK5/6 were expressed in basal cells; HMB45,S-100,CD34, ER,PR were negative in all cells. Additionally, Ki-67 VPI was low and less than 1%. The immunohistochemical analysis combined with the morphological results supported the diagnosis of solitary PFLH (SPFLH) or multiple PFLH (M PFLH). There was no recurrence in SPFLH and recurrence in MFLH in the group.ConclusionsPFLH is a rare benign leision .It originated from the small bronchus or smooth muscle cells of vascular wall which implanted into the lung parenchyma and overgrowth into nodules or mass, the messenchymal component of PFLH is the most important for accurate pathological diagnosis, PFLH is easy to be confused with PFA and PPL when there are not enough immune marker such as SMA,desmin, H-caldesmon to mark the mesenchymal components. Therefore, Diagnosis of PFLH mainly depends on pathological examination, females patients have to exclude PML.

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“…Genellikle histopatolojik olarak tanı zorluğu olmamakla birlikte nadir histolojik varyantlar (fibroleiomyomatöz vb.) tanı karışıklığına neden olabilir (18). Olgularımızda baskın olan histopatolojik özellik kondroid tipte olup tanı zorluğu yaratan histolojik varyant izlenmemiştir.…”

Section: Introductionunclassified

Pulmoner Hamartom; Klinik, Radyolojik ve Patolojik Özellikleri Eşliğinde 10 Yıllık Hastane Deneyimimiz

Bulut¹,

Uzun²

2018

Akd Med J

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Akciğerin benign lezyonu olan pulmoner hamartom nadir bir lezyondur ve soliter pulmoner nodüllerin %6'sını oluşturur. Çalışmada, hastanemizde tanı alan, 10 pulmoner hamartom olgusunun klinik, radyolojik ve patolojik özellikleri incelenmiştir. Gereç ve Yöntemler: Ocak 2006 ile Aralık 2016 tarihleri arasında hastane dosya arşivi ve bilgisayar verileri retrospektif olarak incelendi. Bulgular: Olguların yaş ortalaması 52,3 yıl (33-67yıl) olup, altı olgu kadın, dört olgu erkekti. Yedi olgu semptomatik olup bir olguya eş zamanlı akciğer adenoskuamöz karsinomu eşlik etmekte idi. Lezyonların çoğunluğu (%60) sol akciğerde yerleşimli ve ortalama çapı 3,12 cm (1-6 cm) idi. Tüm olgular periferik yerleşimliydi. Yalnızca bir olguda (%16,6) popcorn kalsifikasyon izlendi. Tüm olgulara wedge rezeksiyon ve kitle enükleasyonu içeren akciğeri koruyucu cerrahi uygulandı. Eksizyon sonrası, ortalama 36,23 ay (25 gün-113 ay) takip süresi boyunca nüks veya malignite gelişimi izlenmedi ve pulmoner hamartom nedenli ölüm olmadı. Sonuç: Akciğer kanseri ayırıcı tanısı nedeniyle pulmoner hamartom önemlidir. Radyolojik olarak ancak %34-50 oranında tanı verilebildiği için multidisipliner davranmanın gerekli olduğu, klinik ve radyolojik bulgular eşliğinde ince iğne aspirasyon veya tru-cut biyopsi kullanılarak tanı konulabileceği ve cerrahi uygulanmaksızın güvenle takip edilebileceği unutulmamalıdır. Cerrahi sonrası ise takip gerekli değildir.

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Endobronchial fibroleiomyomatous hamartoma: a diagnostic pitfall

Cited by 5 publications

References 9 publications

A case of pulmonary hamartoma with distinctive histopathological features: A discussion of its differential diagnosis and histogenesis

A case of pulmonary hamartoma with distinctive histopathological features: A discussion of its differential diagnosis and histogenesis

Three unusual Pulmonary fibroleiomyomatous hamartomas: cases report and literature review

Pulmoner Hamartom; Klinik, Radyolojik ve Patolojik Özellikleri Eşliğinde 10 Yıllık Hastane Deneyimimiz

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