Encephalopathy caused by visceral larva migrans due to Ascaris suum

Inatomi, Yuichiro; Murakami, Tatsufumi; Tokunaga, Makoto; Ishiwata, Kenji; Nawa, Yukifumi; Uchino, Makoto

doi:10.1016/s0022-510x(99)00078-7

Cited by 44 publications

(25 citation statements)

References 9 publications

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“…It should be marked that incorrectly hygienized sewage deposits and composts (pasteurization, liming) play significant role in epidemiological chain invasions by geohelminthes in people and animals. Numerous cases of invasions caused by Ascaris suum and Trichuris suis in people were noted in spite of the fact that man is only an accidental host for them (Inatomi et al, 1999;Kakahara et al, 2004;Nejsum et al, 2005). In our study, in compost samples from Bechcice and Borkowice dead eggs and larvae of Strongyloides ransomi were detected.…”

Section: Discussioncontrasting

confidence: 44%

Contamination of the soil by eggs of geohelminths in rural areas of Lodz district (Poland)

Błaszkowska

Kurnatowski

Damiecka³

2011

Helminthologia

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SummaryContamination of soil with helminth eggs in the samples of fields, kitchen gardens, yards and composts in rural areas of Lodz district (Poland) was investigated. In this study, helminth eggs were found in 60 -100 % of field samples, in 20 -100 % of yards samples, in 0 -20 % of kitchen gardens samples and in 10 -100 % of composts. The highest average density of helminth eggs in 100 g of soil was detected in composts (44.0), then fields (28.5) and yards (18.0). In samples taken from kitchen gardens the average density of eggs was 0.4/100/g of soil. The comparison of frequency of positive samples from fields, kitchen gardens and yards did not exhibit significant difference (p > 0.05). The soil samples of fields contained mainly eggs of Ascaris spp. (87.7 %), less frequently Toxocara spp. (7.7 %) and Trichuris spp. (3.5 %). In samples from yards among detected eggs the most often were Toxocara spp. (73.9 %), and there were statistically significant differences in comparison with fields (7.7 %) and composts (0.3 %). The highest prevalence of eggs with moving larva was noted in yards (25.6 %), which differ statistically significantly from analogous value for fields (p < 0.05) and composts (p < 0.0001). These results showed a considerable infestation of soil with geohelminth eggs of the examined rural areas of Lodz district which is a potential source of antropozoonosis.

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Section: Discussioncontrasting

confidence: 44%

Contamination of the soil by eggs of geohelminths in rural areas of Lodz district (Poland)

Błaszkowska

Kurnatowski

Damiecka³

2011

Helminthologia

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“…Reactivity of recombinant As16 with sera from rabbits, mice, and pigs repeatedly infected with A. suum (lanes 1 to 6) (20,32,55). A number of attempts have been made to characterize the two species for diagnostic purposes but with little success (29,33,38).…”

Section: Figmentioning

confidence: 99%

Mice Intranasally Immunized with a Recombinant 16-Kilodalton Antigen from RoundwormAscarisParasites Are Protected against Larval Migration ofAscaris suum

et al. 2003

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Protective immunity to the pig roundworm, Ascaris suum, has been demonstrated by immunization of pigs with antigens derived from the parasite's larval stages. We identified a protective antigen commonly expressed in the human and pig Ascaris infections as a 16-kDa protein (As16), which has no similarity at the amino acid level to mammalian proteins but has some similarity to those of the filarial parasites and Caenorhabditis elegans gene product. Localization analysis revealed that the native As16 was highly expressed in the adult worm intestine, hypodermis, and cuticles. In addition, As16 was detected in the parasite excretory and secretory products. Mice intranasally vaccinated with Escherichia coli-expressed recombinant As16 (rAs16), coupled with cholera toxin B subunit, generated a significant increase in the level of rAs16-specific immunoglobulin G (IgG) and IgE in serum. Mucosal IgA levels were also increased. The recombinant protein evoked a mixed (both Th1 and Th2) type of immune response characterized by elevated levels of gamma interferon and interleukin-10 in the culture supernatants of activated spleen cells. An increased level of IgG1 and IgG2a in serum was also observed. The vaccinated mice showed a reduction by 58% in the recovery of challenged larvae compared to a nonvaccinated control. These results suggest the possibility of developing a mucosal vaccine for human and pig ascariasis.

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“…Humans or pigs can be infected with either of the two species (Crompton 2001) and various pathological abnormalities in humans are reportedly associated with A. suum infections (Maruyama et al 1996;Takeyama et al 1997;Inatomi et al 1999). A number of attempts have been made to characterize the two species of parasites on a morphological, immunological or biochemical basis, but with little success (Maung 1973;Kurimoto 1974;Nadler 1987).…”

Section: Introductionmentioning

confidence: 99%

Species-specific proteins identified in Ascaris lumbricoides and Ascaris suum using two-dimensional electrophoresis

Wossene

Tsuji

Kasuga-Aoki

et al. 2002

Parasitology Research

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The protein profile of adult female Ascaris lumbricoides and Ascaris suum originating from humans and pigs, respectively, was studied using two-dimensional polyacrylamide gel electrophoresis. Six different major protein spots specific for A. lumbricoides were identified irrespective of their geographical origin and no major specific spot was encountered in A. suum. No major differences in the protein profiles between the extract by phosphate-buffered saline and urea were encountered for either Ascaris species. It is therefore possible to use 2D-PAGE as a tool for discriminating the closely related Ascaris species from humans and pigs.

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Encephalopathy caused by visceral larva migrans due to Ascaris suum

Cited by 44 publications

References 9 publications

Contamination of the soil by eggs of geohelminths in rural areas of Lodz district (Poland)

Contamination of the soil by eggs of geohelminths in rural areas of Lodz district (Poland)

Mice Intranasally Immunized with a Recombinant 16-Kilodalton Antigen from RoundwormAscarisParasites Are Protected against Larval Migration ofAscaris suum

Species-specific proteins identified in Ascaris lumbricoides and Ascaris suum using two-dimensional electrophoresis

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