Endless variety for bovine virus diarrhea viruses: new members of a novel subgroup into Pestivirus A from Turkey

Oğuzoğlu, Tuba Çiğdem; Koç, Bahattin Taylan; Coşkun, Nüvit; Doğan, Fırat; Duran-Yelken, Selda

doi:10.1007/s11250-018-01787-w

Cited by 7 publications

(4 citation statements)

References 20 publications

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“…Previously, BVDV‐1a, 1b, 1c, 1d, 1f, 1h, 1i, 1l, 1r and 1v; BVDV‐2a and 2b; and HoBi‐like pestiviruses were detected in samples originating from the cattle in Turkey. Additionally, it has been reported that BVDV‐1l is predominant in cattle and widespread in Turkey (Yesilbag et al., 2008, 2017; Oguzoglu, Koc, Coskun, Dogan, & Duran‐Yelken, 2019; Oguzoglu et al., 2012; Timurkan & Aydın, 2019). However, in this study Aydin‐like pestivirus was found to be the predominant genotype (33.3%, 8/24) in bovine foetuses.…”

Section: Discussionmentioning

confidence: 99%

Genomic characterization of pestiviruses isolated from bovine, ovine and caprine foetuses in Turkey: A potentially new genotype of Pestivirus I species

Şevik

2020

Transbounding Emerging Dis

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This study was carried out to investigate the frequency and genetic diversity of pestiviruses in abortion cases in cattle and small ruminants in Turkey. During January 2012 and December 2017, a total of 2029 aborted foetuses (553 bovine foetuses, 1,388 sheep foetuses and 88 goat foetuses) were collected from different regions of Turkey. Real-time RT-PCR (RRT-PCR) assays were used to detect pestiviral RNA in aborted foetuses. To confirm the cause of abortion, pestivirus-positive foetuses were also examined for the presence of Brucella spp., Campylobacter spp., Chlamydophila abortus (C. abortus), akabane virus, bluetongue virus and Schmallenberg virus by molecular detection methods. Pestiviral RNA was detected in 61 (11%) of the 553 bovine foetuses, 124 (8.9%) of the 1,388 sheep foetuses and 3 (3.4%) of the 88 goat foetuses. Furthermore, C. abortus DNA was detected in 3 pestivirus-positive sheep foetuses, whereas other infectious agents were not detected in pestivirus-positive foetuses. Genetic characterization of the pestivirus RRT-PCR positive samples was conducted by sequencing 5′ untranslated (5′ UTR) and non-structural autoprotease (N pro ) genomic regions. A total of 68 sequences were obtained, and phylogenetic analyses revealed that all sequences belonged to BVDV-1, including 1b (8/68), 1f(2/68), 1l (4/68), 1r (10/68), Aydin-like pestivirus (20/68) and one unknown genotype (24/68). The 5′ UTR and N pro sequences of this unknown genotype differed from pestiviruses previously described, providing evidence for the presence of an emerging genotype within the species Pestivirus I, tentatively named as 'Konya-like' pestivirus. 'Konya-like' pestivirus was the dominant genotype in sheep foetuses, whereas Aydin-like pestivirus was found to be the predominant genotype in bovine foetuses.To the best my knowledge, this is the first report of Aydin-like pestivirus infection in cattle. The information provided in this study contributes to the understanding the dissemination and evolution of pestiviruses and could be beneficial for developing more effective vaccines.

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Section: Discussionmentioning

confidence: 99%

Genomic characterization of pestiviruses isolated from bovine, ovine and caprine foetuses in Turkey: A potentially new genotype of Pestivirus I species

Şevik

2020

Transbounding Emerging Dis

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“…However, the third region is the coding region of E2 protein also showed high variability and was frequently used for genotyping of Pestiviruses (8). Based on partial or complete genome sequencing, BVDV-1 has been classified into at least 22 subtypes (BVDV-1a to BVDV-1v) (24) while BVDV-2 and HoBi-like virus divided into 4 subtypes (a to d) (25).…”

