Enchondroma versus chondrosarcoma in the appendicular skeleton: differentiating features.

Murphey, Mark D.; Flemming, Donald J.; Boyea, S.; Bojescul, John A.; Sweet, Donald E.; Temple, H. Thomas

doi:10.1148/radiographics.18.5.9747616

Cited by 334 publications

(288 citation statements)

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“…We also included patients with more than 5 years of followup. A couple published reports of patients affected by CS include various locations of bone involvement, tumor grades, and followup times [17,19].…”

Section: Discussionmentioning

confidence: 99%

“…For this reason, it is particularly important to combine the radiographic interpretation with the histologic finding. Nevertheless, histologic grade is a good prognostic factor [3,16,17,19].…”

Section: Introductionmentioning

confidence: 99%

“…Standard radiography often is sufficient to assess the extent of the tumor in the medullary canal and its relation with the cortex [5,9,14,15]. CT [24] and MRI can show whether there is endosteal involvement or breakthrough in the cortex [4,11,17]. The radiographic and histologic elements that allow clear distinction between enchondroma and Grade I central CS remain controversial.…”

Section: Introductionmentioning

confidence: 99%

“…Although enchondroma can be treated by curettage, or in case of inactive lesions, even nonsurgically [6], Grade I CS usually is treated with en bloc resection with wide margins. The adequacy of intralesional surgery is advocated by some surgeons [2,13] and opposed by others [17][18][19]23].…”

Section: Introductionmentioning

confidence: 99%

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Surgical Treatment of Grade I Central Chondrosarcoma

Donati

Colangeli

et al. 2010

Clinical Orthopaedics &Amp; Related Research

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The grade of chondrosarcoma relates to the likelihood of local recurrence and metastases. Many Grade I chondrosarcomas behave benignly if aggressively, and the question arises regarding whether wide resection is essential to control the disease. We therefore asked whether intralesional surgery also could be extended to Grade I chondrosarcomas without an increase in recurrence. We retrospectively reviewed 31 patients with Grade I chondrosarcomas of the limbs. The minimum followup was 66 months (mean, 157 months; range, 66-296 months

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Surgical Treatment of Grade I Central Chondrosarcoma

Donati

Colangeli

et al. 2010

Clinical Orthopaedics &Amp; Related Research

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“…In a retrospective study, Murphey et al found the presence of foci of hypersignal within lesions on T1-weighted images of enchondromas and low-grade chondrosarcomas, and have correlated such MRI image with histopathological findings (17) .…”

Section: Introductionmentioning

confidence: 99%

Incidental enchondromas at knee magnetic resonance imaging: intraobserver and interobserver agreement and prevalence of imaging findings

et al. 2013

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Objective: To evaluate intra-and interobserver agreement in the identification of incidental enchondromas at knee magnetic resonance imaging, and to assess the prevalence of imaging findings. Materials and Methods: Retrospective study reviewing 326 knee magnetic resonance images acquired in the period between November 2009 and September 2010. The images were independently and blindly analyzed by two specialists in musculoskeletal radiology, with the objective of identifying incidental enchondromas, presence of foci with signal similar to bone marrow and foci of signal absence suggestive of calcifications within the enchondromas. Inter-and intraobserver agreements were analyzed. Results: Eleven lesions compatible with enchondromas (3.3%) were identified. The interobserver agreement for the presence of enchondroma was high. Prevalence of foci of bone marrow signal inside the enchondromas was of 54.55%, and foci suggestive of calcification corresponded to 36.36%. The intraobserver agreement for foci of bone marrow signal in enchondromas was perfect, and interobserver agreement was high. Conclusion: The prevalence of incidental enchondromas in the current study was compatible with data in the literature. Excellent agreement was observed in the identification of enchondromas and in the assessment of imaging findings. A higher prevalence of fat signal foci was observed as compared with signal absence suggestive of calcifications. Keywords: Enchondromas; Magnetic resonance imaging; Knee; Bone marrow.Objetivo: Avaliar a confiabilidade intra e interobservador na identificação de encondromas incidentais na ressonância magnética de joelho e estudar a prevalência das características de imagens destas lesões. Materiais e Métodos: Estudo retrospectivo, com revisão de 326 ressonâncias magnéticas do joelho realizadas entre novembro de 2009 e setembro de 2010. As imagens foram analisadas por dois médicos especialistas em radiologia musculoesquelética, de forma independente e às cegas, visando a identificar encondromas incidentais, presença de focos com sinal semelhante à medula óssea e focos de ausência de sinal sugestivos de calcificações no interior dos encondromas. Foram realizadas análises das concordâncias inter e intraobservador. Resultados: Foram identificadas 11 lesões compatíveis com encondromas (3,3%). A concordância interobservador para presença de encondroma foi alta. A prevalência de focos de sinal de medula óssea no interior dos encondromas foi 54,55% e de focos sugestivos de calcificação foi 36,36%. A concordância intraobservador para focos de sinal de medula óssea nos encondromas foi perfeita, e a concordância interobservador foi alta. Conclusão: A prevalência de encondromas incidentais no trabalho atual foi consistente com a literatura. Foi observada excelente concordância no estudo de confiabilidade da identificação de encondromas e de suas características, notando-se maior prevalência de focos com sinal de gordura do que de calcificações. Unitermos: Encondromas; Ressonância magnética; Joelho; Medula óssea. Ab...

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Familial solitary chondrosarcoma resulting from germline EXT2 mutation

Heddar

Fermey

Coutant

et al. 2016

Genes Chromosomes & Cancer

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Germline mutations of EXT2, encoding Exostosin Glycosyltransferase 2, are associated with multiple osteochondromas (MO), an autosomal dominant disease characterized by the development of multiple peripheral cartilaginous benign tumors with a weak risk of malignant transformation. We report here a family with a remarkable clinical presentation characterized by the development of isolated chondrosarcomas, mostly located in ribs. Comparative analysis of exomes from two third-degree affected relatives led us to identify a single common disruptive variation, corresponding to a stop mutation (c.237G > A, p.Trp79*; (NM_000401.3); c.138G > A, p.Trp46*; (NM_207122.1)) within exon 2 of the EXT2 gene. Interestingly, no obvious sign of MO was detected in affected members by radiological examination. This report shows that germline mutations of EXT2 can result, not only in the development of multiple benign osteochondromas, but also in the development of isolated malignant cartilaginous tumors including central tumors, and that the presence of germline EXT2 mutation should be considered in patients suspected to have an inherited predisposition to chondrosarcoma, even in the absence of MO. © 2016 Wiley Periodicals, Inc.

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Enchondroma versus chondrosarcoma in the appendicular skeleton: differentiating features.

Cited by 334 publications

References 0 publications

Surgical Treatment of Grade I Central Chondrosarcoma

Surgical Treatment of Grade I Central Chondrosarcoma

Incidental enchondromas at knee magnetic resonance imaging: intraobserver and interobserver agreement and prevalence of imaging findings

Familial solitary chondrosarcoma resulting from germline EXT2 mutation

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