“…Recently, however, hundreds of cases of encephalopathy associated with influenza have been reported in Japan. 6,21,[23][24][25] In these series, a subset of patients (both children and adults) developed a newly described entity termed "acute necrotizing encephalopathy" (ANE). 14,23,26,27 Many patients with this syndrome present with high fever, seizures, and alterations in mental status that rapidly progress to coma.…”