Endangered Saudi Arabian plants having ethnobotanical evidence as antidotes for scorpion envenoming

Alasmari, Abdulrahman; Abbasmanthiri, Rajamohamed; Osman, Nasreddien Mohammed Abdo; Al-Asmari, Byan Abdulrahman

doi:10.1186/s40816-020-00196-7

Cited by 3 publications

(3 citation statements)

References 42 publications

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“… [86] Al Asmari et al . also highlighted the protective effect of quercetin against hepato‐renal toxicity in rats induced by Echis coloratus snake venom, following an assessment of biochemical and histological changes [87] …”

Section: A Case For Natural‐product‐derived Small‐molecule Inhibitors Of Snake Venom Toxinsmentioning

confidence: 99%

Prospects and Challenges of Developing Plant‐Derived Snake Antivenin Natural Products: A Focus on West Africa

et al. 2021

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Snakebite envenomation (SBE) is an important public health issue that is now receiving renewed attention following its reclassification as a Neglected Tropical Disease (NTD). Most incidences occur in rural areas of resource‐limited countries, as such, timely and appropriate medical care for SBE is often inaccessible. The administration of anti‐snake venom serum (ASV) is the only effective definitive treatment of SBE, but treatment failure to available ASVs is not uncommon. Emerging evidence highlights the potential of small‐molecule compounds as inhibitors against toxins of snake venom. This presents an encouraging prospect to develop an alternative therapeutic option for the treatment SBE, that may be amenable for use at the point of care in resource‐constraint settings. In view of the pivotal role of natural products in modern drug discovery programmes, there is considerable interest in ethno‐pharmacological mining of medicinal plants and plant‐derived medicinal compounds toward developing novel snake venom‐neutralising therapeutics. In this review, we compile a collection of medicinal plants used in the treatment of SBE in West Africa and highlight their promise as potential botanical drugs or as sources of novel small‐molecule compounds for the treatment of SBE. The challenges that must be surmounted to bring this to fruition including the need for (sub) regional collaboration have been discussed.

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Section: A Case For Natural‐product‐derived Small‐molecule Inhibitors Of Snake Venom Toxinsmentioning

confidence: 99%

Prospects and Challenges of Developing Plant‐Derived Snake Antivenin Natural Products: A Focus on West Africa

et al. 2021

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“…The emerging commercial value of the phytochemical compounds from this plant species has prompted a surge in demand which causing increasing pressure on the plant density (Al-Asmari et al, 2020). Plant tissue culture techniques offer an efficient alternative in the propagation of valuable plant species for indepth study on plant response and the accumulation of natural secondary metabolites.…”

Section: Introductionmentioning

confidence: 99%

Effects of 2,4-Dichlorophenoxyacetic Acid on The Induction of Callus from Cotyledon and Hypocotyl Explants of Butterfly Pea (Clitoria ternatea)

Teoh

Subramaniam

Chew

2023

MAB

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Clitoria ternatea (Butterfly pea) is a tropical medicinal and fodder legume from the Fabaceae family possessing various beneficial phytochemical compounds linked to the mammalian neuroprotective mechanism. Callus and cell suspension cultures are excellent alternatives for harnessing secondary metabolites from medicinal plants. The current study aims to induce callus from cotyledon and hypocotyl explants of C. ternatea for the establishment of cell suspension cultures. Cotyledon and hypocotyl explants from two-weeks-old seedlings were subjected to half-strength MS medium supplemented with 2,4-dichlorophenoxyacetic acid (2,4-D) at different concentrations (0.5 mg/L to 2.5 mg/L) and callus scoring and morphology were assessed at week 8 of culture. Results revealed that the treatment of 0.5 mg/L 2,4-D resulted in the highest percentage of callus induction (100%) and the highest callus scoring for both cotyledon and hypocotyl explants with friable callus morphology. Cotyledon explants exhibited a higher callus scoring with a relative value of 3.03 ± 0.20 compared to hypocotyl explants at 1.80 ± 0.12. This study thereby provides a basis for future studies on callus induction studies and the establishment of cell suspension cultures of C. ternatea for the production of valuable secondary metabolites linked to the memory enhancing properties of the plant.

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“…For instance, a species is considered as endangered when one or more of its populations have declined, whereas a species becoming extinct is considered as rare [2]. Abrus Precatorius is one of the endangered plant species of the flora of Saudi Arabia [3,4]. In the Al Baha region of Saudi Arabia, Al-Khulaidi et al [2] noted that the frequency percentage and the density per hectare of Abrus Precatorius were 0.31 and 0.05, respectively.…”

Section: Introductionmentioning

confidence: 99%

Genome Estimation and Phytochemical Compound Identification in the Leaves and Callus of Abrus precatorius: A Locally Endangered Plant from the Flora of Saudi Arabia

Al‐Qurainy

Tarroum

Khan

et al. 2022

Plants

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Abrus precatorius is considered to be a valuable source of natural products for the development of drugs against various diseases. Herein, the genome size and phytochemical compounds in the leaves and callus of A. precatorius were evaluated. The endangered A. precatorius was collected from the Al-Baha mountains, Saudi Arabia and identified based on the phylogenetic analysis of a DNA sequence amplified by ITS1 and ITS4 primers. The callus was induced by the culture of stem explants onto Murashige and Skoog medium (MS) supplemented with various combinations of 2,4-dichlorophenoxyacetic acid (2,4D) and 6-Benzylaminopurine (BAP). The callus with the highest fresh weight (2.03 g) was obtained in the medium containing 0.5µM BA and 5 µM 2,4-D after 8 weeks of culture; thus, the callus of this combination was selected for the genome estimation and phytochemical compound extraction. The genetic stability of the leaves from the donor as well as in the regenerated callus was analyzed by flow cytometry with optimized tomato (2C = 1.96 pg) as an external reference standard. The 2C DNA content was estimated to 1.810 pg ± 0.008 and 1.813 pg ± 0.004 for the leaves and callus, respectively. Then, the total phenol and total flavonoid contents in the methanol extract of the callus and leaves were measured using a spectrophotometer and the High-performance liquid chromatography (HPLC ) methods. The results showed that the methanolic extract of the leaves was higher in total phenols and total flavonoids than the callus extract. Finally, the extracts of callus and leaves were analyzed for phytochemical compound through the Gas chromatography and Mass spectroscopy (GC-MS). A total of 22 and 28 compounds were detected in the callus and leaves, respectively. The comparative analysis showed that 12 compounds of the secondary metabolites were present in both extracts.

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Endangered Saudi Arabian plants having ethnobotanical evidence as antidotes for scorpion envenoming

Cited by 3 publications

References 42 publications

Prospects and Challenges of Developing Plant‐Derived Snake Antivenin Natural Products: A Focus on West Africa

Prospects and Challenges of Developing Plant‐Derived Snake Antivenin Natural Products: A Focus on West Africa

Effects of 2,4-Dichlorophenoxyacetic Acid on The Induction of Callus from Cotyledon and Hypocotyl Explants of Butterfly Pea (Clitoria ternatea)

Genome Estimation and Phytochemical Compound Identification in the Leaves and Callus of Abrus precatorius: A Locally Endangered Plant from the Flora of Saudi Arabia

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