End-stage renal disease after hypertensive disorders in pregnancy

Wu, Chia-Chun; Chen, Sheng-Hsien; Ho, Chung‐Han; Liang, Fu-Wen; Chu, Chin-Chen; Wang, Hsien-Yi; Lu, Yi-Hua

doi:10.1016/j.ajog.2013.09.027

Cited by 57 publications

(40 citation statements)

References 37 publications

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“…Patients with a history of pre-eclampsia were found to be at an eightfold increased risk for microalbuminuria 13. Recently, Wu et al 14 studied a database of 13 633 women with a maximum follow-up of 11 years and found 46 women with a diagnosis of end-stage renal disease. The authors found patients with a history of pre-eclampsia to be at 10 times greater risk for end-stage renal disease 14.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, Wu et al 14 studied a database of 13 633 women with a maximum follow-up of 11 years and found 46 women with a diagnosis of end-stage renal disease. The authors found patients with a history of pre-eclampsia to be at 10 times greater risk for end-stage renal disease 14. According to the results of our study, patients with a previous diagnosis of pre-eclampsia were at a higher risk for renal-related hospitalisations even after controlling for maternal age and other confounders known to be related to the metabolic syndrome.…”

Section: Discussionmentioning

confidence: 99%

“…Data regarding the link between pre-eclampsia and future risk for renal morbidity are not that well established 13 14. Also, it is not clear whether a ‘dose–response’ association exists between the severity of the condition and the number of episodes of pre-eclampsia and the risk for CVD and renal morbidity later in the non-pregnant life.…”

Section: Introductionmentioning

confidence: 99%

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Long-term maternal atherosclerotic morbidity in women with pre-eclampsia

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Long-term maternal atherosclerotic morbidity in women with pre-eclampsia

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et al. 2015

Heart

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“…This risk triples when women had PE during more than one pregnancy or a pregnancy complicated by low-birthweight or preterm delivery [31]. Two Taiwanese cohort studies (with overlap) found hazard ratio (HR) of between 10.6 and 14.0 for developing ESRD after PE [4,5]. Although RRs are high, the absolute risk for ESRD in formerly preeclamptic patients remains quite low with an incidence of only 14.5/100.000 person years [31].…”

Section: Premature Cvd and Esrd After Preeclampsiamentioning

confidence: 96%

“…This increased risk of CVD is accompanied by disturbances in renal function [2,3]. In the past 5-10 years, it has also been shown that women with a history of PE have an approximate 5-12-fold increased risk of developing end-stage renal disease (ESRD) in later life [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Long-term renal and cardiovascular risk after preeclampsia: towards screening and prevention

et al. 2016

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Preeclampsia (PE) is a hypertensive pregnancy disorder complicating up to 1-5% of pregnancies, and a major cause of maternal and fetal morbidity and mortality. In recent years, observational studies have consistently shown that PE carries an increased risk for the mother to develop cardiovascular and renal disease later in life. Women with a history of PE experience a 2-fold increased risk of long-term cardiovascular disease (CVD) and an approximate 5-12-fold increased risk of end-stage renal disease (ESRD). Recognition of PE as a risk factor for renal disease and CVD allows identification of a young population of women at high risk of developing of cardiovascular and renal disease. For this reason, current guidelines recommend cardiovascular screening and treatment for formerly preeclamptic women. However, these recommendations are based on low levels of evidence due to a lack of studies on screening and prevention in formerly preeclamptic women. This review lists the incidence of premature CVD and ESRD observed after PE and outlines observed abnormalities that might contribute to the increased CVD risk with a focus on kidney-related disturbances. We discuss gaps in current knowledge to guide optimal screening and prevention strategies. We emphasize the need for research on mechanisms of late disease manifestations, and on effective screening and therapeutic strategies aimed at reducing the late disease burden in formerly preeclamptic women.

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Adverse Pregnancy Outcomes and Long-term Maternal Kidney Disease

et al. 2020

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IMPORTANCE Adverse pregnancy outcomes, such as hypertensive disorders of pregnancy, gestational diabetes, and preterm delivery, are associated with increased risk of maternal cardiovascular disease. Little is known about whether adverse pregnancy outcomes are associated with increased risk of maternal chronic kidney disease (CKD) and end-stage kidney disease (ESKD). OBJECTIVE To review and synthesize the published literature on adverse pregnancy outcomes (hypertensive disorders of pregnancy, gestational diabetes, and preterm delivery) and subsequent maternal CKD and ESKD. DATA SOURCES PubMed, Embase, and Web of Science were searched from inception to July 31, 2019, for cohort and case-control studies of adverse pregnancy outcomes and maternal CKD and ESKD. STUDY SELECTION Selected studies included the following: a population of pregnant women, exposure to an adverse pregnancy outcome of interest, and at least 1 primary outcome (CKD or ESKD) or secondary outcome (hospitalization or death due to kidney disease). Adverse pregnancy outcomes included exposure to hypertensive disorders of pregnancy (preeclampsia, gestational hypertension, or chronic hypertension), preterm delivery (<37 weeks), and gestational diabetes. Three reviewers were involved in study selection. Of 5656 studies retrieved, 23 were eligible for inclusion. DATA EXTRACTION AND SYNTHESIS The Meta-analyses of Observational Studies in Epidemiology (MOOSE) guidelines were followed throughout. Three reviewers extracted data and appraised study quality. Random-effects meta-analyses were used to calculate overall pooled estimates using the generic inverse variance method. MAIN OUTCOMES AND MEASURES Primary outcomes included CKD and ESKD diagnosis, defined using established clinical criteria (estimated glomerular filtration rate or albuminuria values) or hospital records. The protocol for this systematic review was registered on PROSPERO (CRD42018110891). RESULTS Of 23 studies included (5 769 891 participants), 5 studies reported effect estimates for more than 1 adverse pregnancy outcome. Preeclampsia was associated with significantly increased risk of CKD (pooled adjusted risk ratio [aRR], 2.11; 95% CI, 1.72-2.59), ESKD (aRR, 4.90; 95% CI, 3.56-6.74), and kidney-related hospitalization (aRR, 2.65; 95% CI, 1.03-6.77). Gestational hypertension was associated with increased risk of CKD (aRR, 1.49; 95% CI, 1.11-2.01) and ESKD (aRR, 3.64; 95% CI, 2.34-5.66). Preterm preeclampsia was associated with increased risk of ESKD (aRR, 5.66; 95% CI, 3.06-10.48); this association with ESKD persisted for women who had preterm (continued) Key Points Question Are adverse pregnancy outcomes associated with risk of longterm kidney disease in women? Findings In this systematic review and meta-analysis of 23 studies (5 769 891 participants), the risk of end-stage kidney disease was 4.9 times higher in women who had preeclampsia, and 3.6 times higher in women who had gestational hypertension vs women with normotensive pregnancies. The risk of end-stage kidney disease was 2.1 time...

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End-stage renal disease after hypertensive disorders in pregnancy

Cited by 57 publications

References 37 publications

Long-term maternal atherosclerotic morbidity in women with pre-eclampsia

Long-term maternal atherosclerotic morbidity in women with pre-eclampsia

Long-term renal and cardiovascular risk after preeclampsia: towards screening and prevention

Adverse Pregnancy Outcomes and Long-term Maternal Kidney Disease

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