Endoamnioscopy and fetal biopsy: A new technique

Valenti, Catherine

doi:10.1016/0002-9378(72)90220-7

Cited by 61 publications

(10 citation statements)

References 4 publications

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“…This was the first case of open fetal surgery. Early in the 1970s, Carlo Valenti performed the first fetoscopy and also the first umbilical blood sampling under fetoscopy guidance26, 27. This technique was extensively used in Europe by Dr Charles Rodeck and his group28, and in the United States by Dr John Hobbins and Dr Jeremiah Mahoney29.…”

Section: Is Rhesus (Rh) Alloimmunization Still a Problem?mentioning

confidence: 99%

Middle cerebral artery peak systolic velocity for the diagnosis of fetal anemia: the untold story

Mari

2005

Ultrasound in Obstet & Gyne

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Section: Is Rhesus (Rh) Alloimmunization Still a Problem?mentioning

confidence: 99%

Middle cerebral artery peak systolic velocity for the diagnosis of fetal anemia: the untold story

Mari

2005

Ultrasound in Obstet & Gyne

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“…Human fetal blood would be obtained from an umbilical blood vessel by fetoscopy [Valenti, 1972;Hobbins and Mahoney, 1974;Rodeck and Campbell, 1979;Romero et al, 19861. A midtrimester diagnosis of CHS would be possible by this method.…”

Section: Resultsmentioning

confidence: 99%

Chediak‐Higashi syndrome: Prenatal diagnosis by fetal blood examination in the feline model of the disease

Kahraman¹,

Prieur²

1989

Am. J. Med. Genet.

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Chediak-Higashi syndrome (CHS) is an autosomal recessive disease of humans, mink, cattle, mice, killer whales, cats, and blue and silver foxes. The disease is characterized by incomplete oculocutaneous albinism, recurrent and severe pyogenic infections, a bleeding tendency secondary to a platelet storage pool deficiency, and enlarged granules in many types of cells. Humans with CHS usually die during childhood. It has been suggested that the prenatal diagnosis of CHS should be possible by the demonstration of enlarged granules in neutrophils of fetal blood. We tested this hypothesis using 20 cat fetuses obtained 18 days at prepartum. Two litters (6 fetuses) were from CHS to CHS matings and four litters (14 fetuses) were from CHS male to heterozygous female matings. Fetuses were identified as CHS or phenotypically normal by histologic examination of the size of melanin granules in the ciliary body and by the size of periodic acid-Schiff-positive granules in renal tubular epithelial cells. The diameter of the peroxidase-positive granules in neutrophils of the 15 CHS fetuses ranged from 0.3 to 3.0 microns whereas those of the five normal fetuses ranged from 0.3 to 1.0 micron. All 20 fetuses were correctly classified as CHS or phenotypically normal. These data indicate that examination of the size of fetal blood neutrophil granules can be used to diagnose CHS prenatally.

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“…In the last case, vigorous limb movements of the fetus were seen as well as swallowing more than 30 times per minute. Much later, during the 1970s, Scrimgeour and Valenti [2,3] performed direct endoscopic examinations of fetuses via a laparotomy and incision in the myometrium. Eventually, in the 1980s, a new technique ("fetoscopy") allowed the introduction of a scope transabdominally under real-time ultrasound guidance for close examination of the fetus in utero, as well as for sampling of fetal blood, skin, and other tissue [4,5].…”

Section: Introductionmentioning

confidence: 99%

Embryofetoscopy: a new “old” tool

et al. 2006

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Embryoscopy is the direct visualization of the embryo between 5 and 8 weeks' gestational age. Fetoscopy is the direct visualization of the fetus after 8 weeks of gestation. Both are performed by inserting a fiber-optic scope, either transabdominally or transcervically, into the extracelomic space when the procedure is done before 11 weeks or inside the amniotic cavity when it is done after 11 weeks. Embryofetoscopy is likely to find applications in confirming and further clarifying our knowledge of embryonic development and in the prenatal investigation of high-risk pregnancies for recurrent genetic disorders. Further evolution of endoscopic instruments and embryoscopic technique could give embryofetoscopy a potential for early gene and cell therapy as well as for surgery in utero. We also present our preliminary experience using transcervical embryoscopy for direct visualization of the 1st-trimester embryo in women opting to terminate pregnancy.

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Endoamnioscopy and fetal biopsy: A new technique

Cited by 61 publications

References 4 publications

Middle cerebral artery peak systolic velocity for the diagnosis of fetal anemia: the untold story

Middle cerebral artery peak systolic velocity for the diagnosis of fetal anemia: the untold story

Chediak‐Higashi syndrome: Prenatal diagnosis by fetal blood examination in the feline model of the disease

Embryofetoscopy: a new “old” tool

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