End-point determination of heterogeneous formulations using inline torque measurements for a high-shear wet granulation process

Dan, Ashley; Vaswani, Haresh; Šimonová, Alice; Grząbka-Zasadzińska, Aleksandra; Li, Jingzhe; Sen, Koyel; Paul, Shubhajit; Tseng, Yin-Chao; Ramachandran, Rohit

doi:10.1016/j.ijpx.2023.100188

Cited by 2 publications

(2 citation statements)

References 33 publications

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“…Since torque has been shown to be correlated to granule quality attributes, such as particle size and porosity, 17,18 the goal of this work is to optimize the energy efficiency of the TSG process while maintaining the critical quality attributes of the granules.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Thus, it becomes vital to reduce the amount of torque required by the system by manipulating the process parameters in an effort to optimize the energy efficiency of the TSG process in real-time, thereby aiding sustainability efforts. Since torque has been shown to be correlated to granule quality attributes, such as particle size and porosity, , the goal of this work is to optimize the energy efficiency of the TSG process while maintaining the critical quality attributes of the granules.…”

Section: Introductionmentioning

confidence: 99%

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Optimizing Energy Efficiency of a Twin-Screw Granulation Process in Real-Time Using a Long Short-Term Memory (LSTM) Network

Sampat,

Ramachandran

2023

ACS Eng. Au

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Traditional pharmaceutical manufacturing processes for solid oral dosage forms can be inefficient and have been known to produce a large amount of undesired product. With the progressing trend of achieving carbon neutrality, there is an impetus to increase the energy efficiency of these manufacturing processes while maintaining the critical quality attributes of the product. One of the important steps in downstream pharmaceutical manufacturing is wet granulation, and within that, twin screw granulation (TSG) is a popular continuous manufacturing technique. In this study, the energy efficiency of the TSG process was maximized by combining a long-term memory (LSTM) model with an optimization algorithm. The LSTM model was trained on time-series process data obtained from the TSG experimental runs. The optimization process, with the objective of maximizing energy efficiency, was performed using a stochastic optimization algorithm, and constraints were enforced on the process parameter design space. Experimental runs at the optimal process parameters were conducted on the TSG equipment with updates occurring at predefined intervals depending on the optimization scenarios. The purpose of these experimental runs was to validate the capability of increasing the overall process energy efficiency when operating at the optimized process parameters. A maximum increase of 27% was obtained between two tested optimization scenarios while maintaining the yield of the granules at the end of the twin-screw granulation process.

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Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Optimizing Energy Efficiency of a Twin-Screw Granulation Process in Real-Time Using a Long Short-Term Memory (LSTM) Network

Sampat,

Ramachandran

2023

ACS Eng. Au

Self Cite

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ORBIS project – where have we arrived?

Skotnicki,

Jakubowska,

Smułek

et al. 2023

JMS

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The Open Research Biopharmaceutical Internships Support project (ORBIS) was a response to the scientific, economic, and social challenge of increasing the effectiveness and productivity of the drug development process, both for innovative and (super)generic drugs. The overarching objective of the ORBIS project was to form a transnational and intersectoral cooperation network of academic and industrial organisations delivering a joint research programme. The research aimed at improving the preclinical pathway of drug development and manufacturing, focusing on technological and methodological improvements of the existing processes. The participating staff from all institutions have developed new skills, were exposed to new work and research environments, and have significantly broadened their career perspectives. More than 450 months of secondments were completed, and over 175 early-stage and experienced researchers participated in the exchange. This review aims to present some aspects of the scientific, training, and organisational activities of the consortium, bringing together representatives of both the academic sector as well as small and medium-sized pharmaceutical enterprises.

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End-point determination of heterogeneous formulations using inline torque measurements for a high-shear wet granulation process

Cited by 2 publications

References 33 publications

Optimizing Energy Efficiency of a Twin-Screw Granulation Process in Real-Time Using a Long Short-Term Memory (LSTM) Network

Optimizing Energy Efficiency of a Twin-Screw Granulation Process in Real-Time Using a Long Short-Term Memory (LSTM) Network

ORBIS project – where have we arrived?

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