Endemic Burkitt lymphoma is associated with strength and diversity of Plasmodium falciparum malaria stage-specific antigen antibody response

Aka, Peter; Vila, Maria Candida; Jariwala, Amar; Nkrumah, Francis; Emmanuel, Benjamin; Yagi, Mamiko; Palacpac, Nirianne; Periago, María Victoria; Neequaye, Janet; Kiruthu, Christine; Tougan, Takahiro; Levine, Paul H.; Biggar, Robert J.; Pfeiffer, Ruth M.; Bhatia, Kishor; Horii, Toshihiro; Bethony, Jeffrey M.; Mbulaiteye, Sam M.

doi:10.1182/blood-2012-12-475665

Cited by 34 publications

(44 citation statements)

References 35 publications

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“…A cohort study conducted in the West Nile district in Uganda demonstrated elevated risk of eBL in children infected with EBV during infancy [3]. Several case-control studies have confirmed that children with high exposure to malaria, based on questionnaire and antibody measurements, have an elevated risk of eBL [4,5]. However, how these infections cause eBL is not well understood.…”

mentioning

confidence: 99%

Elevated serum levels of interleukin‐6 in endemic Burkitt lymphoma in Ghana

Aka¹,

Emmanuel²,

Vila

et al. 2014

Hematological Oncology

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mentioning

confidence: 99%

Elevated serum levels of interleukin‐6 in endemic Burkitt lymphoma in Ghana

Aka¹,

Emmanuel²,

Vila

et al. 2014

Hematological Oncology

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“…2 The ecological association between eBL and P. falciparum was shown in the 1970s, 1 but there is still limited evidence from studies examining this association at an individual level. [3][4][5][6][7][8] In 2012, the International Agency for Research on Cancer classified P. falciparum infection in holoendemic areas as "probably carcinogenic to humans." 9 A better description of eBL epidemiology is needed to enhance current understanding of the etiology of the disease.…”

mentioning

confidence: 99%

Incidence of Endemic Burkitt Lymphoma in Three Regions of Mozambique

O’Callaghan-Gordo

Casabonne

Carrilho

et al. 2016

The American Society of Tropical Medicine and Hygiene

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Abstract. Data on the burden and incidence of endemic Burkitt lymphoma (eBL) across Mozambique are scarce. We retrospectively retrieved information on eBL cases from reports of the three main hospitals of Mozambique: Maputo Central Hospital (MCH), Beira Central Hospital (BCH), and Nampula Central Hospital (NCH) between 2004 and 2014. For 2015, we prospectively collected information of new eBL cases attending these hospitals. A total of 512 eBL cases were reported between 2004 and 2015: 153 eBL cases were reported in MCH, 195 in BCH, and 164 in NCH. Mean age of cases was 6.9 years (standard deviation = 2.8); 63% (319/504) of cases were males. For 2015, the estimated incidence rate of eBL was 2.0, 1.7, and 3.9 per 10 6 person-year at risk in MCH, BCH, and NCH, respectively. Incidence was higher in NCH (northern Mozambique), where intensity of malaria transmission is higher. Data presented show that eBL is a common pediatric malignancy in Mozambique, as observed in neighboring countries.

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“…This form of leukemia accounts for only 1–2% of cases of childhood acute lymphoblastic leukemia. More commonly, patients with Burkitt's lymphoma present either as this child did, with a large abdominal mass and abdominal pain and distention, or with intussusception of the small bowel related to lymphoma involving the terminal ileum [5].…”

Section: Discussionmentioning

confidence: 94%

“…Burkitt's lymphoma is highly curable [5] and the majority of children with the disease are cured with relatively short courses of systemic multiagent chemotherapy. A risk-adapted treatment strategy is important in planning the intensity and duration of treatment for patients with Burkitt's lymphoma.…”

Section: Discussionmentioning

confidence: 99%