Clinical approach of palliative care is beneficial during an individual's journey with illness, and can be utilized through many care settings by all members of the health care team. Many complex cultural issues can affect the patient and the families during the course of a life-threatening illness. Palliative care services in all countries need to be delivered in a way that meets the cultural and spiritual needs of its people. Insuring the availability of palliative care has become an increasingly important global health priority in recent years. As population age and the prevalence of chronic illnesses increases in emerging countries, as in all other countries worldwide, the need for palliative care has risen significantly. The World Health Organization (WHO) estimates that more than 40 million people require palliative care annually at the end-of-life.One of the challenges of palliative care is to honour the personal wishes of culturally diverse patients while meeting universal medical relief standards. Palliative care begins with the understanding that every patient has his/her own story, relationships and culture, and is worthy of respect as a unique individual.Culture refers to common elements or characteristics within one's sociological grouping. Different values, beliefs, behaviours, languages, rituals, customs or traditions, and accepted practices for living and dying, partnering, marriage, childbearing, parenting, and family communal life creates cultural groupings. Culture can include elements such as developmental stage of life, profession, and educational level, geographic region of the country, religion, spirituality, sexual orientation, political affiliation, gender, socioeconomic status, and more.Palliative care is a relatively new concept in many countries in the developing world. Health professionals and whole populations are unaware of palliative care. Health care is not only providing cures, also improving the quality of life of patients and patient's families. Palliative care is applicable during the onset of life-threatening illness. A common misconception is that only terminal ill cancer patients are in need of palliative care. By contrast, the hospice and palliative care movement has been providing increasing awareness of various end-of-life issues. End-of-life care means more than treating physical symptoms -it extends to the psychosocial, existential, and spiritual aspects of the patient's needs, including developing trust in the substantial care of the patient and the family during this time. Numerous studies aimed to understand the relevance of culture to death and dying and found that communication was the greatest barrier between the health-care provider and the patient and family during end-of-life care.