Encephalopathy with a reversible splenial lesion is associated with hyponatremia

Takanashi, Jun‐ichi; Tada, Hayato; Maeda, Masayuki; Suzuki, Michitaka; Terada, Hitoshi; Barkovich, A. James

doi:10.1016/j.braindev.2008.04.002

Cited by 127 publications

(119 citation statements)

References 14 publications

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“…3 It has also been reported in some cases of mild encephalitis/encephalopathy caused by various agents, such as influenza, mumps, rotavirus, adenovirus, human herpesvirus-6, measles virus, Escherichia coli, streptococcus, Salmonella enteritidis, Legionella, Hyponatremia, antiepileptic drug, and acute urinary retention. [1][2][3][4][5][6][7] To our knowledge, this is the first report of a patient with MERS detected on a brain MRI who did not present with any central nervous system disturbances.…”

Section: Introductionmentioning

confidence: 70%

Clinically Mild Encephalitis/Encephalopathy with a Reversible Splenial Lesion without Central Nervous System Disturbances: A Case Report

Tetsuka

Ogawa

2016

J of Gen and Family Med

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Patients with clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) on the splenium of the corpus callosum (SCC) present with relatively mild central nervous system disturbances. A 41-year-old man was admitted with fever and headache and, his main symptoms were mild headache and fatigue. There were no neurological focal signs. Brain magnetic resonance imaging (MRI) showed abnormal signals in SCC. We report, for the first time, a MERS patient, detected on MRI, who did not present with central nervous system disturbances. Our experience suggests MERS should be considered as a differential diagnosis in patients with fever of unknown origin.

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Section: Introductionmentioning

confidence: 70%

Clinically Mild Encephalitis/Encephalopathy with a Reversible Splenial Lesion without Central Nervous System Disturbances: A Case Report

Tetsuka

Ogawa

2016

J of Gen and Family Med

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“…ADC may return to normal within a week if the intramyelinic edema or inflammatory infiltrate resolves quickly. Takanashi et al [21] reported that most patients with MERS had mild hyponatremia with a mean serum sodium level (131.0 ± 4.1 mmol/L) lower than that of the healthy group. Our review revealed that 6/16 MERS patients had hyponatremia upon admission.…”

Section: Discussionmentioning

confidence: 98%

Reversible Splenial Lesion associated with Cellulitis in a Patient with Lymphedema

Son¹,

Lee²,

Lee³

et al. 2017

J Neurocrit Care

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Background: Mild encephalitis/encephalopathy with reversible splenial lesion (MERS) is a rare clinico-radiological entity characterized by the magnetic resonance imaging (MRI) finding of a reversible lesion in the corpus callosum, sometimes involved the symmetrical white matters. Many cases of child-onset MERS with various causes have been reported. However, adult-onset MERS is relatively rare. The clinical characteristics and pathophysiologiccal mechanisms of adult-onset MERS are not well understood. We reviewed the literature on adult-onset MERS in order to describe the characteristics of MERS in adults and to provide experiences for clinician. Methods: We reported a case of adult-onset MERS with acute urinary retension and performed literature search from PubMed and web of science databases to identify other adult-onset MERS reports from Januarary 2004 to March 2016. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline was followed on selection process. And then we summarized the clinico-radiological features of adult-onset MERS. Results: Twenty-nine adult-onset MERS cases were reviewed from available literature including the case we have. 86. 2% of the cases (25/29) were reported in Asia, especially in Japan. Ages varied between 18 and 59 years old with a 12: 17 female-to-male ratio. The major cause was infection by virus or bacteria. Fever and headache were the most common clinical manifestation, and acute urinary retention was observed in 6 patients. All patients recovered completely within a month. Conclusion: Adult-onset MERS is an entity with a broad clinico-radiological spectrum because of the various diseases and conditions. There are similar characteristics between MERS in adults and children, also some differences.

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“…First reports described this rare entity in patients who had seizures with secondary generalization (5) and in patients with toxicity or drug sensitivity to antiepileptic (6). Subsequently, this entity has widened its spectrum and has been associated with diff erent clinical neurologic and nonneurologic conditions, including postinfectious disorder (7), rapid withdrawal of antiepileptic drugs (8), high-altitude cerebral edema (9), and various metabolic disorders (hypoglycemia and hypernatremia) (10). Due to the heterogeneous entities linked to mild encephalitis/encephalopathy with reversible splenial and white matter (12), alteration of the arginine-vasopressin system which may aff ect brain hydric content (13), and development of an infl ammatory infi ltrate with infl ux of infl ammatory cells and molecules possibly combined with related cytotoxic edema (14).…”

Section: Discussionmentioning

confidence: 99%

Leukoencephalopathic Changes on Magnetic Resonance Imaging Associated with a Thermogenic Dietary Supplement (Thermatrim)

Treviño-Garcia

Chua-Tuan

Rodriguez-Cordero³

et al. 2015

Baylor University Medical Center Proceedings

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Encephalopathy with a reversible splenial lesion is associated with hyponatremia

Cited by 127 publications

References 14 publications

Clinically Mild Encephalitis/Encephalopathy with a Reversible Splenial Lesion without Central Nervous System Disturbances: A Case Report

Clinically Mild Encephalitis/Encephalopathy with a Reversible Splenial Lesion without Central Nervous System Disturbances: A Case Report

Reversible Splenial Lesion associated with Cellulitis in a Patient with Lymphedema

Leukoencephalopathic Changes on Magnetic Resonance Imaging Associated with a Thermogenic Dietary Supplement (Thermatrim)

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