Endemic Goiter and Iodine Deficiency in Turkey

Hatemi, Hüsrev; Urgancioglu, I

doi:10.1007/978-1-4899-1245-9_57

Cited by 4 publications

(5 citation statements)

References 1 publication

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“…Since the representative study by Gü r et al, identified significant associations of iodine deficiency with socioeconomic variables (27) and because it is known that large socioeconomic differences between Istanbul, Kocaeli and the iodine deficient regions were also present in the past, it is most likely that similar differences in iodine supply which have been documented by the studies described earlier were also present in the past. This assumption is also consistent with an earlier report (32) characterizing Istanbul and Kocaeli as cities with the lowest risk of endemic goiter.…”

Section: Patientssupporting

confidence: 93%

“…It rather suggests that constitutive activation of the cAMP cascade is a prerequisite for TTNs and is most frequently achieved through TSHR mutagenesis irrespective of the iodine status. Our patients were classified as iodine deficient, sufficient, or mixed group based on published UI excretion and endemic goiter prevalence (26)(27)(28)(29)(30)(31)(32). We are aware that this approach might be prone to a certain percentage of misclassification of patients (37)(38)(39).…”

Section: Discussionmentioning

confidence: 99%

“…This classification is based on the published prevalence of goiters in the respective areas of residence as detected by palpation (32). The patients classified as iodine deficient on the basis of the reported occurrence of endemic goiters in their areas of residency from 1980 to 1987 are labeled as 'iodine deficient GP' in Table 2.…”

Section: Patientsmentioning

confidence: 99%

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Similar prevalence of somatic TSH receptor and Gsα mutations in toxic thyroid nodules in geographical regions with different iodine supply in Turkey

Gözü

Bircan

Krohn³

et al. 2006

eur j endocrinol

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Objective: Differences in iodine intake could account for the variable prevalences reported for somatic TSH receptor (TSHR) mutations in toxic thyroid nodules (TTNs). However, this question has not been settled, since no study has yet determined the TSHR mutation prevalence in regions with different iodine supplies in the same population using the same methodology. Therefore, we studied the prevalence of somatic TSHR mutations in TTNs from patients living in iodine-deficient or -sufficient regions in Turkey. Design and methods: We screened 74 TTNs for somatic TSHR mutations. Exons 9 and 10 of the TSHR and 7 and 8 of the Gsa were screened by denaturing gradient gel electrophoresis. Determination of X-chromosome inactivation was used for clonality analysis. Results: TSHR mutations were identified in 52 (70.2%) of 74 TTNs. A Gsa mutation was identified in one TTN. Three new TSHR mutations were detected (A627V, I640K, I486N). No significant difference between frequencies of TSHR mutations in iodine deficient/sufficient regions was found. The frequency of non-random X-chromosome inactivation was similar in iodine-sufficient or -deficient regions and in TSHR mutation positive or negative hot nodules. Conclusions: These findings suggest that TTNs in iodine deficient/sufficient areas predominantly arise from aberrant growth of a single cell. Our results suggest that neither the prevalence of TSHR mutations nor that of monoclonal TTNs is related to iodine supply.European Journal of Endocrinology 155 535-545

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Section: Patientssupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

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Similar prevalence of somatic TSH receptor and Gsα mutations in toxic thyroid nodules in geographical regions with different iodine supply in Turkey

Gözü

Bircan

Krohn³

et al. 2006

eur j endocrinol

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“…[23] Existing data indicate that endemic goiter prevails in all geographical regions of Turkey and the East Black Sea Region is recognized as one of the highest prevalence rate region of the country. [24] A history of benign thyroid diseases, mostly goiter and nodules has now been considered as established risk factors for thyroid cancer. [10,25 -27] Long term residence in regions with iodine imbalance [10,28] and poor nutrition (a diet poor in vegetables and fruits, and hence in antioxidant nutrients) [29] are other recognized risk factors for thyroid tumors.…”

Section: Resultsmentioning

confidence: 99%

Oxidative DNA Base Damage, Antioxidant Enzyme Activities and Selenium Status in Highly Iodine-deficient Goitrous Children

Giray

Hıncal

2002

Free Radical Research

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The objective of this study was to investigate oxidative DNA damage, and the levels of antioxidant enzymes (AOE) and selenium (Se) in relation to iodine deficiency and/or goiter in children. The study was performed in a group of goitrous high school children (15 -18 years of age) ðn ¼ 14Þ with severe or moderate iodine deficiency. Thyroid hormones (TSH, FT 4 , TT 4 , FT 3 , TT 3 ), urinary iodine (UI) and plasma Se levels, and erythrocyte glutathione peroxidase (GSHPx), superoxide dismutase (SOD) and catalase (CAT) activities were determined and compared with those of a control group consisting of nongoitrous high school children ðn ¼ 14Þ with normal UI levels or mild iodine deficiency. In the goitrous group, concentrations of FT 4 , TT 4 , plasma Se and UI, and activities of GSHPx and SOD were found to be significantly lower. Six typical hydroxyl radical-induced base lesions in genomic DNA of peripheral blood were identified and quantified by gas chromatography/isotope-dilution mass spectrometry (GC/IDMS), and higher levels of DNA base lesions were observed in the goitrous group. The results suggest that highly iodine-deficient goitrous children may be under oxidative stress, which may lead to greater level of oxidative damage to DNA. This study supports the evidence for the reported relationship between iodine deficiency and the increased incidence of thyroid malignancies.

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“…Until recently, endemic goiter has prevailed in all geographical regions of Turkey and there has been no region with less than 2% goiter prevalence [3]. In a study conducted just before the mandatory iodization of salt which started in June 1999, goiter prevalence was found to be 26-52% in 4 cities [4].…”

Section: Iodine Defıciency In Turkeymentioning

confidence: 99%

Trace elements in growth: Iodine and selenium status of Turkish children

Hıncal

2007

Journal of Trace Elements in Medicine and Biology

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Endemic Goiter and Iodine Deficiency in Turkey

Cited by 4 publications

References 1 publication

Similar prevalence of somatic TSH receptor and Gsα mutations in toxic thyroid nodules in geographical regions with different iodine supply in Turkey

Similar prevalence of somatic TSH receptor and Gsα mutations in toxic thyroid nodules in geographical regions with different iodine supply in Turkey

Oxidative DNA Base Damage, Antioxidant Enzyme Activities and Selenium Status in Highly Iodine-deficient Goitrous Children

Trace elements in growth: Iodine and selenium status of Turkish children

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