Section: Genome Structure and Organization Of Bvdvmentioning

confidence: 99%

Recent Advances on the Bovine Viral Diarrhea Virus Molecular Pathogenesis, Immune Response, and Vaccines Development

et al. 2021

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The bovine viral diarrhea virus (BVDV) consists of two species and various subspecies of closely related viruses of varying antigenicity, cytopathology, and virulence-induced pathogenesis. Despite the great ongoing efforts to control and prevent BVDV outbreaks and the emergence of new variants, outbreaks still reported throughout the world. In this review, we are focusing on the molecular biology of BVDV, its molecular pathogenesis, and the immune response of the host against the viral infection. Special attention was paid to discuss some immune evasion strategies adopted by the BVDV to hijack the host immune system to ensure the success of virus replication. Vaccination is one of the main strategies for prophylaxis and contributes to the control and eradication of many viral diseases including BVDV. We discussed the recent advances of various types of currently available classical and modern BVDV vaccines. However, with the emergence of new strains and variants of the virus, it is urgent to find some other novel targets for BVDV vaccines that may overcome the drawbacks of some of the currently used vaccines. Effective vaccination strategy mainly based on the preparation of vaccines from the homologous circulating strains. The BVDV-E2 protein plays important role in viral infection and pathogenesis. We mapped some important potential neutralizing epitopes among some BVDV genomes especially the E2 protein. These novel epitopes could be promising targets against the currently circulating strains of BVDV. More research is needed to further explore the actual roles of these epitopes as novel targets for the development of novel vaccines against BVDV. These potential vaccines may contribute to the global eradication campaign of the BVDV.

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“…According to sequence comparisons of the BVDV 5'-UTR, BVDV was divided into two genotypes: bovine viral diarrhea virus type I (BVDV-1) and bovine viral diarrhea virus type II (BVDV-2) [3] . At present, according to comparisons of the 5'-UTR, N pro , and E2 sequences in the BVDV genome, BVDV-1 can be divided into 22 subtypes (1a-1v), and BVDV-2 can be divided into four subtypes [4][5][6][7] . Because of the high mutation rate of RNA viruses and increasingly frequent international exchange and trade, new subtypes of BVDV are still emerging.…”

Section: Introductionmentioning

confidence: 99%

Çin’de BVDV 1q’nun Tespiti: Patojenitesinin Araştırılması Amacıyla Genetik Karakterizasyon ve Deneysel Enfeksiyon

He¹,

Ma²,

Huang³

et al. 2020

Kafkas Univ Vet Fak Derg

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Bovine viral diarrhea virus (BVDV) is a pathogen that affects ruminants worldwide and is one of the most economically important diseases of cattle. Although BVDV infections have been increasingly reported in China, the pathogenesis and genetic characteristics of these BVDV isolates have not been thoroughly investigated. Here, we report the identification and characterization of a novel BVDV isolate, designated LC, which was isolated from the feces of a cattle with diarrhea. The complete genome of isolate LC was 12.271 nucleotides and contained a 5'-UTR of 389 nucleotides, a 3'-UTR of 189 nucleotides, and a large ORF encoding a polyprotein consisting of 3898 amino acids. Genomic comparisons and phylogenetic analyses of the complete genomic sequence clearly showed that the isolate was a BVDV-1q subtype. Experimental infection of calves with isolate LC resulted in the development of clinical signs including elevated rectal temperatures, nasal discharge and decreased leucopenia. Viral antigen was detected in infected animal tissues using immunohistochemistry. This is the first report of the genomic sequence of a BVDV-1q virus isolated from cattle. The virus strain was moderately pathogenic in calves and could potentially be used as a BVDV challenge virus to evaluate the efficacy of BVDV vaccines.

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Endless variety for bovine virus diarrhea viruses: new members of a novel subgroup into Pestivirus A from Turkey

Cited by 7 publications

References 20 publications

Genomic characterization of pestiviruses isolated from bovine, ovine and caprine foetuses in Turkey: A potentially new genotype of Pestivirus I species

Genomic characterization of pestiviruses isolated from bovine, ovine and caprine foetuses in Turkey: A potentially new genotype of Pestivirus I species

Recent Advances on the Bovine Viral Diarrhea Virus Molecular Pathogenesis, Immune Response, and Vaccines Development

Çin’de BVDV 1q’nun Tespiti: Patojenitesinin Araştırılması Amacıyla Genetik Karakterizasyon ve Deneysel Enfeksiyon

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