Endemic Pemphigus Foliaceus in Venezuela: Report of Two Children

González, Francisco; Sáenz, Ana María; Cirocco, Antonietta; Tacaronte, Inés María; Fajardo, Javier Guajardo; Calebotta, Adriana

doi:10.1111/j.1525-1470.2006.00197.x

Cited by 14 publications

(12 citation statements)

References 17 publications

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“…Geschlechtsunterschiede oder ethnische Zugehörigkeiten scheinen keine Rolle zu spielen, obwohl auffällt, dass in den Endemiegebieten Asiaten seltener als europäische oder afrikanische Einwanderer betroffen sind [16].…”

Section: Endemischer Pemphigus Foliaceus Bei Kindern Und Jugendlichenunclassified

Pemphiguserkrankungen bei Kindern und Jugendlichen

Meurer

2009

Hautarzt

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The pemphigus diseases, which include some of the most severe bullous autoimmune skin reactions, are seen predominantly in middle-aged and elderly individuals. Only endemic pemphigus foliaceus in South America most frequently affects juveniles and children. All non-endemic pemphigus diseases, including paraneoplastic pemphigus, have been reported to occur in adolescents and even very rarely in children younger than 10 years. Pemphigus vulgaris in pregnancy represents a frequently overseen medical problem and may result in fetal growth retardation, intrauterine death, premature delivery and - in about 30% - in neonatal pemphigus vulgaris of the newborn. Contrary to pemphigus vulgaris, the transplacental crossing of autoantibodies against desmoglein1 in pregnant women with pemphigus foliaceus hardly ever leads to neonatal skin lesions in the offspring. This phenomenon can be explained by differences in the distribution and cross-compensation of the pemphigus antigens desmoglein3 and 1 in neonatal and adult skin or mucosa, respectively.

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Section: Endemischer Pemphigus Foliaceus Bei Kindern Und Jugendlichenunclassified

Pemphiguserkrankungen bei Kindern und Jugendlichen

Meurer

2009

Hautarzt

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“…[5][6][7][8] However, there have been reports about other endemic foci, including El Salvador, Venezuela, Bolivia, Argentina, Uruguay, Paraguay and Peru. [9][10][11][12][13][14][15][16][17][18][19][20][21][22] Looking at Peru specifically, there are reports of cases from Peruvian areas located between longitude 70-78°west and latitude 0-10°south, in regions that are mainly part of the Peruvian Amazon region. The weather in these endemic areas is tropical and subtropical.…”

Section: Introductionmentioning

confidence: 99%

Endemic pemphigus foliaceus in the Peruvian Amazon

et al. 2013

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“…1 The disease has been reported in Brazil, Colombia, El Salvador, Paraguay, Tunisia and Venezuela, with variants in each country. 2-9 …”

Section: Introductionmentioning

confidence: 99%

Endemic pemphigus in the peruvian Amazon: epidemiology and risk factors for the development of complications during treatment

Ramos

Chacon

Galarza

et al. 2012

An. Bras. Dermatol.

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BACKGROUNDPemphigus is an autoimmune blistering disease. According to a report, in areas of endemic pemphigus foliaceus (EPF) in Peru there are cases of pemphigus vulgaris with epidemiologic, clinical and histopathologic characteristics similar to those of "endemic pemphigus vulgaris" (EPV) in Brazil. OBJECTIVESTo determine the clinical and epidemiologic characteristics of endemic pemphigus and the risk factors of patients for developing complications during treatment. METHODSA study was carried out from July 2003 to March 2008. The study population was 60 patients with EPF and 7 patients with EPV evaluated in hospitals and clinics in the Peruvian Amazon and Lima. A multivariate analysis was carried out using binary logistic regression. RESULTSThe average age of EPF patients was 31.4 years; 55% were men; 60% presented the generalized clinical variant. Non-compliance with the treatment was seen in 57.1% of the patients. Thirty-five percent presented complications (e.g. pyodermitis and pyelonephritis) during treatment. The risk factors for developing complications during treatment were non-compliance with the treatment and having the generalized clinical form. In the EPV group, the average age was 21.7 years; 71.4% were men. All patients presented with the mucocutaneous clinical variant and the initial presentation consisted of oral mucosa lesions; 71.4% presented complications during treatment, pyodermitis being the most frequent. CONCLUSIONSNon-compliance with the treatment and the generalized clinical form are risk factors for the development of complications during treatment of patients with EPF. Peru indeed has EPV cases with epidemiologic characteristics similar to EPF. Living in a rural area may represent a risk factor for the development of complications during treatment of patients with EPV.

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Endemic Pemphigus Foliaceus in Venezuela: Report of Two Children

Cited by 14 publications

References 17 publications

Pemphiguserkrankungen bei Kindern und Jugendlichen

Pemphiguserkrankungen bei Kindern und Jugendlichen

Endemic pemphigus foliaceus in the Peruvian Amazon

Endemic pemphigus in the peruvian Amazon: epidemiology and risk factors for the development of complications during treatment

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