End-Stage Renal Disease in 1528 Childhood-Onset Systemic Lupus Erythematosus Patients

Abstract

BACKGROUNDChildhood-onset systemic lupus erythematosus (cSLE) is a multisystemic inflammatory autoimmune disease, usually more severe than in adults, affecting major organs and systems, with different disease presentations, leading to increased morbidity and mortality rates. The study aimed to evaluate end-stage renal disease (ESRD) in a large sample of cSLE patients and to assess its association with clinical and laboratorial characteristics, disease activity, damage accrual, treatment, outcome, and survival. METHODSThis nationwide observational study was carried out in 27 Brazilian pediatric rheumatology centers, and includes 1528 cSLE patients. In this study, we also investigated cumulative risk factors for ESRD in cSLE patients.