Encéphalopathie hépatique minime : un diagnostic précoce pour améliorer le pronostic

Ennaifer, Rym; Cheikh, M. Ben; Hefaiedh, Rania; Hayfa, Romdhane; Hadj, Najet Bel

doi:10.1016/j.lpm.2013.09.016

Cited by 6 publications

(3 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Li et al found that the higher the Child score, the higher the number of cases of MHE [9]. Ennaifer et al found a MELD score ≥ 15 as the only independent variable associated with the onset of MHE [13]. However, we noticed that more than half of patients with MHE was Child Pugh A in the group of patients with MHE.…”

Section: Discussioncontrasting

confidence: 51%

See 1 more Smart Citation

Normalization of the Psychometric Encephalopathy Score in Cameroonian Population

Djomatcho

Kowo

Ndam

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Minimal hepatic encephalopathy (MHE) is the presence of neuropsychological abnormalities detectable by psychometric tests. Psychometric Hepatic Encephalopathy Score (PHES) is a gold standard test for the early diagnosis of MHE in cirrhotic patients. Aim: To standardize the PHES in a healthy Cameroonian population and to evaluate the prevalence of MHE among cirrhotic patients. Methods: This was a prospective, multicentric study from December 1st, 2018 to July 31st, 2019 in two groups: healthy volunteers and cirrhotic patients without clinical signs of hepatic encephalopathy. The results of the Number Connection Test-A (NCT-A), Number Connection Test-B (NCT-B), Serial Dotting Test (SDT), Line Tracing Test (LTT) were expressed in seconds and those of the Digit Symbol Test (DST) in points. Results: A total of 102 healthy volunteers (54 men, 48 women) and 50 cirrhotic patients (29 men, 31 women) were included. The mean age was 38.1 ± 12.55 years in healthy volunteers and 49.3±15.6 years in cirrhotic patients. The mean years of education level was 11.63 ± 4.20 years in healthy volunteers and 9.62±3,9 years in cirrhotic patients. The PHES of the healthy volunteer group was -0.08 ± 1.28 and the cut-off between normal and pathological values was set at −3 points. PHES of the cirrhotic patients was -7.66 ± 5.62 points and significantly lower than that of volunteers (p <0.001). Prevalence of MHE was 74% among cirrhotic patients. Age and education level were associated with MHE.Conclusion: PHES cut-off value in Cameroonians is -3, with MHE prevalence of 74% among cirrhotic patients.

show abstract

Section: Discussioncontrasting

confidence: 51%

“…The cut-off between the normal and pathologic values of the PHES was set at -4 according to the lower boundary of the 95% range between + 2 and − 2 SD [1,7,9,[13][14]. In our study we considered the same methodology and we found that the lower limit was set at -3 points.…”

Section: Discussionmentioning

confidence: 99%

Normalization of the Psychometric Encephalopathy Score in Cameroonian Population

Djomatcho

Kowo

Ndam

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…The prevalence of CHE in Tunisia was higher in another study: 44%. 45 There are some limitations to the present study. Firstly, there is the lack cutoff values of StE based on a reference standard test and secondly, a relatively small sample size of patients was recruited in this study.…”

Section: Discussionmentioning

confidence: 86%

EncephalApp Stroop Test for covert hepatic encephalopathy screening in Tunisian cirrhotic patients

Hamzaoui,

Mahmoudi,

Mohamed

et al. 2023

F1000Res

View full text Add to dashboard Cite

Background: Covert hepatic encephalopathy (CHE) is underdiagnosed and is difficult to detect. The EncephalApp Stroop test is validated for its screening. The aim of the study was to define Tunisian norms for the test based on healthy controls norms and to estimate the prevalence of CHE in cirrhotic Tunisian patients. Methods: A prospective, multicenter, cross‐sectional study was conducted. Ambulatory or hospitalized cirrhotic patients aged 40 years and over were recruited at 11 centers. Healthy subjects aged 40 years and over were recruited at 8 centers. We used a translated Arabic version of the streamlined EncephalApp Stroop test. The task has two components: “Off” and “On” state depending on the discordance or concordance of the stimuli. Results: 142 patients were included. The mean age was 57.26 years [40–86]. 40 (28.17%) of cirrhotic patients who were included were diagnosed as having a minimal hepatic encephalopathy or CHE. Among the ineligible patients, 22 had overt hepatic encephalopathy. If we consider these patients, the overall prevalence rate of CHE was around 24.39% in cirrhotic patients. It was more frequent in women (34.21% vs 25.96%), and in patients whose level of school education is between 6 and 13 years. Its prevalence does not appear to be affected by gender, MELD score, etiology of cirrhosis and age group of patients, as these variables were independent with respective p according to the chi-square test 0.413; 0.736; 0.663 and 0.1. The stroop times (On / Off and On + Off) correlated significantly with each other, are associated significantly and positively with age (respective Pearson coefficients: 0.578; 0.567 and 0.6). The more the age increases, the more the stroop response times increases (p > 10-3). Conclusions: EncephalApp Stroop test was an efficient screening tool for CHE in Tunisian cirrhotic patients.

show abstract

Covert Hepatic Encephalopathy: How Aggressive Should We Be with Diagnosis and Management?

Allampati

Raheem

Mullen

2015

Curr Hepatology Rep

View full text Add to dashboard Cite

Encéphalopathie hépatique minime : un diagnostic précoce pour améliorer le pronostic

Cited by 6 publications

References 26 publications

Normalization of the Psychometric Encephalopathy Score in Cameroonian Population

Normalization of the Psychometric Encephalopathy Score in Cameroonian Population

EncephalApp Stroop Test for covert hepatic encephalopathy screening in Tunisian cirrhotic patients

Covert Hepatic Encephalopathy: How Aggressive Should We Be with Diagnosis and Management?

Contact Info

Product

Resources

About