Endemic fluorosis in Turkish patients: relationship with knee osteoarthritis

Savaş, Serpil; Çetin, Müjdat; Akdoğan, Mehmet; Heybeli, Nurettin

doi:10.1007/s002960100132

Cited by 42 publications

(25 citation statements)

References 19 publications

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“…These minerals are pyroxene, hornblende, biotite, fluorapatite, and glassy groundmass [2]. According to the Isparta Health Organization data, the mean fluoride level in drinking water was 2.74±064 ppm in the endemic fluorosis region, and 0.53± 0.06 ppm in the nonendemic region [3].…”

Section: Introductionmentioning

confidence: 99%

Aortic Elasticity is Impaired in Patients with Endemic Fluorosis

Varol

Akçay

Ersoy

et al. 2009

Biol Trace Elem Res

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Sixty-three patients with endemic fluorosis (36 males/27 females; mean age 33.9 +/- 8.6 years) and 45 age-, sex-, and body mass index-matched healthy controls (30 males/15 females; mean age 32.7 +/- 8.8 years) were included in this study. Aortic stiffness indices, aortic strain (AS), aortic distensibility (AD), and aortic strain index (ASI) were calculated from the aortic diameters measured by echocardiography and blood pressure obtained by sphygmomanometry. The urine fluoride levels of fluorosis patients were significantly higher than control subjects as expected (1.9 +/- 0.1 mg/l vs. 0.4 +/- 0.1 mg/l, respectively; P < 0.001). AS and AD were significantly lower in fluorosis patients than in the controls (for AS 5.3 +/- 3.6 vs. 8.0 +/- 3.4%; P < 0.001 and for AD 0.2 +/- 0.1 vs. 0.3 +/- 0.1 cm(2) dyn(-1) 10(-3); P < 0.001, respectively). In contrast, significantly higher ASI was observed in fluorosis patients than in the controls (3.4 +/- 0.6 vs. 3.0 +/- 0.4; P < 0.001, respectively). The results of our study demonstrate that elastic properties of ascending aorta are impaired in patients with endemic fluorosis.

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Section: Introductionmentioning

confidence: 99%

Aortic Elasticity is Impaired in Patients with Endemic Fluorosis

Varol

Akçay

Ersoy

et al. 2009

Biol Trace Elem Res

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“…Yüksek florid al›m›n-dan dolay› flehir halk›nda diflsel florozise s›k-ça rastlanmaktad›r (1,2). Buna ilaveten yap›-lan çal›flmalarda iskeletsel ve eklem deformiteleri de bildirilmifltir (3)(4)(5)(6). Endemik florozisin kemikte artan fliddette dejeneratif de¤ifliklik-lerden sorumlu oldu¤unu bildirmifllerdir (4-6).…”

Section: Discussionunclassified

“…Because of high fluoride intake, severe dental fluorosis is commonly encountered in the city (1,2). In addition, skeletal and joint deformities were also reported (3)(4)(5)(6). They implied that endemic fluorosis might be responsible for the increased severity of degenerative changes in the bone (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Dişsel Florozisi Olan Çocukların Yüz Gelişiminin Björk Analizi İle İncelenmesi

Doğan¹,

Bolpaça²

2008

Turkish Journal of Orthodontics

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“…Urine fluoride was analyzed by using an ion specific electrode (Orion Research, Inc.500 Cummings Center, Beverly, MA 01915-6199) (11). Spot urine fluoride level higher than 0.6 ppm was considered as elevated (1).…”

Section: Laboratory Analysesmentioning

confidence: 99%

Effects of fluorosis on QT dispersion, heart rate variability and echocardiographic parameters in children

