Encelin: A Fungal Growth Inhibitor

Abstract

A known sesquiterpene lactone, encelin, isolated from the Mexican species Montanoa speciosa (Compositae), was assayed for biocidal activity on fungal cells of Mucor rouxii. The results indicate that encelin has a determining action on growth and the morphogenetic process of fungal cells.

Mode of Antibacterial Action of Totarol, a Diterpene fromPodocarpus nagi

“…On the other hand, in spite of various numbers of antimicrobial phytochemicals, their action sites were rarely described. Like antibiotics, antimicrobial phytochemicals also have action medianisms including inhibition of RNA synthesis (5), respiration inhibition (6), cell membrane damage (7), and cell wall synthesis (8). Accumulation of this kind of knowledge may provide us with a more rational and scientific approach for drug design (9, 10).…”

Chemical Composition and Antioxidant DPPH Activity of the Floral and Leaves Essential Oils of cMontanoa speciosa</i> DC

“…While, Robles et al [13] performed the analysis of the chemical composition of leaves and flowers of Montanoa tomentosa by SPME-CG-EM and found in both cases that more than 65% of the compounds belong to the monoterpene series, being the compounds sabinene, α-pinene and α-thujene, the majority; In contrast to what was observed in this study. From Montanoa speciosa there are reports of biological activity and structural elucidation of sesquiterpene lactones obtained from the aerial parts of this plant [21], Sabanero et al [22], Quijano et al [23].…”

Chemistry and antifungal potential of Alantolides from Inula racemosa H

“…Structure of parent lactones (1 and 2) and their derivatives (3)(4)(5)(6)(7)(8) were identified on the basis of IR and 1 H NMR spectral data (table 1).…”

“…The diazomethane derivatives (3 and 4) were equally fungitoxic with ED 50 value comparable with compounds (1 and 2). The compounds (5)(6)(7)(8) showed fungitoxicity with the ED 50 value more than 300 μg/mL. The standard fungicide Indofil M45 was highly fungitoxic against Alternaria brassicae with the ED 50 value of 290 μg/mL.…”

“…Inula racemosa, commonly known as Pushkarmoola, is a plant of wide medicinal importance which belongs to family Asteraceae and has its origin in temperate and Alpine Western Himalayas. The plant contains eudesmanolide group of sesquiterpene lactones 3 namely, alantolactone (1) and isoalantolactone (2) as major components are known to exhibit wide variety of biological activities which include antispasmodic, 3 hypoglycaemic activity, 4 antifungal [5][6][7][8][9][10][11] and antimalarial. 12 Sesquiterpene lactones on reaction with diazomethane afforded crystalline pyrazoline derivative besides other products.…”