2022
DOI: 10.3390/jof8050521
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Encephalartos villosus Lem. Displays a Strong In Vivo and In Vitro Antifungal Potential against Candida glabrata Clinical Isolates

Abstract: Recently, Candida glabrata has been recognized as one of the most common fungal species that is highly associated with invasive candidiasis. Its spread could be attributed to its increasing resistance to antifungal drugs. Thus, there is a high need for safer and more efficient therapeutic alternatives such as plant extracts. Here, we investigated the antifungal potential of Encephalartos villosus leaves methanol extract (EVME) against C. glabrata clinical isolates. Tentative phytochemical identification of 51 … Show more

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Cited by 11 publications
(7 citation statements)
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References 57 publications
(61 reference statements)
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“…Tissues of the paws were conserved in a formalin solution, retained in paraffin wax, spliced, and stained using hematoxylin and eosin (H&E) and Masson’s trichrome stain for staining of collagen fibers [ 49 ].…”
Section: Methodsmentioning
confidence: 99%
“…Tissues of the paws were conserved in a formalin solution, retained in paraffin wax, spliced, and stained using hematoxylin and eosin (H&E) and Masson’s trichrome stain for staining of collagen fibers [ 49 ].…”
Section: Methodsmentioning
confidence: 99%
“…Animals were randomly grouped into three groups, then all of them were administered bacterial suspension of E. faecalis (0.2 mL, 2.0 × 10 7 CFU/mL) for two days by subcutaneous (SC) injection to induce systemic infection. The three groups were as follows [ 24 , 32 ]:…”
Section: Methodsmentioning
confidence: 99%
“…Then, we examined TNF-α immunostaining using a light microscope, considering staining with TNF-α as a bad indication. The staining strength was classified into: absence of immunoreactive cells, (0) or negative; presence of 1–10% immunoreactive cells, (1) or weak; presence of 11–50% immunoreactive cells, (2) or moderate; and presence of more than 50% immunoreactive cells, (3) or strong [ 32 , 35 ].…”
Section: Methodsmentioning
confidence: 99%
“…The disc agar diffusion method for screening the antifungal potential of the green synthesized AgNPs was used as previously described [ 7 , 19 ]. In brief, sterile filter paper discs impregnated with AgNPs were added after spreading the fungal suspension on the SDA plates.…”
Section: Methodsmentioning
confidence: 99%