Encefalopatía hiperamonémica asociada a ácido valproico por posible sinergismo con fenobarbital y topiramato: comunicación de tres casos

Cano-Zuleta, A.; Hernández-Ortíz, O.H.; González-González, César Alfredo; Amariles, Pedro

doi:10.1016/j.farma.2011.09.005

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…Although the use of TPM can be associated with cognitive symptoms, this side effect appears to be due to a direct effect of the drug in the CNS and is not secondary to any metabolic abnormality. Hyperammonemia secondary to the combined use of TPM and other antiepileptic drugs, particularly VPA, has been reported but is probably not common, with only a few cases reported in the literature [1–8] .…”

Section: Discussionmentioning

confidence: 99%

“…As a group, antiepileptic drugs are a relatively common cause of encephalopathy, either by direct CNS effect, or, in some cases, by inducing hyperammonemia. This is a well-established complication of valproic acid and has now been reported to occur in patients previously treated with valproic acid to which TPM was added [1–8] . Topiramate is a broad-spectrum anticonvulsant that is also extensively used for migraine prophylaxis, as a mood stabilizer, and for alcohol dependency.…”

Section: Introductionmentioning

confidence: 93%

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Topiramate-induced hyperammonemic encephalopathy in a patient with mental retardation: A case report and review of the literature

Tantikittichaikul

Johnson

Laengvejkal

et al. 2015

Epilepsy & Behavior Case Reports

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Hyperammonemia is an uncommon side effect of topiramate (TPM) that has only been reported when it is used as an adjunct to valproate. We report a patient with mental retardation who developed reversible encephalopathy from TPM. Ammonia level was monitored during the course of TPM treatment. This patient had recurring, reversible elevations in serum ammonia levels that coincided with the administration of TPM. To our knowledge, symptomatic hyperammonemia has not been reported to occur with TPM monotherapy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 93%

Topiramate-induced hyperammonemic encephalopathy in a patient with mental retardation: A case report and review of the literature

Tantikittichaikul

Johnson

Laengvejkal

et al. 2015

Epilepsy & Behavior Case Reports

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Encefalopatía hiperamonémica por ácido valproico, sin elevación de transaminasas: Reporte de Caso

Escobar-Toledo

Mejía

2021

Rev. Fac. Cienc. Salud Univ. Cauca

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Las encefalopatías tóxicas pueden ser causadas por una gran variedad de xenobióticos por mecanismos directos e indirectos simulando enfermedades metabólicas autoinmunes o neoplásicas. Por ende, requieren un anamnesis adecuada, un examen físico amplio y en cuanto a lo toxicológico tratar siempre de encontrar un nexo epidemiológico. Dentro de las principales causas están psicofármacos y drogas de abuso. El reconocimiento temprano de una encefalopatía tóxica es fundamental entendiendo que llevará al retiro de la noxa, inicio de manejo disminuyendo complicaciones y mortalidad asociada. Se describe el caso de una paciente co ingesta de ácido valproico quien presentó una encefalopatía por este anticonvulsivante sin compromiso de enzimas hepáticas, con alteraciones en el electroencefalograma que revirtieron por completo con la suspensión del medicamento. La importancia de este caso está en reconocer al ácido valproico como una causa de encefalopatía.

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Interactions with Drugs and Dietary Supplements Used For Weight Loss

Jordan¹

2013

Drug Discovery

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Encefalopatía hiperamonémica asociada a ácido valproico por posible sinergismo con fenobarbital y topiramato: comunicación de tres casos

Cited by 3 publications

References 6 publications

Topiramate-induced hyperammonemic encephalopathy in a patient with mental retardation: A case report and review of the literature

Topiramate-induced hyperammonemic encephalopathy in a patient with mental retardation: A case report and review of the literature

Encefalopatía hiperamonémica por ácido valproico, sin elevación de transaminasas: Reporte de Caso

Interactions with Drugs and Dietary Supplements Used For Weight Loss

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