Endobronchial adenocarcinoma with endometrioid features and prominent neuroendocrine differentiation. A variant of fetal adenocarcinoma

Mardini, George; Tomashefski, Joseph F.; Pai, Usha; Chavez, Altagracia M.

doi:10.1002/1097-0142(19940301)73:5<1383::aid-cncr2820730512>3.0.co;2-v

Cited by 19 publications

(11 citation statements)

References 14 publications

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“…[3] Histologically the tumor is composed of neoplastic glands and tubules lined by non-ciliated columnar cells, with infra-and supranuclear vacuoles mimicking secretory endometrial glands. [6] These glands are rich in glycogen, as demonstrated by the PAS staining.…”

Section: Discussionmentioning

confidence: 91%

“…[3] Well-differentiated fetal adenocarcinoma is of low-grade malignant potential and associated with a low mortality rate, hence, it is important to identify this tumor, based on the age, gender of the patients, cytological and nuclear features of the glands, and appearance of the stroma. [6,10] Poor prognosis is associated with the presence of thoracic lymphadenopathy, initial metastases, and tumor recurrence.…”

Section: Discussionmentioning

confidence: 99%

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Well-differentiated fetal adenocarcinoma of the lung in an adult male: Report of an unusual tumor with a brief review of literature

Patnayak¹,

Jena²,

Rukmangadha³

et al. 2014

J Can Res Ther

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We report a case of a well-differentiated fetal adenocarcinoma (WDFA) of the lung in a 50-year-old male smoker. The literature regarding this uncommon tumor is limited. This rare variant of adenocarcinoma is more common in females, in the third and fourth decades. Microscopically it is composed of neoplastic glands and tubules that resemble the fetal lung. Well-differentiated fetal adenocarcinoma is a low-grade malignancy and surgery is the preferred mode of therapy. This uncommon case of a well-differentiated fetal adenocarcinoma in an adult male patient is reported, with relevant immunohistochemical findings, along with a discussion of the current literature.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Well-differentiated fetal adenocarcinoma of the lung in an adult male: Report of an unusual tumor with a brief review of literature

Patnayak¹,

Jena²,

Rukmangadha³

et al. 2014

J Can Res Ther

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“…M orules have been reported in well differentiated fetal adenocarcinoma of the lung (WDFA) and in pulmonary blastoma (PB), [1][2][3][4][5][6] and it has also been reported that morules show neuroendocrine differentiation. Morule formation in such tumours has also been reported to be associated with b catenin gene mutation.…”

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confidence: 99%

Morules and morule-like features associated with carcinomas in various organs: report with immunohistochemical and molecular studies

Makishi

Kinjo²,

Sawada³

et al. 2006

J Clin Pathol

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Background: Morules have been reported in pulmonary blastoma (PB), well differentiated fetal adenocarcinoma of the lung (WDFA), and uterine endometrioid carcinoma (EC), and rarely in other carcinomas. b Catenin gene mutation has been associated with morule formation. Aims: To compare and clarify the cellular characteristics of morules in carcinomas in various organs and show that morules are distinct from epithelial cellular nodules. Methods: Twenty tumours were studied: two PBs, three WDFAs, three papillary lung adenocarcinomas, 11 ECs, and one papillary thyroid carcinoma. Numerous epithelial cell, oncofetal, and neuropeptide antibodies were used for immunohistochemistry. b Catenin gene mutation was investigated. Results: Morules in PBs and ECs were uniform cell clusters distinct from squamous differentiation. All were immunonegative for epithelial cell and oncofetal antigens, but those in ECs were positive for neurone specific enolase c (NSEc). Synaptophysin, encephalin, and somatostatin were sporadically immunopositive in PB morules. Morules were not seen in the other carcinomas and WDFAs, although morule-like features closely resembling morules histopathologically were seen. These were positive for epithelial cell and oncofetal antigens, and showed squamous differentiation. Their nuclei were more atypical and slightly larger than those in morules. Morule-like features were seen in WDFAs. b Catenin gene mutation was demonstrated in one EC and PB, and in two WDFAs. Conclusion: Morules were non-epithelial cell clusters showing neuronal differentiation. There were two types: endometrioid type, expressing NSEc, and blastoma type, expressing neuropeptides. In contrast, similar morule-like features were epithelial nodules. Although the number of cases was small, the presence of morules showed no clear prognostic correlations.

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“…The presence of characteristic extranuclear vacuoles, rich in glycogen, makes adenocarcinoma resemble uteral mucosa in the secretion phase [4]. The specific feature of this carcinoma is the presence of argyrophil cells with neurosecretion activity [5,6].…”

Section: Introductionmentioning

confidence: 99%

“…In the patients with a diagnose of a poorly differentiated form of this tumour, with a high-grade of malignancy, the prognosis depends also on morphological components of the adenocarcinoma which are present in the architecture of fetal adenocarcinoma [5].…”

Section: Introductionmentioning

confidence: 99%

Fetal adenocarcinoma — a rare variant of lung adenocarcinoma with good prognosis

Winek¹,

Caban²,

Zych³

et al. 2017

Nowotwory. Journal of Oncology

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Fetal adenocarcinoma (FA) is a rare variant of lung adenocarcinoma with a good prognosis which represents approximately 0.5% of all primary lung neoplasms. The tumour has nonciliated tubules with morules in the lumen resembling fetal lung at 10 to 16 weeks of gestation. FA typically occurs in young patients 75-80% of whom are tobacco smokers. FA occurs in low-and high-grade forms. Surgical procedure is usually necessary to obtain final diagnosis and a complete surgical resection is the standard treatment. The 5-year survival rate for FA is about 75-80%. We report a case of 32-year-old male, a smoker, who had an incomplete regression of parenchymal consolidations after antibiotic treatment, which led to further diagnostics. An intravenous tumour in one of the pulmonary veins with concomitant development of collateral circulation and pulmonary venous infarction were additional diagnostic problems. Based on the intraoperative microscopic examination, fetal adenocarcinoma was diagnosed. An upper right bilobectomy with intrapericardial ligation of the right superior pulmonary vein was performed as radical treatment. At the 9-month follow-up stage, there has been no evidence of disease recurrence. NOWOTWORY J Oncol 2016; 66, 5: 381-385

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Endobronchial adenocarcinoma with endometrioid features and prominent neuroendocrine differentiation. A variant of fetal adenocarcinoma

Cited by 19 publications

References 14 publications

Well-differentiated fetal adenocarcinoma of the lung in an adult male: Report of an unusual tumor with a brief review of literature

Well-differentiated fetal adenocarcinoma of the lung in an adult male: Report of an unusual tumor with a brief review of literature

Morules and morule-like features associated with carcinomas in various organs: report with immunohistochemical and molecular studies

Fetal adenocarcinoma — a rare variant of lung adenocarcinoma with good prognosis

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