End Results in the Irradiation of Primary Carcinoma of the Vagina

Primary invasive carcinoma of the vagina

“…Data from early primary vaginal carcinoma series containing at least 40 patients from 1929 through the 1960s have been recorded in Table 1. 9,[11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] Five-year survival rates of 20 -30% for all stages generally were achieved. Among the higher cure rates are Felix Noah Rutledge's series of 43 women who were treated at the M. D. Anderson Hospital and Tumor Institute in Houston (5-year survival rate, 35%) 27 and Dunn and Napier's account of 40 patients who were treated at the University of Iowa Hospitals (5-year survival rate, 42.5%).…”

“…For example, in 1979, Pride et al 41 observed that the survival rate from invasive squamous cell carcinoma of the vagina had improved significantly over the past 25 years and suggested that this was due to the widespread use of interstitial irradiation of the local vaginal tumor and administration of supravoltage radiation. These ideas are best observed when comparing the crude survival rates from reports of patients who were treated predominantly during the first half of the 20th century (20 -30% 5-year survivorship for all stages; Table 1) 9,[11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] with patients who were treated during the latter half of the 20 th century (the two-to five-year survivorship for patients with Stage II-III disease was 30 -70%; Table 7). [41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56] Series selected for tabulation in the latter table were those in which a minimum of 25 patients had been treated with radiotherapy for primary vaginal carcinoma (data from the current study are entered on the last line of Table 7).…”

Primary Malignant Melanoma of the Vagina

“…Radiotherapy appears to be the most common form of treatment for squamous cell carcinoma of the vagina and results vary from 19% 5-year survival for advanced lesions up to 66.7% survival (3-12 years) for 'early' cases [4], Murphy and Bozzini [18] reported 5-year survival rates of 20-59% for advanced and early lesions, respectively, in a series of cases treated with radiotherapy from 1940 to 1955. Perez et al [22] reported absolute 5-year cure rates of 75% using radiotherapy for in situ and invasive lesions confined to the vaginal mucosa.…”

Malignant tumors of the vagina

“…8 It became evident, however, that the prognosis was the same in both groups, and, for this reason, all Stage I patients have been consolidated into one group. It was also apparent that tumors with parametrial induration had a distinctly more aggressive clinical behavior than those with paravaginal submucosal ex- [15][16][17][18][19]23 No. 1 TUMORS OF THE VAGINA * Perez et al tension only.…”