Karademir¹,

Akçam²,

Kuybulu³

et al. 2011

Anadolu Kardiyol Derg

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ÖZETAmaç: Kronik flor zehirlenmesine florozis denilir. Bu çalışmanın amacı, çocuklardaki florozisin kardiyovasküler sistem üzerine olan etkilerini, QT dispersiyonu (QTd), düzeltilmiş QT dispersiyonu (QTcd), kalp hızı değişkenliği (KHD) ve ekokardiyografi (EKO) bulguları ile incelemektir. Yöntemler: Enine-kesitli bu araştırmada, dental florozisli 35, sağlıklı 26 çocuk çalışmaya alınmıştır. Klinik tanı Dean indeks kullanılarak konulmuştur. Spot idrarda flor seviyesi iyon elektrot metodu ile 0.6 ppm üzerinde ölçülen olgular çalışmaya alınmıştır. Serum elektrolit seviyeleri, tiroit fonksiyon testleri ölçülmüştür. Elektrokardiyografik, ekokardiyografik ve 24-saatlik ambulatuvar Holter monitorizasyonları uygulanmış ve tüm veriler KHD ölç-mek için değerlendirildi, QT ve QTcd aralıkları hesaplanmıştır. Düzeltilmiş QT aralığı Bazzett formülü ile belirlenmiştir. En uzun ve en kısa ölçümler arasındaki fark dispersiyon olarak adlandırılmıştır. Grupların karşılaştırılması Kruskal-Wallis testi ve Pearson korelasyon testi kullanılmıştır. Bulgular: Florozisi bulunan olgularda serbest T4 (ST4) (Kontrol Grup, Grup 2, 1.11 (0.85-1.64) ng/dL, 0.96 (0.85-1.11) ng/dL, sırasıyla, p<0.05) ve kalsiyum seviyelerinde (Kontrol Grup, Grup 1, Grup 2, 9.80, (9.30-10.70) mg/dL, 9.60, (8.90-10.70) mg/dL, 9.50, (8.90-10.10) mg/dL, p<0.05) azalma, serum sodyum değerlerinde artma (Kontrol Grup, Grup 2,(139)(140)(141)(142) ABSTRACTObjective: Chronic fluoride poisoning is called fluorosis. The aim of the study was to investigate effects of fluorosis on cardiovascular system in children by measuring QT dispersion (QTd), corrected QT dispersion (QTcd), heart rate variability (HRV) and echocardiography findings. Methods: Thirty-five children with dental fluorosis and 26 children as control group were included in this cross-sectional study. Dean index was used for the clinical diagnosis. The fluoride levels of subjects measured by ion electrode method in spot urine higher than 0.6 ppm were included in the study. Serum electrolytes and thyroid function tests were analyzed. Electrocardiography (ECG), echocardiography and 24-hour ambulatory Holter monitorizations were applied, and all the data were analyzed for measuring HRV, and calculation of QTd and QTcd intervals. Corrected QT (QTc) intervals were determined with the Bazzett formula. Difference between the longest and shortest intervals was considered as dispersion. Statistical analysis was performed Kruskal-Wallis test and Pearson correlation test. Results: Low free thyroxine hormone (FT4) (Control Group, Group 2 1.11 (0.85-1.64) ng/dL, 0.96 (0.85-1.11) ng/dL, p<0.05), calcium (Control Group, Group 1,2,) mg/dL, p<0.05) and high serum sodium levels (Control Group, Group 2 139 (136-142) mEq/L, 141 (138-148) mEq/L, p<0.01), increased QT (Control Group, Group 2 329.8 (300.0-363.5) msec, 351.8 (318.0-372.0) msec, p<0.05) and QTc intervals (Control Group,) msec, p<0.05) were found in subjects with fluorosis. No significant difference was found with respect to echocardiography and HRV variables. Conclusio...

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Endemic fluorosis in Turkish patients: relationship with knee osteoarthritis

Cited by 42 publications

References 19 publications

Aortic Elasticity is Impaired in Patients with Endemic Fluorosis

Aortic Elasticity is Impaired in Patients with Endemic Fluorosis

Dişsel Florozisi Olan Çocukların Yüz Gelişiminin Björk Analizi İle İncelenmesi

Effects of fluorosis on QT dispersion, heart rate variability and echocardiographic parameters in children

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