Molecular Cell
 2006
DOI: 10.1016/j.molcel.2006.03.002
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Encircled: Large-Scale Purification of Replication Origins from Mammalian Chromosomes

Anja‐Katrin Bielinsky
1
,
Miruthubashini Raveendranathan
2

Abstract: A novel cloning strategy for sequences comprising mammalian replication origins, described by Mesner et al. (2006) in a recent issue of Molecular Cell, utilizes an origin trapping assay in which replication bubbles are selectively retained in agarose due to their circular nature.

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