Encoding extracellular modification of artificial cell membranes using engineered self-translocating proteins
Alexander Harjung,
Alessandro Fracassi,
Neal Devaraj
Abstract:A common method of generating artificial cells is to encapsulate protein expression systems within lipid vesicles. However, to communicate with the external environment, protein translocation across lipid membranes must take place. In living cells, protein transport across membranes is achieved with the aid of complex translocase systems which are difficult to reconstitute into artificial cells. Thus, there is need for simple mechanisms by which proteins can be encoded and expressed inside synthetic compartmen… Show more
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